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Diet Induced Hypomethylation in Preneoplastic Liver
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Research Initiative
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FDA
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NCI
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The Food and Drug Administration (FDA)'s the National Center for Toxicological Research, and the National Cancer Institute (NCI)'s Division of Cancer Prevention, Nutritional Sciences Research Group are collaborating on an Interagency Agreement in which NCI will provide funds to examine the role of epigenetic mechanisms as factors that determine susceptibility to the development of hepatocellular carcinoma and to examine epigenetic alterations which may be used as markers of susceptibility to disease development, and whether correction of those epigenetic abnormalities during hepatocarcinogenesis may be a crucial decisive factor in cancer prevention strategies.2022 publication update - Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet.Tryndyak VP, Willett RA, Avigan MI, Sanyal AJ, Beland FA, Rusyn I, Pogribny IP.Epigenetics. 2022 Nov;17(11):1462-1476. doi: 10.1080/15592294.2022.2043590. Epub 2022 Mar 24.PMID: 35324388
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Dietary Biomarker Development Consortium
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Resource Development
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Not Reported
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NIDDK
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NIDDK collaborates with USDA-NIFA to convene a consortium for the development of Dietary Biomarkers of intake. The consortium has three grantees namely Harvard, Fred Hutch Cancer Center and UC-Davis for the development of dietary biomarkers and a coodinating center at Duke.
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Dietary Guidelines for Americans and Sustainability Task Force
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Committee, Work group, Advisory group, or Task Force
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Not Reported
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NCI
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The Workgroup will examine a process framework for considering incorporating sustainability in the Dietary Guidelines for Americans (Dietary Guidelines) process as well as other federal nutrition policies and programs as appropriate.
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Dietary Supplement Research Coordinating Committee
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Committee, Work group, Advisory group, or Task Force
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CDC, FDA
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NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NINR, NLM, OD/DPCPSI/OBSSR, OD/DPCPSI/ODS, OD/DPCPSI/ONR, OD/DPCPSI/ORWH
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The National Institutes of Health's, Office of Dietary Supplement Dietary Supplement Research Coordinating Committee (DSRCC) was established in 2022 by the Office of Dietary Supplements (ODS) to increase collaboration among NIH Institutes, Centers, and Offices and federal agency partners whose programs include work that focuses on dietary supplements and the intersection of dietary supplement, natural product, and nutrition research. The DSRCC provides research coordination through the exchange of programmatic and scientific information, collaborative planning, and the implementation of relevant activities and initiatives.
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Dietary Supplement Special Interest Databases
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Resource Development
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CDC, FDA
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NCI, OD/DPCPSI/ODS
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NIH ODS leads the development of publicly accessible database resources to expand knowledge of the composition of dietary supplements and to support research on dietary supplement use by different populations across the lifespan and investigations of their health effects. The Dietary Supplement Ingredient Database (DSID) and the Dietary Supplement Label Database (DSLD) contain information on the composition of many dietary supplements sold in the United States and, together with food composition databases, enable more accurate estimates the total daily intakes of nutrients and other bioactive substances from dietary intake. Databases of dietary supplement and food composition for certain specific nutrients, such as iodine, purines, and nitrates/nitrites, provide tools for epidemiologic research characterizing the nutrient status of diverse populations.
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Digestive Diseases Interagency Coordinating Committee (DDICC)
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Committee, Work group, Advisory group, or Task Force
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CDC, CMS, FDA
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NCI, NIBIB, NIDDK
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The Digestive Diseases Interagency Coordinating Committee, chaired by NIDDK, is charged with facilitating cooperation and collaboration in research efforts in digestive diseases among NIH Institutes and other relevant Federal health agencies to provide a structure for coordinated efforts to combat digestive diseases. The Committee also prepares reports on the status of digestive disease research funding as well as needs for future research in specific areas of digestive diseases. The Committee meets to encourage exchange of information among member organizations and develop common initiatives.
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Digital Health R&D (DHRD) Interagency Working Group
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Committee, Work group, Advisory group, or Task Force
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AHRQ, FDA, ONC
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NCATS, NCI, NHLBI, NIA, NIBIB, NICHD, NIMH, OD/DPCPSI/OBSSR, OD/OSP
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The Digital Health R&D (DHRD) Interagency Working Group was formed in 2010 as the Health Information Technology R&D IWG to coordinate Federal R&D for improving medical, functional, and public health outcomes across 15 participating agencies. Guided by the four fundamental challenges described in the Federal Health Information Technology Research & Development Strategic Framework, the IWG advances R&D by coordinating agency plans and activities, promoting collaborations, and providing a forum for exchanging information and articulating R&D needs to policy-makers and decision-makers.Digital health, as defined by the FDA, includes a wide range of R&D areas, such as mobile health (mHealth), wearable devices, telehealth, and personalized medicine, as well as computing platforms, connectivity, software, sensors to collect data, and AI/ML to analyze health-related data.Strategic PrioritiesAccelerate the R&D and implementation of next-generation health IT tools and services to reduce administrative burden, enable a new bio economy, and serve the full community of users.Leverage the power of data, computing, and AI to promote infrastructure and standards for accessible, interoperable, reusable health data, devices, and related applications.Develop privacy-preserving and secure methods, standards, testing, certification, and data transfer strategies to make systems and repositories more robust and accessible for research collaboration.Provide education and training opportunities to build the diverse, highly skilled, and interdisciplinary health IT workforce of the future.
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Digital.gov Multilingual Community of Practice
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Committee, Work group, Advisory group, or Task Force
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Not Reported
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NIA
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The Multilingual Community of Practice works together to solve common issues, to offer translation best practices, to define terminology, and to be a resource to each other.
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Disability Data Interagency Working Group
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Committee, Work group, Advisory group, or Task Force
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Not Reported
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NIA
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The purpose of the DDIWG is to coordinate activities to strengthen the federal government’s use of disability data to advance equity for people with disabilities. Within the broader scope of equitable data, this work will allow for rigorous assessment of the extent to which government programs and policies yield consistently fair, just, and impartial treatment of people with disabilities.
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Disaster Research Response Network (DR2)
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Committee, Work group, Advisory group, or Task Force
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CDC
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FIC, NCI, NIA, NIEHS, NINDS
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The DR2 Program provides training, funding, and a Resources Portal of tools to empower human health research in response to disasters and public health emergencies.
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