Report on NIH Collaborations with Other HHS Agencies

This annual report describes the extent and nature of activities undertaken by the National Institutes of Health (NIH) in collaboration with other agencies and divisions of the Department of Health and Human Services (HHS).  For an organization as complex as HHS, which has 11 operating divisions, many additional staff divisions, and more than 300 programs, synergy between the different components of the Department is vital to the success of the whole.  Recognizing this, Congress added section 403A(a) of the Public Health Service Act, 42 U.S.C. § 283a(a), Annual Reporting to Increase Interagency Collaboration and Coordination, via Section 104 of the National Institutes of Health Reform Act of 2006.  This law mandates that the NIH Director provide to the Secretary of HHS an annual report on NIH’s collaborations with other HHS Agencies.

The collaborative activities detailed in this report illustrate how NIH works across the Department to cultivate partnerships, leveraging the respective strengths of all HHS agencies to support the HHS mission and strengthen the public health ecosystem.  Cooperation and collaboration is critical to realizing the HHS goal of protecting the health of all Americans and providing essential human services, especially for those who are least able to help themselves.

Current and past reports can be found on the NIH Research Portfolio Online Reporting Tools (RePORT) website located at This website also includes a searchable comprehensive table of all reported activities.

In 2015, OSP conducted a formal evaluation of NIH-HHS collaborations, using data from this Report on NIH Collaborations with Other HHS Agencies as well as survey and interview responses of HHS staff.


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NIH-Wide Research Collaborations

Today, more than ever, the National Institutes of Health's (NIH) Institutes, Centers, and Offices (ICOs) are working together in new ways and leveraging their unique strengths and resources. NIH-wide collaborations can be found in all disease areas and across basic, translational, and clinical research. These activities represent unique opportunities to build on the scientific expertise, sophisticated technologies, infrastructure, and knowledge base of individual ICOs and to apply this wealth of information to addressing a wide range of diseases and health conditions. NIH-wide collaborations provide multi-disciplinary and multi-faceted approaches to critical scientific questions and lead to special initiatives and innovative programs for the discovery, development, and testing of strategies to diagnose, prevent, and treat a wide range of health conditions. Moreover, they enable NIH to leverage crucial resources to ensure precious research dollars are used effectively and efficiently in improving the public health of all Americans.

In accordance with the Public Health Service Act, as amended by the 21st Century Cures Act, the FY 2019-2021 report summarizes the amounts of funding NIH applied toward inter-institute/center research collaborations in those fiscal years. Please click here to view previous reports.  

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