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Genome in a Bottle Consortium
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Resource Development
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CDC, FDA
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NCI, NHGRI, NLM
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The Genome in a Bottle (GIAB) Consortium, hosted by the National Institute of Standards and Technology, is a public-private-academic consortium to develop the technical infrastructure (reference standards, reference methods, and reference data) to enable translation of whole human genome sequencing to clinical practice and innovations in technologies. The priority of GIAB is authoritative characterization of human genomes for use in benchmarking, including analytical validation and technology development, optimization, and demonstration. NLM/NCBI provides data portal (Data Coordination Center) and data management and contributes data analysis to GIAB. https://www.nist.gov/programs-projects/genome-bottle ; https://ftp.ncbi.nlm.nih.gov/ReferenceSamples/giab/
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Genome: Unlocking Life's Code
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Public Education Campaign
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Not Reported
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NHGRI
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The “Genome: Unlocking Life’s Code” public education campaign is a partnership between the National Museum of Natural History (NMNH) and the National Human Genome Research Institute (NHGRI). The partnership initiated in 2013 with the collaborative development of the exhibition, which was hosted initially at NMNH and then traveled across the US and internationally for a decade. Now the Unlocking Life’s Code website is maintained as an educational resource hub for K-12 and informal education teachers, students, and the general public.”
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Genomic epidemiology of norovirus GII.4 globally
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Research Initiative
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FDA
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FIC
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Collaboration with Dr. Gabriel Parra's team at FDA. His group has compiled a global genomic dataset of thousands of norovirus GII.4 genomic sequences spanning 37 years of sampling. Dr. Nidia Trovao's team at the NIH/FIC will employ molecular epidemiology concepts and phylodynamic modeling to shed light on the viral evolutionary history and transmission dynamics. We will also gain insight into the viral diversity circulating across countries/regions, how the viral effective population size changes over time, and identify source-to-sink patterns in norovirus GII.4 spread. This will be important to inform control strategies and the development of therapeutics and vaccines.
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Global Change Research Program
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Committee, Work group, Advisory group, or Task Force
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CDC
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FIC, OD/DPCPSI/ONR
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The U.S. Global Change Research Program (USGCRP) was established by Congress in 1990 to coordinate federal research and investments in understanding the forces shaping the global environment, both human and natural, and their impacts on society. USGCRP facilitates collaboration and cooperation across 15 federal member agencies to advance understanding of the changing Earth system. Research supported by USGCRP informs the Nation in navigating the challenges of a changing environment and identifying opportunities for a more resilient future. Together, USGCRP and its member agencies provide a gateway to authoritative science, tools, and resources to help people and organizations across the country manage risks and respond to changing environmental conditions.
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Global Initiative for Cancer Registry Development
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Committee, Work group, Advisory group, or Task Force
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CDC
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NCI
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Cancer incidence and mortality are rising rapidly worldwide, particularly in low- and middle-income countries. There is overwhelming need for countries to adopt and implement cancer control actions, yet only one in five low- and middle-income countries have the necessary data to inform policy and research in order to reduce the cancer burden. Such data are necessary to measure progress toward achieving targets set for the World Health Organization cancer initiatives. The Global Initiative for Cancer Registry Development (GICR) is a coordinated, multi-partner approach to deliver the required change. Its objective is to make cancer data count, particularly in lower resource settings, through providing training and technical support to countries in population-based cancer registration and research.
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GlycoBiology Scientific Interest Group
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Committee, Work group, Advisory group, or Task Force
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FDA
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NCI, NHGRI, NHLBI, NIAID, NICHD, NIDCR, NIDDK, NIGMS
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A core group of laboratories representing several institutes and the FDA, form the postdoctoral training laboratories of the Glycobiology SIG. Laboratory training is augmented with a “Special Topics in Glycobiology Course,” a seminar series and an annual NIH FDA Glycosciences Research Day held each spring that highlights work being done locally in the glycosciences. A Steering Committee composed of both intra and extramural NIH, FDA, NIST and DOE scientists organize the SIGs activities.
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GM/CA@APS External Advisory Board
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Committee, Work group, Advisory group, or Task Force
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Not Reported
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NCI, NIGMS
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The National Institute of General Medical Sciences and National Cancer Institute Structural Biology Facility at the Advanced Photon Source operates a national user facility for structural biology with synchrotron beamlines specializing in intense, tunable micro-beams for crystallography.
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Government-University-Industry Research Roundtable
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Committee, Work group, Advisory group, or Task Force
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FDA
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NCATS, OD/IMOD
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The National Academies of Sciences, Engineering, and Medicine Government-University-Industry Research Roundtable is charged with improving the research enterprise of the United States by successfully resolving the cross-sectoral issues that prevent the U.S. research enterprise from reaching its full potential. This mission is achieved by convening senior-most representatives from government, universities, and industry to frame the critical issues, followed – when appropriate – by the execution of activities designed to address specific cross-sectoral impediments to achieving a healthy, vibrant research enterprise. GUIRR provides a unique forum for dialogue among top government, university and industry leaders of the national science and technology enterprise.
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GSRS
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Research Initiative
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Not Reported
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NCATS, OD/OIR
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GSRS is a public software and web application that supports the registration and documentation of substances found in medicinal products. Importantly, the definition of substances is based on a global and consistent definition (ISO 11238 standard). The software has been heavily utilized at the FDA since 2016, and has also been adopted by other regulatory agencies around the world, such as EMA (European Medicines Agency), BfArM (Federal Institute for Drugs and Medical Devices) and WHO-UMC. NCATS provides access to a public instance of the software, and to the latest publicly available data on substance definitions and properties, as provided by the FDA, for use by the broader translational research community.
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H-CORE Immune Assay CoP Team
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Committee, Work group, Advisory group, or Task Force
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ASPR, BARDA
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NIAID
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A continuation of the OWS SARS-CoV-2 Immune Assays Subteam_Assay Working Group but with a more narrow focus on immune correlates of protection.
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