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The Adolescent Brain Cognitive Development Study (ABCD Study) (ABCD)
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Research Initiative
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CDC
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OD/DPCPSI/ORWH, NCI
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The ABCD (Adolescent Brain Cognitive Development) Study is the largest longitudinal research study of brain development and child health in the United States. Investigators at a consortium of 21 data collection sites across the United States will measure brain maturation in the context of social, emotional, and cognitve development, as well as a variety of health and environmental outcomes. The study aims to collect data on the behavior and brain development of over 11,500 children beginning at age 9-10 and continuing through young adulthood.
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The APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Steering Committee Meetings
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Committee, Work group, Advisory group, or Task Force
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HRSA
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NIAID, NIDDK, NIMH
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The APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) aims to prospectively assess the effects of renal-risk variants (RRVs) in the apolipoprotein L1 gene (APOL1) on outcomes for kidneys from donors with recent African ancestry and the recipients of their kidneys, after deceased- and living-donor renal transplantation. For the purposes of APOLLO, recent African ancestry is defined as individuals with similar genetic make-up to those currently residing in Africa. APOLLO will also study the impact of APOL1 RRVs on the health of living kidney donors with recent African ancestry.
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The Assay Guidance Manual (AGM)
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Resource Development
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FDA
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NCATS
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The Assay Guidance Manual (AGM) is a free, best-practices online resource devoted to the successful development of robust, early-stage drug discovery assays.
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The Assistant Secretary for Preparedness and Response (ASPR)& chemical, biological, radiological and nuclear defense team
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Committee, Work group, Advisory group, or Task Force
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OS, ASPR
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NCI, NIAID
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The National Cancer Institute (NCI) and the National Institute of Allergy and Infectious Diseases (NIAID) participate in Assistant Secretary for Preparedness and Response (ASPR)'s chemical, biological, radiological and nuclear defense team. Both NCI and NIAID provide expertise on radiation topics and for the Biomedical Advanced Research and Development Authority (BARDA), within the Office of ASPR in the U.S.
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The Effect of Various Drugs on the Retina
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Research Initiative
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FDA
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NEI
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Using powerful in vivo imaging technology, it is possible to view the retina at the cellular level. This collaboration with the Food and Drug Administration (FDA) seeks to monitor changes to the retina for drugs that are known to cross the blood/retina barrier to better understand possible toxicity.
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The Environmental Determinants of Diabetes in the Young (TEDDY)
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Research Initiative
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CDC
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NIDDK, NIAID, NICHD, NIEHS
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This consortium is organizing international efforts to identify infectious agents, dietary factors, or other environmental factors that trigger type 1 diabetes in genetically susceptible people. The study enrolled over 8,000 newborns and is following them for 15 years to identify environmental triggers of type 1 diabetes.
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The Epidemiology of Burkitt Lymphoma in East-African Children and Minors (EMBLEM)
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Research Initiative
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CDC, FDA
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NCI, NHGRI, NHLBI
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The Epidemiology of Burkitt Lymphoma in East-African Children and Minors (EMBLEM) initiative provides a unique infrastructure to obtain valuable data and samples to study Burkitt’s lymphoma (BL) epidemiology. Study data will help characterize or investigate: (1) The association of malaria-resistance genes with endemic BL. (2) Host genetic polymorphisms associated with BL using genome-wide association methods. (3) The role of the Epstein-Barr virus (EBV) genetic variants in endemic BL. (4) The role of malaria immunology and phenotype of inflammation in BL. (5) The complexity of coinfection with different P. falciparum malaria genotypes in BL. (6) The interaction between helminthic parasites, HIV, malaria, and EBV in BL. (7) The immunohistochemistry and molecular pathology of BL. (8) The impact of malaria, helminthic parasites, and HIV on childhood BL.
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The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)
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Research Initiative
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CDC
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NIDDK
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GRADE is a randomized clinical trial of participants diagnosed with type 2 diabetes within the past 10 years who are already on metformin. Participants will be randomly assigned to 1 of 4 commonly-used glucose-lowering drugs (glimepiride, sitagliptin, liraglutide, and basal insulin glargine), plus metformin, and will be followed for up to 7 years. The goal of the GRADE Study is to determine which combination of two diabetes medications is best for achieving good glycemic control, has the fewest side effects, and is the most beneficial for overall health in long-term treatment for people with type 2 diabetes.
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The Golestan Cohort Study of Esophageal Cancer
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Research Initiative
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CDC
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NCI
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The National Cancer Institute (NCI) and the Centers for Disease Control and Prevention (CDC) are collaborating on a pilot study to measure nitrate in urine. The aim of the pilot is to determine if drinking water sources in high and low nitrate regions of Golestan province are associated with higher urinary nitrate concentrations (a biomarker of ingestion) after accounting for dietary intake.
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The Impact of Tobacco Use on Oral Health and the Oral Microbiome
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Research Initiative
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CDC, FDA
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NCI
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The US Food and Drug Administration Intramural Center of Tobacco Regulatory Science Award Program funded a project examining how tobacco affects oral health and the oral microbiome in the National Health and Nutrition Examination Survey (NHANES) study.
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