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SARS-CoV-2 Sequencing for Public Health Emergency Response, Epidemiology and Surveillance (SPHERES)
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Other
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CDC, FDA
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NLM, NIAID
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To help accelerate the use of near-realtime pathogen genomic data throughout the pandemic response, CDC’s Advanced Molecular Detection (AMD) program (https://www.cdc.gov/amd) is establishing an open genomics consortium to spearhead and organize public health sequencing and response efforts across the United States. This consortium, SARS-CoV-2 Sequencing for Public Health Emergency Response, Epidemiology and Surveillance (SPHERES), is intended to help coordinate and support sequencing at state and local public health laboratories across the country, and to better engage clinical, academic and commercial laboratories that are sequencing – or planning to sequence -- SARS-CoV-2 at any scale. With this coalition, we hope to improve communication and knowledge-sharing between US laboratories, to develop consensus guidance on data and metadata standards, to reduce barriers to bioinformatic analysis and data sharing, and to better align sequencing requirements and resource needs with different sources of funding, technology, expertise and other means of support.
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SEARCH for Diabetes in Youth (SEARCH)
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Research Initiative
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CDC
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NIDDK
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SEARCH is a multi-center study designed to characterize the epidemiology of both type 1 diabetes and type 2 diabetes in the population aged <20 years, along with the associated complications, quality of diabetes care, and quality of life of children and youth with diabetes. SEARCH aims also include 1) the development and validation of simple and low-cost case definitions and classifications of diabetes types in youth, 2) the establishment of a repository of biological specimens, and 3) systems to maintain contact with study participants to facilitate studies of childhood diabetes.
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Secretary's Advisory Committee on Infant Mortality
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Committee, Work group, Advisory group, or Task Force
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CDC, HRSA
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NICHD
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The Secretary’s Advisory Committee on Infant Mortality (SACIM) was formed in 1991 to advise the Secretary on Department of Health and Human Services’ programs that are directed at reducing infant mortality and improving the health status of pregnant women and infants.
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Senior Medical Advisor to Assistant Secretary for Preparedness and Response (ASPR)
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Committee, Work group, Advisory group, or Task Force
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OS, IOS
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NCI
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A National Cancer Institute (NCI) staff member serves as Senior Medical Advisor to the Office of the Assistant Secretary for Preparedness and Response (ASPR). As such, NCI helps to develop plans for emergency and disaster responses and plays a role in responses operations as needed. A good number of the Operations plans and models that apply to all hazards have been developed from NCI science and knowledge.
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Sepsis Interagency Meeting
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Meeting/ Workshop
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AHRQ, CDC, CMS
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NIGMS, CC, NHLBI, NIAID, NICHD
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Discuss Sepsis Priority Areas identified in Biomedical Advanced Research and Development (BARDA) market research: ;Unifying definitions of Sepsis across the patient continuum, Harmonizing Data for Access and Interoperability, Optimizing Health Outcomes and Reducing Economic Burden, Improving Evaluation and Catalyzing Adoption of Critical Technologies.
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Sequencing Quality Control Phase 2 (SEQC2)
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Resource Development
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FDA
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NLM, CIT, NCI, NHLBI, NIEHS
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The Sequencing Quality Control (SEQC) consortium is an FDA-led community-wide effort. SEQC2 is a project within the consortium. SEQC2 goals: (1) to develop quality metrics for reproducible NGS results from both whole genome sequencing (WGS) and targeted gene sequencing (TGS), (2) to benchmark bioinformatics methods for WGS and TGS towards the development of standard data analysis protocols, and (3) to assess the joint effects of key parameters affecting NGS results and interpretation for clinical application. NLM/NCBI provides an NCBI data portal for and contributes data analysis to this effort.
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Sex Differences Meeting Planning Committee
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Meeting/ Workshop
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BARDA
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NIAID, OD/DPCPSI/ORWH
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Understanding sex differences within animal models is needed to develop effective biodosimeters and MCMs. Therefore, a meeting is planned to 1) explore sex differences in metabolomics and/or other biomarkers that may track with assessing acute radiation syndrome (ARS), delayed effects of acute radiation exposure (DEARE), and/or predicting the efficacy of MCMs; 2) look at effects of synchronizing estrocycle in pre-clinical studies, and pheromones when co-housing male and female animals; 3) explore regulatory challenges in clinical studies involving representation from both sexes and policies that influence inclusion of women in research, and the gaps that exist in these practices. Meeting to be held Oct 25-26, 2021.
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Sexual Assault Awareness and Prevention Month
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Public Education Campaign
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CDC
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OD/DPCPSI/ORWH
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ORWH developed a blog for its website for this national observance.
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SHIELD Standardization of Lab Data to Enhance Outcomes Research and Value Based Care (SHIELD)
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Committee, Work group, Advisory group, or Task Force
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FDA
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NLM
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This project will expand the collaborative efforts of FDA and other stakeholders involved in the SHIELD initiative to ensure laboratory information interoperability, such that the same type of device is described the same way in electronic health records (EHR) systems. To realize this goal, this project will develop code mapping manuals to consistently map the same LOINC (Logical Observations Identifiers Names and Codes) to the same type of IVD. This is important because without the specific guidance, manufacturers of IVD devices and laboratories often assign different (and frequently incorrect) LOINC codes for the same type of device. This project will also pilot implementation of SHIELD standard digital formats to update infrastructure in active healthcare provider laboratories, which will include the seamless distribution of LOINC and SNOMED-CT (Systematized Nomenclature of Medicine--Clinical Terms) coding to those provider institutions and registries.
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Smokefree.gov
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Resource Development
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CDC, FDA, IHS
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NCI, NIMHD
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The Smokefree.gov Initiative (SFGI) provides smokers who want to quit with free, evidence-based smoking cessation information and on-demand support. SFGI includes 6 mobile-optimized websites, 9 SMS text programs, 2 smartphone apps, and 6 social media platforms, available in English and Spanish. Tailored content is provided for special populations including women, teens, veterans, and people older than age 60.
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