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Gabriella Miller Kids First Common Fund Working Group
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Committee, Work group, Advisory group, or Task Force
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CDC
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NICHD, NCI, NEI, NHGRI, NHLBI, NIAAA, NIAMS, NIDA, NIDCR, NIDDK, NIEHS, NINDS, OD/DPCPSI/ORIP
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The National Institutes of Health (NIH) Gabriella Miller Kids First Common Fund Working Group supports the goals and initiatives of the NIH Gabriella Miller Kids First Common Fund Pediatric Research Program (Kids First). Kids First is developing a data resource for the pediatric research community of well-curated clinical and genetic sequence data that will allow scientists to identify genetic pathways that underlie specific pediatric conditions but that may also be shared between apparently disparate conditions. A representative from the Centers for Disease Control and Prevention (CDC) participates in the Kids First Working Group.
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Genetic Studies in the National Birth Defects Prevention Study
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Research Initiative
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CDC
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NHGRI
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This study is a collaboration between The Centers for Disease Control and Prevention (CDC) and the National Human Genome Research Institute (NHGRI) to carry out DNA sequencing and genotyping on samples collected as part of the National Birth Defects Prevention Study.
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Genomic Surveillance at US Swine Fairs
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Resource Development
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CDC
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FIC, NIAID
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The goal of this project is to identify zoonotic influenza A viruses (IAV) that are capable of transmitting from swine to humans, causing illness and potentially igniting a global pandemic. IAVs are collected from pigs attending US agricultural fairs and genome sequenced, either in real-time using nanopore sequencing technology or later at a CEIRS network lab. Viruses collected from humans that appear to be of swine origin are also sequenced and compared to the swine viruses. Phylogenetic analysis is performed to understand how viruses from agricultural fairs in different US states are genetically related and how the virus moves between events. Serological studies are performed in youth exhibitors attending the fair to determine exposure histories.
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GeT-RM Browser
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Resource Development
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CDC
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NLM
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The GeT-RM Coordination Program is a Centers for Disease Control and Prevention (CDC) project for establishing a community process to create reference materials, quality control measures, and proficiency testing for genetic testing. The GeT-RM Browser is provided by National Center for Biotechnology Information (NCBI) to facilitate access to the data generated by this project, which is intended to aid evaluation of the analytical validity of next-generation sequencing assays.
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Global Environmental and Occupational Health (GEOHealth)
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Research Initiative
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CDC
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FIC, NCI, NIEHS
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Fogarty International Center (FIC), National Cancer Institute (NCI), National Institute of Environmental Health Sciences (NIEHS), Centers for Disease Control and Prevention''s (CDC) National Institute for Occupational Safety and Health (NIOSH), Canada’s International Development Research Centre (IDRC), and the Global Alliance for Clean Cookstoves are supporting Global Environmental and Occupational Health (GEOHealth) Hubs. These are regional hubs based at low- or middle-income country (LMIC) institutions focused on collaborative research, data management, training, curriculum development, and policy support around high-priority local, national, and regional environmental and occupational health threats. The expectation is that GEOHealth Hubs will become the lead resources for environmental and occupational health, attract and retain the best talent in the region, and provide the scientific evidence for policy formulation. Together all regional hubs supported will form the GEOHealth Network, a platform for coordinated environmental and occupational health research and research training activities. FIC and its partners are supporting linked U2R and U01 awards to US and LMIC institutions, respectively. In FY19, CDC/NIOSH contributed in kind time and expertise to the program.
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Global Health - Household Air Pollution Investigation Network (HAPIN)
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Research Initiative
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CDC
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OD/DPCPSI/OSC, FIC, NCI, NHLBI, NICHD, NIEHS
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The Household Air Pollution Investigation Network (HAPIN) is a large National Institutes of Health (NIH) initiative designed to tackle the challenge of reducing the burden of disease from household air pollution (HAP). Within HAPIN, an Implementation Science Network (ISN) was formed to advance the science of uptake and scale-up of clean cooking technology in the developing world. The ISN steering committee is composed of HAP experts from across NIH and various government and non-government agencies.
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Global Health Security Agenda (GHSA) Action Package Prevent 3 (APP3), Biosafety and Biosecurity Working Group
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Committee, Work group, Advisory group, or Task Force
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CDC, OS
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OD/OSP
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Promotes awareness and implementation of comprehensive national-level biosafety and biosecurity frameworks within the Global Health Security Agenda.
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Global Ingredient Archival System (GINAS)
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Research Initiative
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FDA
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NCATS
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The Global Ingredient Archival System is a project that aims to provide a common identifier for all of the substances used in medicinal products, utilizing a consistent definition of substances globally, including active substances under clinical investigation, consistent with the ISO 11238 standard. The Food and Drug Administration (FDA) is utilizing software from this project to meet their obligations under the Identification of Medicinal Products (IDMP) global regulatory scheme. In 2016, the software was deployed onto FDA internal systems and FDA’s existing data was migrated into their instance (internally called Global Substance Registration Service (GSRS)). A public version of FDA’s substance definitions for use by researchers outside the agency was made available through the National Center for Advancing Translational Sciences(NCAT) website for the project.
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Global Initiative for Cancer Registry Development
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Other
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CDC
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NCI
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Cancer incidence and mortality are rising rapidly worldwide, particularly in low- and middle-income countries. There is an overwhelming need for countries to adopt and implement cancer control actions. Yet only one in five low- and middle-income countries have the necessary data to drive policy and reduce the burden and suffering due to cancer. The Global Initiative for Cancer Registry Development (GICR) is a coordinated, multi-partner approach to deliver the required change. Its objective is to make cancer data count.
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Global Strategic Plan to Prevent Harms Associated with Alcohol Misuse
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Meeting/ Workshop
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CDC, SAMHSA
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NIAAA
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The National Institute on Alcohol Abuse and Alcoholism (NIAAA) represented the Department of Health and Human Services (HHS) at the World Health Organization, coordinating with officials at the Centers for Disease Control and Prevention (CDC) and the Substance Abuse and Mental Health Services Administration (SAMHSA) to review Global Strategies to Prevent Harms Associated with Alcohol Misuse.
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