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Characterize Emerging HIV Strains from Blood Donors and Patients
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Resource Development
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FDA
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NIAID
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This initiative will characterize emerging HIV strains from blood donors and patients to determine viral tropism based on co-receptor usage strains. It will update the global viral panels to analyze multiple, diverse isolates from different parts of the world. This activity is part of the National Institute of Allergy and Infectious Diseases (NIAID) ongoing efforts to develop a well-characterized repository for diagnostics, and drug and vaccine studies.
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CHEMM (Chemical Hazards Emergency Medical Management)
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Resource Development
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ATSDR, CDC, OS
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NLM, NICHD
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This activity is to develop and maintain a comprehensive web resource and mobile app (in conjunction with the Wireless Information System for Emergency Responders [WISER]). Chemical Hazards Emergency Medical Management (CHEMM) is a tool designed to provide access to comprehensive sets of information about chemical hazards and emergency medical management via a user-friendly interface.
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Children’s HHS Interagency Leadership on Disasters (CHILD) Working Group
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Committee, Work group, Advisory group, or Task Force
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ACF, CDC, HRSA, OS, SAMHSA
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NICHD, NIDA, NINDS
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The Office of the Assistant Secretary for Preparedness and Response (ASPR) and the Administration for Children and Families (ACF) created the CHILD Working Group in February 2010 to integrate the needs of children across all HHS disaster planning activities and operations. The CHILD Working Group assessed current capabilities and facilitated coordination at the policy and response levels. The CHILD Working Group also developed a set of recommendations that could enhance how the Department provides and facilitates care to address the disaster-related health and human services needs of children (birth through age 17) during and after disasters or public health emergencies. The 2011 Update on Children and Disasters (2011 Summary) reported on the following areas: (1) mental and behavioral health; (2) medical countermeasures; (3) child physical health, emergency medical services, and pediatric transport; and (4) child care and child welfare. The 2012-2013 CHILD Report provided updates on those topics and added three additional areas of focus: (1) pregnant and breastfeeding women and newborns; (2) children with special health care needs and other subpopulations of children at heightened risk and historically under-represented in disaster planning efforts; and (3) enhancing collaboration across government and with non-governmental organizations (NGO).
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Chinese Children and Families Cohort Study
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Research Initiative
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CDC
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NCI, OD/DPCPSI/ODS
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The Chinese Children and Families Cohort Study (CFCS) was funded by and conducted in collaboration with the US Centers for Disease Control and Prevention (CDC), Chinese CDC, National Institutes of Health (NIH) Office of Dietary Supplements (ODS), and NCI Division of Cancer Control and Population Sciences (DCCPS), Division of Cancer Epidemiology and Genetics (DCEG), and CGH. CFCS is a pilot study that followed-up a sample of a cohort of women and their offspring enrolled in the Community Intervention Study (1993-1995) of folic acid supplementation to prevent neural tube defects in China.
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Chronic Fatigue Syndrome Advisory Committee (CFSAC)
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Committee, Work group, Advisory group, or Task Force
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AHRQ, CDC, CMS, FDA, HRSA, OS
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NINDS
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The Chronic Fatigue Syndrome Advisory Committee (CFSAC) provides advice and recommendations to the Secretary of Health and Human Services via the Assistant Secretary for Health of the US Department of Health and Human Services on issues related to myalgic encephalomyelitis and chronic fatigue syndrome (ME/CFS). These include: 1) factors affecting access and care for persons with ME/CFS; 2) the science and definition of ME/CFS; and 3) broader public health, clinical, research, and educational issues related to ME/CFS.
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Circulating Estrogens, Androgens, and Progestogens and Risk of Breast Cancer in the PLCO Cohort
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Research Initiative
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CDC
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NCI
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In a stratified cohort study of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), restricted to postmenopausal women not on menopausal hormone therapy, we are using a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay recently developed by the Centers for Disease Control and Prevention (CDC) to assess prediagnostic circulating levels of the endogenous steroid hormones believed to be involved in breast cancer etiology. Although it is known that endogenous hormones play a critical role in the etiology of breast cancer, the interrelationships among estrogens, androgens, and progesterone in determining risk are not well understood.
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Clinical and Translational Research Course for PhD Students
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Training Initiative
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FDA
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CC, NCATS, NCI, NHLBI, NIAID, NIDA, NIDCR, NIDDK, NIGMS, NIMH, NINDS
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The Clinical and Translational Research Course for PhD Students is a two-week intensive introductory course for graduate students in the basic biomedical sciences who have at least one year of graduate study. The purpose of the course is to demonstrate and highlight the roles of PhD scientists in clinical and translational research, to provide an overview and examples of how basic science and clinical observations lead to translational research, and to increase awareness and access to PhD role models, research resources, and potential career opportunities at the NIH.
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Clinical Decision Support (CDS) Federal Collaboratory and Inventory of Federal Clinical Decision Support Activities
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Committee, Work group, Advisory group, or Task Force
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AHRQ, CDC, HRSA, IHS, OS
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NLM, CC
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A federal community of interest focused on clinical decision support (CDS), and a compilation of project summaries describing CDS activities that are either funded by the US Federal government or that are being executed by agencies of the government. CDS encompasses a variety of tools and technologies that are used within electronic clinical information systems to improve the quality, safety, efficiency, and effectiveness of patient care. CDS provides clinicians, staff, patients, and other key decision makers with knowledge and person-specific information, intelligently filtered at appropriate times, to enhance health and health care. CDS encompasses computerized alerts and reminders, clinical guidelines, order sets, order entry feedback, patient data reports and dashboards, documentation templates, diagnostic support, and the presentation of contextually relevant reference information within clinical information systems. NLM has submitted to the Collaboratory and Inventory summaries of NLM projects involving Clinical Decision Support.
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Clinical Investigator Interagency Working Group for the Development of Antiviral Influenza Therapeutics
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Committee, Work group, Advisory group, or Task Force
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CDC, FDA
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NIAID
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This working group discusses a range of issues relevant to the development of antiviral drugs for the treatment of influenza.
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Clinical Islet Transplantation Consortium
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Research Initiative
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CMS, FDA
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NIDDK, NIAID
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The Clinical Islet Transplantation (CIT) Consortium is a network of clinical centers and a data coordinating center established in 2004 to conduct studies of islet transplantation in people with type 1 diabetes. Studies conducted by the CIT Consortium will focus on improving the safety and long-term success of methods for transplanting islets, the insulin-producing cells of the pancreas, in people whose own islets have been destroyed by the autoimmune process that characterizes type 1 diabetes. One clinical trial, in particular, is studying the efficacy of islet transplantation after kidney transplantation. Participants may include Medicare beneficiaries. This study was mandated in the Medicare Prescription Drug, Improvement, and Modernization Act of 2003.
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