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Naval Research Laboratories XRAY Crystallography
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Committee, Work group, Advisory group, or Task Force
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FDA
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NIDA
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The Crystallographic Studies Group at the Naval Research Laboratories provides definitive, three-dimensional structural parameters of compound samples submitted by NIDA grantees, contractors and researchers in drug abuse. Data derived from X-ray crystallographic analysis is used to confirm complex structures in drug development. Researchers use this data for publications, grant applications and patent submissions.
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NBS Implementation Plans Joint Capabilities Plans-Clinical Research Capacity
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Committee, Work group, Advisory group, or Task Force
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ASPR, FDA
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NIAID
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Several JCP WG to inform implementation
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NCATS Toolkit for Patient-focused Therapy Development
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Resource Development
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FDA
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NCATS
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NCATS is dedicated to engaging the patient community throughout the translational science process. The NCATS Toolkit for Patient-Focused Therapy Development (Toolkit) was created to provide a collection of online resources that can help patient groups advance through the process of therapy development and provide them with the tools they need to advance medical research. Launched in September 2017, the Toolkit includes resources that have been developed primarily for the rare diseases community to facilitate therapeutics research and development.
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NCATS-VA Partnership
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Other
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Not Reported
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NCATS
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Collaboration with the Veterans Health Administration representatives (VA Clinical Studies Program Director and Network of Dedicated Enrollment Sites-NODES Associate directors) on matters related to the CTSA program and co-located VHA centers.
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NCHS-CDC NHIS Hearing and Balance Supplement
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Health Survey
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CDC
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NIDCD
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This agreement pays a portion of all costs associated with the implementation of the 2023 National Health Interview Survey (NHIS) questions on hearing and balance disorders. The implementation functions include but are not limited to: (a) sample design and maintenance; (b) questionnaire design and testing; (c) interviewer training and data collection; (d) post data collection and processing; (e) oversight and management of the operations; (f) data weighting and estimation; (g) preparation and submission of all OMB and IRB packages; and (h) preparation of Public Use Data Files. Many of these functions are provided via collaborative agreement between NCHS, CDC with the U.S. Census Bureau. In addition to the above mentioned tasks, NCHS will collaborate with NIDCD to develop the hearing and balance questions. NCHS retains the right to final approval of the content of the supplementary questions, with the objective of maintaining quality, appropriateness, and cohesiveness of the entire survey.How can the data be analyzed? (e.g., national estimate; subgroup analyses; as a covariate itself for other estimates, etc.)All the above—national estimates, subgroup analyses, covariates for other estimates, etc. The data will be analyzed to provide national estimates for objectives established in Healthy People 2030 and for assessing the burden of disease associated with impairments and disabilities resulting from hearing loss, bothersome tinnitus, and balance/vestibular disorders. Subgroup analyses will be performed to examine health disparities and associations with other significant disease processes. These cross-sectional data will also be used in analyses of trends over time to assess progress in increasing access and utilization of healthcare for people with hearing, balance, and related disorders.
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NCHS-CDC NHIS Taste & Smell and NHIS Voice, Speech, and Language Questionnaire Supplements
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Health Survey
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CDC
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NIDCD
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To provide support to the National Center for Health Statistics (NCHS), CDC for implementation of a nationally representative health interview survey questions inquiring about taste smell and communication disorders and disabilities of voice, swallowing, speech, and language in both childhood and adults. Communication disabilities, including voice, swallowing, speech, and language disabilities, can profoundly affect a person’s life and health; impacting the ability to work, interact socially and engage during health care encounters. Adults with communication disabilities are at risk for decreased quality of life, health status, and health care services received. Targeted interventions delivered in a community or medical setting, including speech-language pathology services, and occupational support can potentially mitigate these risks. Few current epidemiological studies have explored the prevalence of communication disorders and their associated etiologies in the United States. While voice, swallowing, speech, and language disorders are distinct disabilities with different biological mechanisms, they can all cause a person to have difficulty communicating and thus are collectively referred to as communication disorders. Multiple national surveys, including the American Community Survey (ACS), the Current Population Survey – Annual Social and Economic Supplement (CPS-ASEC), and the Decennial Census of Population and Housing, collect information on the prevalence of disability in the United States, but these surveys do not specifically identify or distinguish between voice, swallowing, speech, and language disorders.
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NCHS-CDC-NHANES, Audiometry, Balance, and Words in Noise Component
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Health Survey
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CDC
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NIDCD
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To provide support to the National Center for Health Statistics (NCHS), CDC for balance/vestibular testing and related questions on balance and dizziness problems in the U.S. population aged 40+ years.in the National Health and Nutrition Examination Survey (NHANES Epidemiology Survey), 2018 (pilot testing) and 2019-2020 (implementation). In addition, the Audiometry Component of NHANES 2019-2020 will be augmented with a Word in Noise test administered to older adults, 70+ years of age. The prevalence of balance disorders in the US is high and increases with age. Data from NHANES 2000-2004 epidemiological survey indicate that 35.4% (69 million) US adults aged 40 or older have some balance dysfunction; prevalence jumps to 69% among those aged 70-79 years and 85% among those aged 80+ years. The higher risk of balance impairments among the elderly is due to functional changes associated with aging. The control of balance becomes increasingly dependent on visual and proprioceptive cues as we age, making the elderly more vulnerable to falls when those orientation cues are degraded. Individuals with balance trouble have a six-fold increase in the risk of falling; fall risk increases even further among individuals who report symptoms of dizziness. Falls are the leading cause of both fatal and nonfatal injuries among older adults (aged 65 years and older). In 2014, approximately 3 million older adults sought treatment in emergency rooms for fall-related injuries; 800,000 of these patients required hospitalization and 27,000 patients died. Direct medical costs of falls in the US in 2000 were more than $19 billion. Many people who fall develop a fear of falling, even if they are not injured. This fear may cause them to limit their activities leading to reduced mobility and loss of physical fitness, which in turn increases their actual risk of falling. In addition to the elderly, several other groups are at increased risk for balance disorders. Race other than white, lower educational status, diabetes, and hearing loss is associated with poorer balance function. In addition, individuals who have sustained head injuries are likely to suffer from problems with balance and dizziness.
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NCI Cancer Data Standards Repository and Registry (caDSR)
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Committee, Work group, Advisory group, or Task Force
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ASPE, FDA
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CIT, NCATS, NCI, NEI, NHLBI, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIMH, NINDS, NLM
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The National Cancer Institute (NCI) is collaborating with other NIH institutes to develop and harmonize data standards across NCI and others NIH institutes for basic, translational and clinical research, clinical care, epidemiology, public health, administration, and public information. NCI caDSR provides services to meet NCI needs, and works with other NIH institutes to reuse/share existing content.
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NCI Cervical Cancer "Last Mile" Initiative
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Research Initiative
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CDC, FDA, HRSA
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NCI
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The NCI Cervical Cancer ‘Last Mile’ Initiative (LMI) is a public private partnership between several stakeholders (including federal agencies, industry partners, and professional societies/clinical practice guidelines organizations) to validate self-sampling-based HPV testing approaches as comparable (non-inferior) alternatives to provider-collected cervical specimen for HPV testing in cervical cancer screening, and accelerate progress towards regulatory approvals.
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NCI Clinical Trials and Translational Research Advisory Committee (CTAC)
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Committee, Work group, Advisory group, or Task Force
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CMS, FDA
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NCI
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The Clinical Trials and Translational Research Advisory Committee makes recommendations on the National Cancer Institute-supported national clinical trials enterprise to build a strong scientific infrastructure by bringing together a broadly developed and engaged coalition of stakeholders involved in the clinical trial process. The Committee will provide advice on matters related to the conduct, oversight, and implementation of clinical trials and translational research across the Institute.
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