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OS PCORTF Leadership Council
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Committee, Work group, Advisory group, or Task Force
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AHRQ, CDC, CMS, FDA, HRSA, OS
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OD/OSP, NCCIH, OD/DPCPSI/ODP, OD/OER
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The Patient Protection and Affordable Care Act of 2010 created the Patient-Centered Outcomes Research Trust Fund (PCORTF) to help build the national capacity and infrastructure needed to conduct patient-centered outcomes research (PCOR), and to enable PCOR findings to be integrated into clinical practice. The Office of the Secretary (OS) of the US Department of Health and Human Services (HHS) receives 4 percent of the PCORTF to build data capacity for PCOR. ASPE convenes a Leadership Council of HHS principals or their designees to develop a strategy for use of these funds and to determine yearly investments
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Osteoporosis and Related Bone Diseases—National Resource Center
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Resource Development
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OS
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NIAMS, NIA, NICHD, NIDCR, NIDDK, OD/DPCPSI/ORWH
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Provides patients, health professionals, and the public with an important link to resources and information on metabolic bone diseases, including osteoporosis, Paget’s disease of the bone, and osteogenesis imperfecta.
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OSTP Interagency Working Group on Medical Imaging
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Committee, Work group, Advisory group, or Task Force
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CMS, FDA
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NIBIB, NCI, NIAMS, NICHD, NIDDK
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The IWMI is co-chaired by NIH and NIST and is working to identify gaps and develop a roadmap to accelerate technology development that is more effective, improves patient care, and has the potential to lower cost. The working group, which includes twelve federal agencies, has determined key strategic directions through a series of stakeholder meetings. Areas identified as important for joint focus include deep/machine learning, quantitative and high-value imaging, and inter-agency collaboration to accelerate translation. The working group released its final report on December 22, 2017. As of February 2018, the charter for this working group will not be renewed.
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P63, P13K and RAS oncogenes in tumorigenesis, immune deregulation and therapy of squamous cell carcinoma
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Research Initiative
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FDA
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NIDCD
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At the FDA, Dr. Weinberg is transducing murine keratinocytes with combinations of oncogenes found in human squamous cell carcinomas to determine if they generate transformation and tumors in laboratory conditions. Dr. Van Waes’ laboratory at NIDCD will study how these oncogene-driven tumors in mice deregulate keratinocytes and host immune responses, as well as response to various standard, molecular, and immune therapies.
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Palliative Care: Maximizing Patient Preferences and Cost Savings
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Research Initiative
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AHRQ
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CC
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The goal of the study is to provide rational, patient-defined, evidence-based recommendations to inform the redesign of the Medicare hospice benefit, transitioning policy from the current hospice benefit to a more patient-centered palliative care model.
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Partners in Information Access for the Public Health Workforce
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Resource Development
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AHRQ, CDC, HRSA, OS
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NLM
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Partners in Information Access for the Public Health Workforce is a collaboration of US government agencies, public health organizations, and health sciences libraries that provides timely, convenient access to selected public health resources on the Internet.
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Partnership for Tuberculosis (TB) and TB/HIV Research -2
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Resource Development
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CDC
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NIAID
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Support for whole genome sequencing (WGS) of isolates and bioinformatics/analytic support for WGS to characterize TB drug resistance mutations. This is a joint CDC/NIAID effort to develop a comprehensive database of resistance polymorphisms and phenotypic correlations from clinical samples from various sites worldwide.
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Partnerships for Accelerating Cancer Therapies (PACT)
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Other
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FDA
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OD/OSP, NCI
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The Partnership for Accelerating Cancer Therapies (PACT) is a public-private partnership between NIH, FDA, the private sector, foundations, and cancer advocacy organizations to accelerate progress in cancer research and bring cancer therapies to patients in less time as part of the Cancer Moonshot. Following in the models of successful existing partnerships, PACT will support jointly funded research through a collaborative decision-making structure and ensure open data sharing with partners and the public.
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Pathogen Detection Project and Interagency Collaboration on Genomics for Food and Feed Safety (Gen-FS)
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Resource Development
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CDC, FDA
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NLM
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The Pathogen Detection Project is a multi-agency collaboration that is combining data from pathogen outbreaks with other information to determine the major source of contamination. The project is conducted via a centralized system that integrates sequence data for bacterial pathogens obtained from food, the environment, and human patients. A number of public health agencies in the US and internationally are collecting samples from these sources to facilitate active, real-time surveillance of pathogens and foodborne disease. The agencies sequence the samples and submit the data to NCBI/NLM/NIH, which analyzes the sequences against others in its database to identify closely related sequences. The aim is to uncover potential sources of contamination by linking isolates from food or the environment to human illness and to quickly report the sequence relationships to public health scientists in order to aid traceback investigations and outbreak response. Collaborating agencies include FDA, CDC, USDA-Food Safety and Inspection Service, and Public Health England. The US agencies formalized their collaboration in a charter document (Interagency Collaboration on Genomics for Food and Feed Safety (Gen-FS)) that includes coordinating activities on antimicrobial resistance.
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Pathways to Prevention (P2P) Workshop Program
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Meeting/ Workshop
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AHRQ
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OD/DPCPSI/ODP
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The Pathways to Prevention (P2P) program is a workshop series hosted by the Office of Disease Prevention (ODP) to identify research gaps in a selected scientific area, identify methodological and scientific weaknesses in that scientific area, suggest research needs, and move the field forward through an unbiased, evidence-based assessment of a complex public health issue. P2P workshops are designed for topics that have incomplete or underdeveloped research and for which it is difficult to produce a report synthesizing published literature. ODP collaborates with various NIH ICs and Offices as well as other federal partners to sponsor the workshops.
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