|
Digital Quantitation of Plasma Cells in Marrow Biopsies
|
Research Initiative
|
FDA
|
CC
|
Collaboration with M Choi, WC Cheng and A Badano from the Imaging Physics Lab, Div of Imaging and Applied Mathematics Office of Science and Engineering Labs, Center for Devices and Radiological Health, FDA. The project consists of developing software and establish validations for the automated determination of marrow cellularity and enumeration of plasma cells identified by immunohistochemistry (IHC) using a CD138 antibody. This initial effort should serve as proof of principle for a broader plan to utilize IHC-based automated quantitation of different types of cells in bone marrow core biopsies for diagnosis, prognosis and therapy monitoring of marrow disorders.
|
|
Disaster Research Response Project
|
Research Initiative
|
ATSDR, CDC, FDA, OS
|
NIEHS, NLM
|
The NIH Disaster Research Response (DR2) Project is a pilot project aimed at creating an environmental health disaster research system through platforms of ready-to-go research data collection tools and a network of specially trained research responders. This project was developed and will be administered by the NIEHS and NLM. Elements of the system include epidemiologic questionnaires and clinical protocols, specially trained disaster researchers, environmental health disaster research networks, a reach-back roster of subject matter experts, and a support infrastructure that can be activated and deployed during public health emergencies and declared disasters. This effort will not only serve as a model for enhancing environmental health research responses, but will also provide invaluable lessons and platforms for others interested in advancing timely post-disaster research activities.
|
|
Domestic Scheduling to Control New Drugs of Abuse, with NIDA-Funded Testing Conducted in Support of DEA Scheduling Recommendations to the FDA
|
Research Initiative
|
FDA, OS
|
NIDA
|
HHS depends upon NIDA contracts to generate the in vitro and animal behavioral data that are required to support the domestic scheduling of new street drugs. The long-standing agreement is that DEA provides the drugs (or the funds to cover drug synthesis) to NIDA, and NIDA covers the cost of pharmacological testing.
|
|
Dominantly Inherited Alzheimer''s Network (DIAN): International Network for the Identification, Evaluation, and Follow up of Families with Early Onset of Dominantly Inherited Alzheimer''s Disease
|
Research Initiative
|
FDA
|
NIA
|
This collaboration aims to set up an international network consisting of a consortium of scientific investigators that will have the responsibility to identify, recruit, evaluate, and follow-up individuals from families with early onset dominantly inherited Alzheimer’s disease [i.e., families with the amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2) mutations or duplications or others still to be discovered].
|
|
Drug Induced Liver Injury Network (DILIN)
|
Committee, Work group, Advisory group, or Task Force
|
FDA
|
NIDDK
|
Both a prospective and retrospective database containing cases of drug-induced liver disease, DILIN is funded by a cooperative agreement and includes eight clinical centers and a central data coordinating center. One of the goals of DILIN is to establish a database of well-characterized cases of drug-induced liver injury along with serum, DNA, and tissue samples that will facilitate research on the mechanisms of hepatic injury due to drugs. Cases of liver injury due to herbal medications are also included. DILIN will develop standardized definitions of drug-induced liver disease and standardization of scoring systems for causality. Three employees of FDA serve as ad hoc members on the committee overseeing the network activities.
|
|
Early Hearing Detection and Intervention
|
Meeting/ Workshop
|
CDC
|
NIDCD
|
Teleconference sponsored by CDC.
|
|
Early Learning Interagency Policy Board (IPB)
|
Committee, Work group, Advisory group, or Task Force
|
ACF
|
NICHD, NIDA
|
The purpose of the Early Learning Interagency Policy Board is to coordinate and align efforts, where possible, around early learning and development, across the Department of Health and Human Services and the Department of Education.
|
|
Electronic Research Administration (eRA)
|
Other
|
AHRQ, CDC, FDA, SAMHSA
|
OD/OER, CSR, FIC, NCATS, NCCAM, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM
|
The Electronic Research Administration (eRA) provides information technology solutions and support for the full life cycle of grants administration functions for the NIH as well as the Agency for Healthcare Research and Quality (AHRQ), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), the Substance Abuse and Mental Health Services Administration (SAMHSA), and the Veterans Health Administration (VHA). eRA offers vital solutions to manage the receipt, processing, review, award and monitoring of over $30 billion in research and non-research grants awarded annually by NIH and other grantor agencies in support of the collective mission of improving human health. eRA helps NIH meet a vital mission: the support of cutting-edge biomedical research via grants to scientists at universities and other research institutions. Over 4,600 NIH staff, 700 partner agency staff, and 166,000 active external users depend on eRA daily. Used by Federal staff and applicants at over 12,500 research institutions worldwide, eRA has helped eliminate the hundreds of millions of pieces of paper previously required to: • Record, review and process over 80,000 applications each year. • Support more than 3,500 review meetings held annually. • Administer more than 55,000 awarded competing and non-competing grants. • Maintain patent and invention records for 25 Federal agencies (see the iEdison website). • Support thousands of applicant interactions with the Federal Government before and after the grant award, through the eRA online interface. eRA''s focus is on supporting the mission of serviced agencies by providing tools to electronically manage and report on grants in a way that maximizes efficiencies, provides a strong and scalable infrastructure, is responsive to evolving customer needs and employs sound management controls. eRA systems align with Grants.gov (the one-stop web portal for finding and applying for federal grants), allowing for full electronic processing of grant applications from application submission through closeout of the grant award and reporting thereafter. eRA operates as a fee for service activity to OPDivs and other federal agencies.
|
|
Emergency Care Research Interagency Program Officer Working Group
|
Committee, Work group, Advisory group, or Task Force
|
HRSA
|
NICHD, NHLBI, NINDS
|
This working group aims to share common challenges in conducting emergency care research, identify innovative solutions amongst the projects in IC portfolios for common problems; discuss performance evaluation of emergency care networks; and discuss models for funding and evaluating data coordinating centers. (Ad hoc)
|
|
Emergency Preparedness, Medical Countermeasures
|
Resource Development
|
OS
|
NCI
|
NCI provides expertise in radiation biology and radiation oncology to help guide the research and development for medical countermeasures for radiation injury and for biomarkers for assessing injury, dose and who needs treatment.
|