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Trial to Assess Chelation Therapy 2 (TACT2)
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Research Initiative
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CDC
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NIDDK, NCCIH, NHLBI, NIEHS
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TACT2 is a clinical trial to determine whether intravenous 2EDTA chelation therapy in combinations with oral multivitamins or alone will reduce the risk of major cardiovascular events (such as stroke and heart attack) in patients who have already had a heart attack and who also have type 2 diabetes. NIDDK has funded trials within this research initiative.
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Trial Transparency via Registration and Results Reporting at NIH ClinicalTrials.gov
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Resource Development
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FDA
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NLM, CC, NCATS, NCCIH, NCI, NCMHD, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, OD/DPCPSI/OBSSR, OD/OER, OD/OLPA, OD/OSP
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The purpose of this trans-NIH, inter-agency collaboration is to implement legal and policy requirements related to disseminating clinical trial information and promote understanding of these requirements through engagement with and the development of resources for stakeholders. NLM collaborates with FDA, OD/OSP, OGC, and other parts of NIH to improve transparency of clinical trials via registration and results reporting at NLM's ClinicalTrials.gov through implementing regulatory requirements and NIH trial transparency policies, including the 2016 NIH Policy on the Dissemination of NIH-funded Clinical Trial Information. NLM has also collaborated with OD/OBSSR to develop resources for the behavioral and social science community to support submitting study information to ClinicalTrials.gov and with OD/OBSSR, OD/OSP, OER, OLPA, and OCPL to engage the basic science community and understand their concerns about reporting NIH-funded basic experimental studies with humans to ClinicalTrials.gov.
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Tribal Epidemiology Centers Program
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Research Initiative
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IHS, CDC
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NIMHD, OD/DPCPSI/THRO
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The Tribal Epidemiology Centers Program develops Epidemiology Centers for ongoing disease surveillance and public health infrastructure for American Indian and Alaska Native communities. NIMHD issued a funding opportunity announcement, the Collaborative Minority Health, and Health Disparities Research with Tribal Epidemiology Centers (R01 and R21 Clinical Trials Not Allowed).PAR-17-484andPAR-17-48. In addition, in 2022 NIMHD with support from the NIH Office of Data Science Strategy (ODSS) established a Resource Center for Tribal Epidemiology Centers (RC-TEC).
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Tumor Mutational Burden (TMB) Harmonization Project
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Resource Development
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FDA
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NCI
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The project conducts analytical and clinical validation studies to support a standardized method of (tumor mutational burden) TMB measurement to enable consistent TMB reporting in a clinical setting despite differences in the testing panel used.
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U.S. and Canada Human Milk Composition Initiative (HMCI)
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Committee, Work group, Advisory group, or Task Force
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CDC, FDA
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NICHD, OD/DPCPSI/ODS, NIDDK, NCI
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Coordinate and support the development of human milk composition data in the U.S. and Canada for use by federal policy, program and other stakeholders to provide nutrition and dietary guidelines, education and programs for infants.
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U.S. Breastfeeding Coalition (USBC)
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Committee, Work group, Advisory group, or Task Force
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AHRQ, CDC, HRSA, IHS, OASH
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NICHD
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The United States Breastfeeding Committee (USBC) is an independent nonprofit coalition of more than 100 influential professional, educational, and governmental organizations that share a common mission to drive collaborative efforts for policy and practices that create a landscape of breastfeeding support across the United States.
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U.S. FDA Medical Imaging Drugs Advisory Committee
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Committee, Work group, Advisory group, or Task Force
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FDA
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CC
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The Committee reviews and evaluates data concerning the safety and effectiveness of marketed and investigational human drug products for use in diagnostic and therapeutic procedures using radioactive pharmaceuticals and contrast media used in diagnostic radiology and makes appropriate recommendations to the Commissioner of Food and Drugs.
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U.S. Preventative Services Task Force (USPSTF), NIH IC Liaison Group
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Committee, Work group, Advisory group, or Task Force
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AHRQ
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NICHD, NIA, NIAID, NIMHD, NINR, OD/DPCPSI/OAR, OD/DPCPSI/ODS, OD/DPCPSI/ORWH
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Created in 1984, the U.S. Preventive Services Task Force (USPSTF or Task Force) is an independent group of national experts in prevention and evidence-based medicine that works to improve the health of all Americans by making evidence-based recommendations about clinical preventive services such as screenings, counseling services, or preventive medications. The USPSTF NIH Institutes and Centers (IC) Liaison Workgroup is made up of IC representatives who work with AHRQ to identify research needs related to the fields of preventive medicine and primary care, including internal medicine, family medicine, pediatrics, behavioral health, obstetrics/gynecology, and nursing.
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Unified Medical Language System Metathesaurus (UMLS)
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Resource Development
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AHRQ, CDC, CMS, FDA
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NLM
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The National Library of Medicine (NLM) Unified Medical Language System (UMLS) integrates and distributes key terminology, classification and coding standards, and associated resources to promote creation of more effective and interoperable biomedical information systems and services, including electronic health records. NLM ingests over 200 different medical vocabulary sources, mapping these vocabularies into a unified terminology set, and providing access to the native versions of these terminologies to enable interoperability between researchers, health professionals and health data systems. Collaborators such as NCI, AHRQ, CDC, CMS, and FDA have provided vocabularies for inclusion in the UMLS and have provided input for UMLS development and enhancements.
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Union for International Cancer Control (UICC)
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Other
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OGA
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NCI
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The Union for International Cancer Control (UICC) is the largest and oldest international cancer-fighting organisation. Founded in Geneva in 1933, UICC has over 1,200 members in 173 countries, enjoys consultative status with the United Nations (ECOSOC) and has official relations with the following institutions: WHO, IARC, IAEA, UNODC. UICC has over 60 partners, including associations working to fight cancer, as well as companies and foundations. UICC is a founding member of the NCD Alliance, McCabe Centre and ICCP. UICC’s mission is to unite and support the cancer community to reduce the global cancer burden, to promote greater equality and to ensure that the cancer control continues to be a priority in the world health and development agenda. Its main areas of activity focus on convening the world's leaders for innovative, wide-reaching, cancer-control events and initiatives; building capacity to meet regional needs; and developing awareness campaigns. The purpose of the Memorandum of Understanding (MOU) with NCI/CGH is to serve as a framework for collaboration between NCI/CGH and UICC to develop and implement joint activities to support global cancer control, leveraging each other’s expertise and experience for greater impact. The focus areas of the Collaboration:• Convening meetings and other events, such as the World Cancer Congress;• Capacity building, such as the UICC Technical Fellowships, and the UICC-led replication of the Project ECHO for Knowledge Summaries for Comprehensive Breast Cancer Control;• Knowledge, advocacy and policy, such as scientific collaboration on the TNM cancer staging system and tobacco control, and the International Cancer Control Partnership (ICCP); and• Additional areas mutually identified by the Participants.
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