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Genomic epidemiology of norovirus GII.4 globally
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Research Initiative
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FDA
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FIC
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Collaboration with Dr. Gabriel Parra's team at FDA. His group has compiled a global genomic dataset of thousands of norovirus GII.4 genomic sequences spanning 37 years of sampling. Dr. Nidia Trovao's team at the NIH/FIC will employ molecular epidemiology concepts and phylodynamic modeling to shed light on the viral evolutionary history and transmission dynamics. We will also gain insight into the viral diversity circulating across countries/regions, how the viral effective population size changes over time, and identify source-to-sink patterns in norovirus GII.4 spread. This will be important to inform control strategies and the development of therapeutics and vaccines.
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Global Burden of Disease U.S. Health Disparities Working Group
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Resource Development
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CDC
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NIMHD, NHLBI, NCI, NIA, OD/DPCPSI/OBSSR, NIAMS
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Through this project, the Global Burden of Disease U.S. Health Disparities Working Group at NIH aims to generate a landmark and comprehensive report and public platform with data on the Global Burden of Disease on U.S. Health Disparities by Race/Ethnicity, Sex, Age, Socioeconomic Status and Geography. The project entails producing detailed county-level estimates of disease burden stratified by race/ethnicity, socioeconomic status (SES), age, and sex for a vast array of diseases, injuries and risk factors. The report would include a broad set of measures of the burden of disease (e.g., disability-adjusted life years and healthy life expectancy). This project would result in a platform for downloadable, publicly available data review and visualization tools for extracting information on these stratified analyses at the county-level for every U.S. county. CDC/NCVS is providing guidance on vital statistics data, algorithms and procedures used to generate life expectancy estimates, etc., by race/ethnicity.
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Global Environmental and Occupational Health (GEOHealth)
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Research Initiative
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CDC
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NIEHS, FIC, NCI, OD/DPCPSI/ORWH
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The Global Environmental and Occupational Health (GEOHealth) program supports the development of institutions in low- or middle-income countries (LMICs) serving as regional hubs for collaborative research, data management, training, curriculum and outreach material development, and policy support around high-priority local, national and regional environmental and occupational health threats.
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Global Health Security Agenda (GHSA) Action Package Prevent 3 (APP3), Biosafety and Biosecurity Working Group
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Committee, Work group, Advisory group, or Task Force
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CDC, OS
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OD/OSP
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Promotes awareness and implementation of comprehensive national-level biosafety and biosecurity frameworks within the Global Health Security Agenda.
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Global Initiative for Cancer Registry Development (GICR)
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Committee, Work group, Advisory group, or Task Force
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CDC
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NCI
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Cancer incidence and mortality are rising rapidly worldwide, particularly in low- and middle-income countries. There is an overwhelming need for countries to adopt and implement cancer control actions. Yet only one in five low- and middle-income countries have the necessary data to drive policy and reduce the burden and suffering due to cancer. The Global Initiative for Cancer Registry Development (GICR) is a coordinated, multi-partner approach to deliver the required change. Its objective is to make cancer data count. NCI partners with the U.S. Centers for Disease Control and Prevention to provide technical and financial support to the Caribbean Hub of GICR.
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Global Nutrition Coordination Plan (GNCP)
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Committee, Work group, Advisory group, or Task Force
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CDC, OGA, FDA
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FIC, NICHD, NCI
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The U.S. Government Global Nutrition Coordination Plan is an interagency effort to strengthen the impact of the many diverse nutrition investments across the U.S. Government through better communication and collaboration and by linking research to program implementation. Through coordination mechanisms, the U.S. Government is working to maximize its support to country-led programs, continue its global leadership and partnerships, and generate, share, and apply knowledge and evidence in the nutrition sector in order to accelerate progress toward shared nutrition goals. At the forefront of the Coordination Plan is the recognition that, as stewards of American investments, U.S. Government agencies must ensure that these investments are used in the most efficient and impactful way possible.
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Global Substance Registration System (GSRS)
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Research Initiative
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FDA
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NCATS, OD/OIR
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GSRS is a public software and web application that supports the registration and documentation of substances found in medicinal products. Importantly, the definition of substances is based on a global and consistent definition (ISO 11238 standard). The software has been heavily utilized at the FDA since 2016, and has also been adopted by other regulatory agencies around the world, such as EMA (European Medicines Agency), BfArM (Federal Institute for Drugs and Medical Devices) and WHO-UMC. NCATS provides access to a public instance of the software, and to the latest publicly available data on substance definitions and properties, as provided by the FDA, for use by the broader translational research community.
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GlycoBiology Scientific Interest Group
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Committee, Work group, Advisory group, or Task Force
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FDA
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NCI, NHGRI, NHLBI, NIAID, NICHD, NIDCR, NIDDK, NIGMS
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A core group of laboratories representing several institutes and the FDA, form the postdoctoral training laboratories of the Glycobiology SIG. Laboratory training is augmented with a Special Topics in Glycobiology Course, a seminar series and an annual NIH FDA Glycosciences Research Day held each spring that highlights work being done locally in the glycosciences. A Steering Committee composed of both intra and extramural NIH, FDA, NIST and DOE scientists organize the SIGs activities.
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Government-University-Industry Research Roundtable (GUIRR)
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Committee, Work group, Advisory group, or Task Force
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FDA
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NCATS, OD/IMOD
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The National Academies of Sciences, Engineering, and Medicine Government-University-Industry Research Roundtable is charged with improving the research enterprise of the United States by successfully resolving the cross-sectoral issues that prevent the U.S. research enterprise from reaching its full potential. This mission is achieved by convening senior-most representatives from government, universities, and industry to frame the critical issues, followed – when appropriate – by the execution of activities designed to address specific cross-sectoral impediments to achieving a healthy, vibrant research enterprise. GUIRR provides a unique forum for dialogue among top government, university and industry leaders of the national science and technology enterprise.
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H-CORE
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Committee, Work group, Advisory group, or Task Force
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ASPR/BARDA
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NIAID
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Conduct and coordinate preclinical activities to help facilitate the development of formerly Operation Warp Speed (OWS) vaccine candidates (etc., animal models, testing, and correlates of protection studies)
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