|
P63, P13K and RAS oncogenes in tumorigenesis, immune deregulation and therapy of squamous cell carcinoma
|
Research Initiative
|
FDA
|
NIDCD
|
At the Food and Drug Administration (FDA), Dr. Weinberg is transducing murine keratinocytes with combinations of oncogenes found in human squamous cell carcinomas to determine if they generate transformation and tumors in laboratory conditions. Dr. Van Waes’ laboratory at the National Institute on Deafness and Other Communication Disorders (NIDCD) will study how these oncogene-driven tumors in mice deregulate keratinocytes and host immune responses, as well as response to various standard, molecular, and immune therapies.
|
|
Pathogen Detection Project and Interagency Collaboration on Genomics for Food and Feed Safety (Gen-FS)
|
Resource Development
|
CDC, FDA
|
NLM
|
The Pathogen Detection Project is a multi-agency collaboration that is combining data from pathogen outbreaks with other information to determine the major source of contamination. The project is conducted via a centralized system that integrates sequence data for bacterial pathogens obtained from food, the environment, and human patients. A number of public health agencies in the US and internationally are collecting samples from these sources to facilitate active, real-time surveillance of pathogens and foodborne disease. The agencies sequence the samples and submit the data to the National Center for Biotechnology Information (NCBI), a division of the National Library of Medicine (NLM) at the National Institutes of Health (NIH), which analyzes the sequences against others in its database to identify closely related sequences. The aim is to uncover potential sources of contamination by linking isolates from food or the environment to human illness and to quickly report the sequence relationships to public health scientists in order to aid traceback investigations and outbreak response. Collaborating agencies include the Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), USDA-Food Safety and Inspection Service, and Public Health England. The US agencies formalized their collaboration in a charter document (Interagency Collaboration on Genomics for Food and Feed Safety (Gen-FS)) that includes coordinating activities on antimicrobial resistance.
|
|
Pathways to Prevention (P2P) Workshop Program
|
Meeting/ Workshop
|
AHRQ
|
ODP
|
The Pathways to Prevention (P2P) program is a workshop series hosted by the Office of Disease Prevention (ODP) to identify research gaps in a selected scientific area, identify methodological and scientific weaknesses in that scientific area, suggest research needs, and move the field forward through an unbiased, evidence-based assessment of a complex public health issue. P2P workshops are designed for topics that have incomplete or underdeveloped research and for which there is a need for a systematic evidence review that synthesizes the published literature. After each workshop, ODP also organizes a meeting of all Federal Partners who have an interest in or activities related to the workshop topic to discuss ways that the Federal Partners might collaborate to implement workshop recommendations.
|
|
Patient Centered Outcomes Research Trust Fund Leadership Council (OS-PCORTF LC)
|
Committee, Work group, Advisory group, or Task Force
|
ASPE, CMS, AHRQ, ACF, ACL, CDC, FDA, HRSA, ONC, IHS
|
NLM, NCCIH, OD/DPCPSI, OD/OER
|
This council provides for the coordination of relevant Federal health programs to build data capacity for comparative clinical effectiveness research, including the development and use of clinical registries and health outcomes research networks, in order to develop and maintain interoperable data network to collect and analyze data on outcomes and effectiveness from multiple sources.
|
|
PCC Technical Working Group on PFAS
|
Committee, Work group, Advisory group, or Task Force
|
CDC, FDA, ATSDR
|
NIEHS
|
Technical coordination on toxicology,exposure,analysis, mitigation of PFAS
|
|
PCORTF Frailty & Functional Disabilities Project Working Group
|
Resource Development
|
ASPE, AHRQ, CDC, CMS
|
NIA
|
Validate and Expand Claims-Based Algorithms, Identifying Patients with Frailty and Functional Disabilities across Payer and Patient Populations
|
|
Pediatric COVID-19/Multisystem Inflammatory Syndrome in Children (MIS-C) interagency team
|
Committee, Work group, Advisory group, or Task Force
|
CDC, FDA, HRSA
|
NIAID, NHLBI, NICHD
|
Inter-agency review of current status of HHS efforts to address pediatric Sars-CoV-2 infection
|
|
Pediatric Device Consortia Grants Program
|
Research Initiative
|
FDA
|
NICHD
|
The goal of the Food and Drug Administration (FDA) Pediatric Device Consortia (PDC) Grants Program is to facilitate the development, production, and distribution of pediatric medical devices through funding of nonprofit consortia.
|
|
Phylodynamic Monitoring of HIV Transmission Hotspots to End the HIV Epidemic
|
Meeting/ Workshop
|
CDC
|
NIAID, NLM
|
This workshop brought together NIAID grantees, NIH and CDC officials, and people living with HIV to discuss the use and implementation of phylogenetic tools to support the Ending the HIV Epidemic: A Plan for America (EHE) initiative. The workshop featured scientific presentations on HIV phylogenetics, bioinformatics/mathematical modeling, and HIV prevention and transmission, as well as a panel discussion to highlight community perspectives on the responsible use of phylogenetic data to identify HIV transmission hotspots.
|
|
Pillbox
|
Resource Development
|
FDA
|
NLM
|
The National Library of Medicine and the Food and Drug Administration have established a collaborative relationship to enhance patient safety through the linking of digital images of prescription solid dosage form medications to the Structured Product Labeling (SPL) files and the substance information of those pharmaceuticals.
|