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Preclinical Assessment of Phage Therapy for Pathogen Decolonization
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Research Initiative
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FDA
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NIAID
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This project addresses key regulatory considerations relevant to using bacteriophages for decolonization of the drug-resistant nosocomial pathogens, vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). These include characterizing pathogen resistance to phage, defining phage mixtures ("cocktails") to circumvent resistance, optimizing mouse models to evaluate pathogen decolonization, and identifying endpoints that support claims for clinical benefit (e.g., reduced risk of disease transmission).
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Pregnancy and Birth to 24 Months (P/B-24) Project''s Federal Expert Group
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Committee, Work group, Advisory group, or Task Force
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CDC, FDA, HRSA, OS
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NICHD, NCI, NHLBI, NIDDK
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In 2012, the US Department of Agriculture (USDA) and Department of Health and Human Services (HHS) initiated a project informally called the “B-24 project.” This multi-phase project was originally intended to conclude in 2018 with information that could help the Departments develop dietary recommendations for infants and toddlers for release separate from the Dietary Guidelines. The first phase was completed in 2012-2013.
In February 2014, Congress passed the Agricultural Act of 2014, also known as the Farm Bill, mandating that the Dietary Guidelines expand to include dietary guidance for infants and toddlers (from birth to age 24 months), as well as women who are pregnant, beginning with the 2020-2025 edition. Thus, USDA and HHS adjusted the purpose, timeline, and scope of the project. Now called the “Pregnancy and Birth to 24 Months project” or “P/B-24 project” to reflect the addition of pregnant women, this project is a joint initiative led by USDA and HHS in collaboration with programmatic and scientific experts. Rather than concluding in 2018 with dietary recommendations, the goal of the current project is to begin examining topics of public health importance for women who are pregnant and infants and toddlers from birth to 24 months of age. The findings from this work will be made publicly available at the completion of the project.
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PregSource® Management Team
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Public Education Campaign
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CDC, HRSA
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NICHD, NCCIH, NHLBI, NIEHS, NIMHD, NINR, OD/DPCPSI/OBSSR, OD/DPCPSI/ORWH
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PregSource is a crowdsourcing research project that aims to learn about the pregnancy experience. Getting information directly from pregnant women about what they feel, think, do, and experience during pregnancy and after giving birth can teach us more about pregnancy and how to improve care.
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Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB)
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Committee, Work group, Advisory group, or Task Force
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BARDA
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NIAID
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In March 2015, the Department of Health and Human Services (HHS) announced the establishment of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB). This Federal Advisory Committee (FACA) includes public voting members, non-voting liaison representatives from organizations and/or interest groups, and non-voting federal ex-officio members. PACCARB provides advice, information, and recommendations to the Secretary regarding programs and policies intended to support and evaluate the implementation of Executive Order 13676, including the National Strategy for CARB and the National Action Plan for CARB. PACCARB has been reauthorized until Jan 18, 2019 (based on its charter), through Executive Order 13811 on Sept. 29, 2017.
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President’s Emergency Plan for AIDS Relief (PEPFAR) Implementation Science/Combination Prevention
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Research Initiative
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CDC
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NIAID, FIC, NCI, NIAAA, NIDA, NIMH, OD/DPCPSI/OAR
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This President’s Emergency Plan for AIDS Relief (PEPFAR) activity focuses on testing treatment as prevention on the population level in South Africa and Zambia. This activity was initiated through the HIV Prevention Trials Network (HPTN), with support of multiple National Institutes of Health (NIH) Institutes and Centers, PEFPAR, and the Bill & Melinda Gates Foundation. The Requests for Application (RFA) was issued concurrently with a Centers for Disease Control and Prevention (CDC) RFA for combination prevention, and the agencies have worked together to ensure that the studies are complementary and do not overlap.
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President’s Task Force on Environmental Health Risks and Safety Risks to Children: Lead Exposures Subcommittee
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Committee, Work group, Advisory group, or Task Force
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ACF, CDC, FDA, HRSA, OS
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NICHD, NHLBI, NIEHS, OD/DPCPSI/ODP
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The President''s Task Force on Environmental Health and Safety Risks to Children is the focal point for coordinating the federal government''s effort to explore, understand, and improve children''s environmental health. The task force''s objectives are to: 1) develop federal interagency strategies to protect children’s environmental health and safety; 2) identify priority children''s environmental health and safety issues best addressed through federal interagency efforts; and 3) communicate information to federal, state, and local decision-makers to protect children from environmental health risks. The Lead Subcommittee seeks to reduce lead exposure and associated harms through collaboration among federal agencies and with a range of stakeholders, including states, tribes and local communities, along with businesses, property owners and parents. This Subcommittee will help federal agencies work strategically and collaboratively to reduce exposure to lead with the aim of ultimately improving children’s health.
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Prevention Research Centers
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Research Initiative
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CDC
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NCI
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The Prevention Research Centers program funds community-based research projects at 26 academic research centers across the United States. These centers: (1) Conduct research projects that promote health and prevent disease; (2) Build research teams of multidisciplinary faculty; (3) Seek solutions, strategies, and policies that address public health problems; (4) Participate in research networks that address priority health issues, such as healthy aging, cancer prevention & control, and obesity prevention; (5) Build long-term relationships for engaging communities as partners in research; (6) Conduct research in directions guided by advisory boards of community leaders; (7) Develop and deliver trainings that enhance the public health workforce; and (8) Conduct additional research funded by other federal agencies, foundations, and nonprofit organizations.
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Prevention Research Coordinating Committee (PRCC)
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Committee, Work group, Advisory group, or Task Force
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AHRQ, CDC, OS
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OD/DPCPSI/ODP, CC, FIC, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, OD/DPCPSI/OAR, OD/DPCPSI/OBSSR, OD/DPCPSI/ODS, OD/DPCPSI/ORWH, OD/OLPA
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The NIH Prevention Research Coordinating Committee (PRCC) serves as a venue for exchanging information on recent scientific advances in disease prevention; examining the impact of new policies on research; planning new or discussing ongoing initiatives; and highlighting program accomplishments. As a trans-National Institutes of Health (NIH), trans-agency committee, the PRCC provides a broad perspective on the current state-of-the-science and actively disseminates information about prevention-related activities sponsored by federal and non-federal organizations to the NIH Institutes and Centers.
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Probiotic and Prebiotic Working Group [PPWG]
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Committee, Work group, Advisory group, or Task Force
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FDA
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NCI, NCCIH, NIAMS, NIDA, NIDCR, OD/DPCPSI/ODS
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The Probiotic and Prebiotic Working Group (PPWG) is a trans-National Institutes of Health (NIH) effort formed in 2006 to identify gaps and challenges in prebiotic and probiotic research. Their goals include (1) facilitating interactions and collaborations among research scientists in the field of probiotics and prebiotics, (2) advancing prebiotic and probiotic research, and (3) understanding the role of gut microbiota and use of prebiotics and probiotics in health and disease. The working group strives to promote constructive interactions across NIH Institutes, Centers, and Offices, by disseminating real-time information and keeping PPWG members abreast of current and future activities occurring in the fields of probiotics and prebiotics. The group meets quarterly to form allied partnerships and collaborate on various pre- and probiotic activities.Two trans-NIH Program Announcements were released in 2015 and were renewed in 2018 (PA-18-902; PA-18-876 ).
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Project ECHO for Cancer Research and Control
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Other
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CDC
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NCI
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Project Extension for Community Healthcare Outcomes (ECHO) is a collaborative medical education model that aims to build workforce and knowledge capacity, through use of online videoconferencing to allow for knowledge exchange across interdisciplinary teams on relevant medical, healthcare, and health systems related topics. The National Cancer Institute (NCI) Center for Global Health (CGH) Project Echo Cancer Control Planning Program will link participants active in cancer control planning in low- and middle-income country settings with researchers, regional colleagues, and relevant technical experts, through monthly ECHO sessions that will provide virtual didactic instruction, case study learning, and knowledge exchange on relevant evidence-based cancer control planning principles. These sessions will relay evidence-based, general cancer control principals and related to cervical cancer screening. The CGH Project ECHO program’s primary goals are to increase participant knowledge of the aforementioned topics, improve the application of knowledge, including evidence-based practices and policies, and to increase collaboration among participants and experts who are active in cancer control planning in the participating countries.
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