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Enhanced NIH Reporting on Research Spending
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Resource Development
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CDC
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OD/OSP, OD/OER
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In early 2016, in response to a Congressional request from the FY16 Omnibus budget, NIH collaborated with the National Center for Health Statistics (NCHS) at the CDC to post federally sourced data on prevalence, from the National Health Interview Survey, and mortality, from the National Vital Statistics system, leveraging NCHS expertise to match these data sources to disease categories for which NIH reports spending totals. NIH intends to update these data on an annual basis, in regular consultation with NCHS, in order to maintain as accurate and comprehensive a dataset as possible. These data are posted alongside the RCDC spending categories on the NIH RePORT website. NIH provided mortality data for 103 RCDC categories, and prevalence for 36, out of 265 total RCDC categories.
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Evaluation of Patient Reported Outcomes Following LASIK Surgery
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Research Initiative
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FDA
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NEI
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In October 2009, the FDA, the National Eye Institute (NEI), and the Department of Defense (DoD) launched the LASIK Quality of Life Collaboration Project (LQOLCP) to help better understand the potential risk of severe problems that can result from LASIK. The project published three manuscripts in 2016 on the new questionnaire developed by the group that can be used to assess the percent of patients who develop difficulties performing their usual activities following LASIK, and to identify predictors for those patients.
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Evaluation of the Association between Maté Consumption and urinary PAH in Brazil
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Research Initiative
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CDC
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NCI
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This collaboration between CDC and NCI will measure metabolites of polycyclic aromatic hydrocarbons (PAHs) in the urine samples from individuals with different amounts of daily maté drinking.
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Executive Committee for the Interagency Committee on Disability and Rehabilitation
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Committee, Work group, Advisory group, or Task Force
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ACL, CDC, IHS, OS
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NICHD, NIMH, NINDS
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This committee was established to promote coordination and cooperation among federal departments and agencies conducting disability, independent living, and rehabilitation research programs—including those that relate to assistive technology research, and research that incorporates the principles of universal design.
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Executive Committee for the Interagency Coordinating Committee on Fetal Alcohol Spectrum Disorders (ICCFASD)
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Committee, Work group, Advisory group, or Task Force
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ACF, AHRQ, CDC, HRSA, IHS, SAMHSA
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NICHD, NIAAA, NIDA
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The Interagency Coordinating Committee on Fetal Alcohol Syndrome (ICCFASD) was created in October 1996 in response to recommendations of an expert committee of the Institute of Medicine that NIAAA chair an effort to coordinate Federal activities on Fetal Alcohol Syndrome (FAS) and other disorders associated with prenatal alcohol exposure. ICCFASD works to improve communication, cooperation, and collaboration among disciplines and federal agencies that address issues of health, education, developmental disability, research, justice, and social services relevant to FAS and related disorders caused by prenatal alcohol exposure. The ICCFASD meets twice a year and frequently arranges special conferences.
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Exposure Science in the 21st Century (ES21) Working Group
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Research Initiative
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CDC, FDA
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NIEHS, NCI
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ES21 is a working group chartered by the Toxics and Risk subcommittee of the OSTP Committee on Environment, Natural Resources, and Sustainability. The group focuses on coordinating efforts to advance exposure science through research and development. The primary emphasis is on information sharing and cataloging federal activities on biomonitoring, community engagement, data management, environmental monitoring, modeling, and the development of sensors and dosimeters.
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Extracellular Ribonucleic Acid (RNA) Communication
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Research Initiative
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FDA
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OD/DPCPSI, NCATS, OD/DPCPSI/OSC
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Recent advances have indicated that ribonucleic acids (RNAs) can play a role in a variety of complex cellular functions, including newly discovered mechanisms of cell-to-cell communication. RNA can be exported from cells in extracellular vesicles or bound to lipids or proteins, to circulate through the body and affect cells at a distance. However, the actual impact of the extracellular RNAs, or exRNAs, is currently unknown. NIH and FDA have coordinated efforts on the preclinical and clinical use of exRNAs to address human health and disease. To date, several PIs have had pre-pre-IND meetings with FDA/CBER. They have been provided information necessary to submit applications, for example, a biomarkers device.
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Extracting Adverse Reactions and Indexing the Content of Structured Product Labels (SPLs)
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Resource Development
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FDA
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NLM
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The objective of this initiative is for NLM to assist the US Food and Drug Administration (FDA) in indexing the content of structured product labels (SPL) for drugs. Natural language processing technology is used to extract drug-drug interaction information from SPLs which will be validated by FDA subject matter experts. Transforming the narrative text to structured information encoded in national standard terminologies is a prerequisite to the effective deployment of drug safety information in drug labels for clinical decision support. Starting in FY16, LHC and FDA/CDER collaborate on advancing automated extraction of Adverse Reactions (ARs) from drug listing information companies have submitted to FDA in the form of Structured Product Labels (SPLs). The goals of the initial agreement were to develop optimal MetaMap settings for extracting ARs from SPLs and provide FDA with the software necessary to replicate the results. To evaluate the extraction quality, LHC and FDA needed to develop a test collection of SPLs annotated with ARs. Working together, LHC and FDA have developed annotation guidelines. LHC have annotated 200 SPLs and coded the results to MedDRA, the official controlled vocabulary used by FDA to normalize the labeled ARs. In FY17, the collaboration continues with the goals to conduct a community-wide evaluation of the available AR extraction tools. The evaluation venue is NIST Text Analysis Conference (TAC).
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Extreme Events and the Elderly: Scientific Evidence, Cultural Considerations and Sustainable Solutions
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Meeting/ Workshop
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CDC
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NIEHS, NIA
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The purpose of this workshop was to explore research, service, and policy needs of the elderly in the context of extreme events (natural and man-made catastrophes such as hurricanes, floods, oil spills, and fires). The workshop highlighted existing resources and sustainable solutions for the elderly within the context of specific cultural needs of a variety of elderly populations (African American, Hispanic, Native American, Asian, rural/remote, and low SES elderly). This workshop was held from June 13 to 14, 2017.
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Eye Research Collaboration
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Other
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FDA
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NEI
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The National Eye Institute (NEI) is collaborating with the Food and Drug Administration (FDA) on uveitis research and on the ocular manifestations of Zika virus and Ebola virus. Uveitis is an autoimmune disease that targets the eye. If left untreated the disease can cause permanent vision loss. Current treatments consist of steroids to suppress the immune system. However, chronic use of these drugs has many side-effects and complications. Recent outbreaks of Ebola virus and Zika virus have highlighted the unique immunological responses to these infections in the “immune privileged” eye. The virus persists in ocular fluids, even after virus is cleared from other parts of the body.
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