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Collaboration With Indian Health Service Institutional Review Board (IRB) In Training IRB Interns From Native Communities
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Committee, Work group, Advisory group, or Task Force
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IHS
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CC, NHGRI
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The Clinical Center’s Department of Bioethics, in collaboration with NHGRI, piloted an Institutional Review Board (IRB) internship program for Native Americans.
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Collaborative Islet Transplant Registry Ad Hoc Scientific Advisory Committee
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Committee, Work group, Advisory group, or Task Force
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FDA, HRSA
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NIAID
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This Advisory Committee provides scientific direction to the Collaborative Islet Transplant Registry on an ad hoc basis.
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Collaborative on Healthy Parenting in Primary Care
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Committee, Work group, Advisory group, or Task Force
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CDC, SAMHSA
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NICHD
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The Collaborative on Healthy Parenting in Primary Care recognizes the accumulated evidence of the effectiveness of
family-focused prevention programs that promote the physical and behavioral health and emotional well-being of children
from before their birth through adolescence. Members of this collaborative have united around an initiative to support the
integration of effective programs that promote healthy parenting into primary care settings in order to achieve optimal
health for children.
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Collaborative Use Repurposing Engine (CURE)
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Research Initiative
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FDA
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NCATS
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CURE is a new tool designed to centrally capture and organize real-world information about how healthcare practitioners use existing drugs in novel ways to treat patients with neglected tropical diseases (NTDs), emerging infections and drug-resistant infections when treatment options are limited or inadequate. It is currently publicly available in “beta” as an open-access website that enables healthcare practitioners throughout the world to contribute to the database by using a simple online form, a smartphone or other mobile device. In addition to submitting their own case reports, practitioners are also able to query and retrieve information from the database.
Neglected Tropical Diseases (NTDs) are a group of parasitic and bacterial diseases that cause substantial illness for more than one billion people globally. Patients with NTDs, emerging or drug-resistant infections may lack adequate treatment options due to the limited number of drugs approved for these conditions. Out of necessity, healthcare practitioners try to use existing drugs in novel ways to treat these patients. At present, much of this clinical experience, regardless of whether the patient outcomes are positive or negative, is never reported or shared, and the knowledge is therefore lost.
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Common Data Elements (CDE) for Patient-Centered Outcomes Research
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Resource Development
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OS
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NLM, CC, CIT, NCATS, NCI, NEI, NHGRI, NHLBI, NIA, NIAID, NIAMS, NICHD, NIDA, NIDDK, NIEHS, NIMH, NINDS, NINR, OD/OER
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Led by NLM, a Task Force of the NIH Scientific Data Council and others are working to promote the use of common data elements in research, surveillance, and patient registries to facilitate data sharing and reuse. Work to date has produced a portal of NIH projects that use Common Data Elements (CDEs) and, with the assistance of funding to develop data infrastructure to promote patient-centered outcomes research (OS Patient-Centered Outcomes Research Trust Fund), will contribute to development of a search, retrieval, and repository mechanism that will support and reflect the standards work of the Standards & Interoperability (S&I) Framework Structured Data Capture Initiative. This project contributes to efforts to develop a repository and search tool for identification of CDEs for Patient-Centered Outcomes Research. Initially formed as a work-group of the Trans-NIH BioMedical Informatics Coordinating Committee (BMIC), and changed to SDC Task Force in 2016.
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Community Guide Screen Time Team
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Meeting/ Workshop
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CDC
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NHLBI
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The goal of the workshop was to review the evidence related to screen time and its effects on obesity and health behaviors of youth. In 2016, a review was published: Reducing Recreational Sedentary Screen Time: A Community Guide Systematic Review.
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Community Preventive Services Task Force (CPSTF)
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Committee, Work group, Advisory group, or Task Force
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CDC
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OD/DPCPSI/ODP, OD/DPCPSI
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The Community Preventive Services Task Force (CPSTF) is an independent, non-federal panel of prevention experts that conducts rigorous systematic reviews and provides public health recommendations to the CDC to inform decision-making about policy, practice, and research priorities for community preventive services. Recommendations from the CPSTF are published in The Guide to Community Preventive Services. The ODP represents NIH as an official liaison member and works with the CDC and CPSTF members to ensure that recommendations represent the views, concerns, and needs of the NIH and our constituents. ODP staff also serve on, or recommend NIH scientist to serve on, systematic review teams, and help translate CPSTF recommendations into actions.
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Computational Toxicology for NIH Medications Discovery
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Research Initiative
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FDA
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NIDA
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Through an inter-agency agreement, the FDA provides structure-activity, relationship-based toxicity predictions for compounds that are under evaluation in the NIDA Addiction Treatment Discovery Program. On a limited basis, other NIH ICs may utilize this resource by working through NIDA.
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Computer-aided Diagnosis for Radiology Images
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Research Initiative
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FDA
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CC
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The collaboration focuses on the improvement of computer-aided diagnosis for radiology images. Specific applications include computer-aided polyp detection for CT colonography, improvements in the conduct and analysis of observer performance experiments using radiology images and the use and development of advanced machine learning and receiver operating characteristics methods with application to computer-aided diagnosis.
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Conducting Comprehensive Toxicological Assessments
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Research Initiative
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FDA
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NIEHS
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The purpose of this Agreement is to conduct, at FDA/NCTR, comprehensive toxicological assessments on FDA priority chemicals/agents nominated to the National Toxicology Program. Studies can include range finding sub-chronic and chronic, compound-specific mechanistic studies, and consideration of the use of alternate test systems. This combination of studies is designed to facilitate the interpretation of study results in support of comprehensive quantitative human health risk assessments. The primary goal of this program is to develop a comprehensive scientific data base that can be utilized to reduce the uncertainty in risk assessment/risk benefit analysis for specific chemicals with high FDA impact.
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