| Investigations of Early Life Determinants of Pediatric and Adult Malignancies in a Population |
Research Initiative |
CDC |
NCI |
In collaboration with investigators from the U.S. CDC and the China CDC, NCI is assessing risk of pediatric leukemia and other pediatric cancers in a large population of offspring of mothers enrolled in a community intervention program of periconception folic acid supplementation in China. Pediatric cancer risks will be compared in offspring of mothers treated vs. offspring of mothers not treated with folic acid supplements. |
| Kaposi Sarcoma and HHV8 in Sickle Cell and Other Ugandan Populations |
Research Initiative |
CDC |
NCI |
Epidemiological studies are being conducted to assess small-area variation of HHV8 and to learn about socio-demographical and environmental risk factors for HHV8 and Kaposi sarcoma in Uganda. |
| Linking Atherosclerosis Risk in Communities (ARIC) Data to CMS Data |
Research Initiative |
CMS |
NHLBI |
The ARIC study, which began in 1985, seeks to 1) monitor trends in the incidence and mortality of coronary heart disease and heart failure through a surveillance program in four communities and 2) assess determinants in development and progression of subclinical and clinical cardiovascular disease (CVD) through a cohort follow-up study of 15,796 white and African American persons aged 45-64 at baseline. Since 2005, CMS data has been provided through an interagency agreement. The data is being used to validate and capture all the heart failure cases in persons aged 65 and older in the ARIC cohorts and to validate and capture morbidity and mortality status of these individuals. In addition, CMS data are being used to enhance ARIC CVD outcomes research by enabling researchers to study determinants related to medical care access, quality, cost, and outcomes. Conference calls are conducted among staff of the study, the CMS, and the NHLBI to discuss the data availability, confidentiality, quality, distribution, and to identify research opportunities. |
| Long-term Oxygen Treatment Trial |
Research Initiative |
CMS |
NHLBI |
The Long-term Oxygen Treatment Trial is a randomized controlled clinical trial to assess the efficacy of around-the-clock, supplemental oxygen therapy in subjects with chronic obstructive pulmonary disease and moderately severe hypoxemia. NHLBI will administer and oversee the study, and Medicare will cover the costs of items and medical services that are generally available through that program to beneficiaries enrolled in the trial. |
| Lung Cancer and Diesel Exhaust Among Non-Metal Miners (Nested Case-Control Study) |
Research Initiative |
CDC |
NCI |
A retrospective cohort mortality and nested case-control study of about 12,315 non-metal miners (278,041 person-years) to investigate risk of lung cancer in relation to quantitative measures of exposure to diesel exhaust. |
| Maintenance of an Armadillo Colony |
Research Initiative |
HRSA |
NIAID |
This contract supports basic research for leprosy. |
| Methylphenidate in Male Rhesus Monkeys |
Research Initiative |
FDA |
NICHD |
The purpose of this IAA is to utilize a structure approach to evaluate the safety of this frequently used stimulant in a developing animal model in accordance with FDA protocol E0728701. The information from these experiences will enhance our ability to conduct a safety assessment of methylphenidate in humans. |
| Modeling Infectious Disease Agent Systems (MIDAS) Committee for Methicillin-Resistant Staph |
Research Initiative |
AHRQ, CDC |
NIGMS |
Consultations and committee participation with MIDAS continues on a study of Methicillin-resistant Staphylococcus aureus (MRSA), a virulent bacterial staph infection that is highly resistant to some antibiotics, and spread among health care settings in Orange County California. |
| Models of Infectious Disease Agent Study (MIDAS) |
Research Initiative |
CDC |
NIGMS, FIC |
Models of Infectious Disease Agent Study (MIDAS) is a collaboration of research and informatics groups to develop computational models of the interactions between infectious agents and their hosts, disease spread, prediction systems and response strategies. The models will be useful to policymakers, public health workers and other researchers who want to better understand and respond to emerging infectious diseases. If a disease outbreak occurs, the MIDAS network may be called upon to develop specific models to aid public officials in their decision-making processes. |
| Multinational Influenza Seasonal Mortality Study (MISMS) Research |
Research Initiative |
OS |
FIC, NHLBI, NIAID, NLM |
MISMS was originally initiated to analyze national and global mortality patterns associated with influenza virus circulation. The focus of MISMS has since expanded to evaluate the interaction between the epidemiology, ecology, and evolutionary dynamics of influenza, including natural selection, reassortment, migration, and antigenic change. Multinational and bilateral collaborations developed by MISMS collect, analyze, and disseminate research findings through scientific publications, training workshops, and communication tools for investigators and decision-makers. Our research findings inform numerous national governments, multilateral organizations, and research stakeholders on interventions for both pandemic and seasonal influenza. To date, data have been acquired from more than 30 countries (representing ~3.2 billion people), resulting in over 100 publications. |