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Impact of Opioid-Related Emergencies on First Responders
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Research Initiative
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FDA
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CC
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Impact of Opioid-Related Emergencies on First Responders
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Implementation Research in HRSA Ryan White Sites: Screening and Treatment for Mental and Substance Use Disorders to Further the National Ending the HIV Epidemic (EHE) Goals
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Research Initiative
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HRSA
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NIMH, NIDA
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The National Institute of Mental Health (NIMH) and National Institute on Drug Abuse (NIDA) collaborated with the Health Resources and Services Administration (HRSA) HIV/AIDS Bureau to develop a research funding opportunity (RFA-MH-20-520 and RFA-MH-20-521) on methods to enhance screening and treatment for mental and substance use disorders in HRSA Ryan White HIV/AIDS Program funded sites through implementation research, in order to advance the goals of the Ending the HIV Epidemic in the U.S. initiative. The research initiative seeks to strengthen the research/service delivery collaboration between NIH grantees and HRSA-funded HIV care sites, with the goal of increasing retention in HIV care and viral suppression through implementation of evidence-based mental disorder and substance use screening, prevention, and treatment. The research initiative was published in 2020. Eight grants were funded through this initiative (6 NIMH grants and 2 NIDA grants). The NIMH maintains ongoing communication with HRSA to discuss progress and outcomes.
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Improving Genomics/Omics Technical Standards and Molecular Tools for Prebiotic Probiotic Research and Development Working Group
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Research Initiative
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CDC, FDA, OS
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NCCIH, NCI, NHGRI, NIDA, NLM
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The overarching workgroup effort is to enhance research initiatives/resource development as an Interagency Agreement (IAA) workgroup members committed to sustain and accelerate translatability of validation analytics and reference datasets using omics and other multi-omics substitutable [SMART] tools, devices, and HL-7 Fast Healthcare Interoperability Resources (FHIR) technologies to support rapid and efficient interoperability with electronic health records and clinical decision support systems. A second goal is to coordinate and plan trans-NIH and Inter-agency meetings, workshops and initiatives with greater efficiency of Institute and Center Operations (ICO) resources and expertise between agencies. Innovative technologies like HL-7 SMART on FHIR have been demonstrated to enhance health information exchange, affordably and accurately. Novel device monitoring using reference standards including, Food and Drug Administration (FDA) Precision and National Institute of Standards and Technology (NIST) nanofabrication, multi-omics and modeling strategies can be integrated to improve validation and standards biosafety, risk monitoring of adverse drug events, food safety, overuse and resistance to antibiotics, and emerging infection. The intent originated in April 2016 with an Initiative planning meeting that is now ongoing for IAA partnered with the Patient-Centered Outcomes Research Institute (PCORI); other IAA collaboratives in progress.
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Improving Steps in the Development and Assessment of Live Microbiome-Based Products: Fecal Microbiota for Transplantation (FMT) and Live Biotherapeutic Products (LBPs)
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Other
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FDA
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NIAID
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his project seeks to support the development and assessment of live microbiome-base products for the treatment and prevention of infection. Fecal microbiota for transplantation (FMT) utilizes stool from healthy donors to reestablish the gut microbiota of individuals with recurrent C. difficile infection. Whereas live biotherapeutic products (LBPs) are drugs that consist of purified bacteria developed for the prevention, treatment or cure of bacterial vaginosis in women. In the context of this IAA, tools for FMT and LBPs are being developed to prevent disease (or reinfection) after antibiotic treatment by interacting with the human microbiome.
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In Silico Screening for Cancer Targets
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Research Initiative
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FDA
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NCI
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In Silico Screening for Cancer Targets
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In Vitro Assessment of Dermal Hypersensitivity: Using Alternative Methods to Predict Skin Sensitization
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Research Initiative
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FDA
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NIEHS
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The primary goal of these efforts is to assess the utility of non-animal test methods for predicting human skin sensitization hazard in an expanded chemical space
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In Vitro Assessment of Respiratory Hypersensitivity: Using Alternative Methods to Predict Respiratory Sensitization
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Research Initiative
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FDA
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NIEHS
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The primary goal of these efforts is to assess the utility of non-animal test methods for predicting human skin sensitization hazard in an expanded chemical space
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Industrywide exposure assessment study of workers exposed to graphene and other two-dimensional nanomaterials
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Research Initiative
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CDC
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NIEHS
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There have been relatively few studies evaluating the toxicity of 2D nanomaterials and even fewer data are available regarding workplace exposures in the United States. This project will provide real-world exposure data along with important material characteristic information for the interpretation of current and future toxicity and risk assessment studies.
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Influenza Diagnostics Risk Management Meeting (FRMM) Strategy Working Group
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Committee, Work group, Advisory group, or Task Force
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CDC, FDA, ASPR
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NIAID
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Reviewing a draft strategic plan for senior leadership
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Influenza Risk Management Meeting
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Committee, Work group, Advisory group, or Task Force
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CDC, FDA, OS
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NIAID
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The Influenza Risk Management Meetings provide members including the Office of the Assistant Secretary for Preparedness and Response (ASPR) Biomedical Advanced Research and Development Authority (BARDA), the Centers for Disease Control and Prevention (CDC), the Food and Drug Administration (FDA), and the National Institutes of Health (NIH)) with a venue to discuss issues relating to the US Department of Health and Human Services (HHS) response to pandemic influenza. Subjects for discussion include but are not limited to considerations of vaccine and antiviral stockpiles and clinical trial response to influenza outbreaks such as H7N9 and H3N2v.
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