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CMS-NIH Leadership Council
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Committee, Work group, Advisory group, or Task Force
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CMS
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OD/OSP, NCCIH, NCI, NHGRI, NHLBI, NIA, NIDA, NIDDK, NIMHD, OD/IMOD, OD/OER
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Facilitates leadership-level development of mutual priorities between both Department of Health and Human Services (HHS) operating divisions.
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Coccidioidomycosis (Valley Fever): Considerations for Development of Antifungal Drugs
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Meeting/ Workshop
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FDA
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NIAID
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A virtual public workshop sponsored by FDA for coccidioidomycosis (Valley Fever) pertaining to landscape and considerations for developing antifungal drugs. Discussions will focus on the current state and clinical trial design considerations related to coccidioidomycosis.
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Collaborative Acute Toxicity Modeling Suite (CATMoS)
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Committee, Work group, Advisory group, or Task Force
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ATSDR, CDC
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NIEHS, NCATS
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With the increasing number of chemicals to assess for acute oral systemic toxicity potential (LD50) and the lack of in vitro approaches, NICEATM and the ICCVAM Acute Toxicity Workgroup organized an international collaborative project to develop in silico models as alternatives to predict LD50 and bridge data gaps. Participants from 35 groups submitted a total of 139 predictive models built using a dataset of 11,992 chemicals split into training (75%) and evaluation sets (25%). Crowdsourced models were developed for five endpoints: LD50 value, EPA hazard categories, GHS hazard categories, very toxic (LD50 50 mg/kg), and non-toxic (LD50 > 2000 mg/kg). Predictions within the applicability domains of the submitted models were evaluated, then combined into consensus predictions based on a weight-of-evidence approach. The resulting consensus model, forming the Collaborative Acute Toxicity Modeling Suite (CATMoS), leverages the strengths and overcomes the limitations of individual modeling approaches. The consensus predictions are fully reproduceable and performed at least as well as independent replicate in vivo acute oral toxicity assays. The CATMoS consensus model is available via the free and open-source tool OPERA (Open Structure-activity/property Relationship App).
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Collaborative on Healthy Parenting in Primary Care
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Public Education Campaign
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CDC, HRSA, SAMHSA
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NICHD
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The Collaborative on Healthy Parenting in Primary Care recognizes the accumulated evidence of the effectiveness of family-focused prevention programs that promote the physical and behavioral health and emotional well-being of children from before their birth through adolescence. Members of the Collaborative have united around an initiative to support the integration of effective programs that promote healthy parenting into primary care settings in order to achieve optimal health for children.
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Collaborative Use Repurposing Engine ID (CURE ID)
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Research Initiative
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FDA
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NCATS
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CURE ID is an internet-based repository that lets the clinical community report novel uses of existing drugs for difficult-to-treat infectious diseases through a website, a smartphone or other mobile device. The platform enables the crowdsourcing of medical information from health care providers to facilitate the development of new treatments for neglected diseases. CURE ID is a collaboration between the FDA and the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH). FDA and NIH are also collaborating with the World Health Organization and the Infectious Disease Society of America to assess the global utility of the CURE ID.
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Combating Antibiotic Resistant Bacteria (CARB)
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Resource Development
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CDC, FDA
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NLM, NHGRI, NIAID
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The National Action Plan for Combating Antibiotic-resistant Bacteria is a multi-agency initiative to deal with the threat of increasing antibiotic resistance. The National Center for Biotechnology Information (NCBI) has a part in Sub-Objective 2.1.4: Develop and maintain a national sequence database of resistant bacteria.
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Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) Joint Oversight Committee
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Committee, Work group, Advisory group, or Task Force
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BARDA, CDC
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NIAID
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CARB-X is a global non-profit partnership dedicated to accelerating antibacterial research to tackle the global rising threat of drug-resistant bacteria. CarbX is led by Boston University with funding from BARDA, NIAID, and other global funding agencies (Wellcome Trust, Germany’s BMBF, UK GAMRIF and the Gates Foundation). The Joint Oversight Committee oversees operational, financial and strategic activities. NIAID and BARDA staff also monitor progress for projects in the CarbX portfolio, as well as act as reviewers for new proposals to the program.
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Community Engagement Alliance Against COVID-19 Disparities (CEAL) Initiative
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Research Initiative
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AoA
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OD/DPCPSI/ORWH, NICHD
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ORWH supported NIMHD's CEAL initiative by promoting the CEAL webpage via an ORWH blog, and utilizing its promotional toolkit.
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Community Guide Cardiovascular Coordination Team
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Committee, Work group, Advisory group, or Task Force
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CDC
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NHLBI
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The purpose of the workgroup is to assess the feasibility of and conducting an evidence-based review to assess the effectiveness of interventions using community health workers for cardiovascular disease prevention and other relevant topics. The completed reviews will be included in, “The Community Guide sponsored by the Community Preventive Services Task Force”.
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Community Preventive Services Task Force (CPSTF)
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Committee, Work group, Advisory group, or Task Force
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CDC
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ODP, OD/DPCPSI
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The Community Preventive Services Task Force (CPSTF) is an independent, non-federal panel of prevention experts that uses information from rigorously conducted systematic evidence reviews to make public health recommendations for preventive services that are delivered in community settings. These recommendations are intended to inform public health decision-making about policy, practice, and research priorities for community preventive services. Recommendations from the CPSTF are published in The Guide to Community Preventive Services. The Office of Disease Prevention (ODP) represents NIH as an official liaison member and works with the CDC and CPSTF members to ensure that recommendations represent the views, concerns, and needs of the NIH and our constituents. ODP staff also serve on, or recommend NIH scientists to serve on systematic evidence review teams, and help translate CPSTF recommendations and insufficient evidence findings into actions.
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