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Children’s HHS Interagency Leadership on Disasters (CHILD) Working Group
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Committee, Work group, Advisory group, or Task Force
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ACF, CDC, HRSA, OS, SAMHSA
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NICHD, NIAID, NIDA, NIGMS, NIMH
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The U.S. Department of Health and Human Services (HHS) established the Children''s HHS Interagency Leadership on Disasters (CHILD) Working Group in 2010 to identify and comprehensively integrate the activities related to the needs of children across all HHS inter- and intra-governmental disaster planning activities and operations. Co-led by the Administration for Children and Families and the Assistant Secretary for Preparedness and Response, the group then developed recommendations for how HHS can improve the delivery of care to children who are impacted by disasters.
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Chinese Children and Families Cohort Study
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Research Initiative
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CDC
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NCI, OD/DPCPSI/ODS
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The Chinese Children and Families Cohort Study (CFCS) was funded by and conducted in collaboration with the US Centers for Disease Control and Prevention (CDC), Chinese CDC, National Institutes of Health (NIH) Office of Dietary Supplements (ODS), and NCI Division of Cancer Control and Population Sciences (DCCPS), Division of Cancer Epidemiology and Genetics (DCEG), and Center Global Health. CFCS is a pilot study that followed-up a sample of a cohort of women and their offspring enrolled in the Community Intervention Study (1993-1995) of folic acid supplementation to prevent neural tube defects in China.
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Chronic Kidney Disease In Agricultural Communities
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Meeting/ Workshop
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CDC
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NIDDK, NIEHS
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A workshop held June 25-26, 2018 brought together clinicians, basic scientists, epidemiologists, and public health officials to discuss the current gaps in knowledge and to develop a coordinated scientific research agenda leading to a better understanding of the causes and potential treatments of chronic kidney diseases in agricultural communities. In FY19 a meeting report stemming from this workshop was published.
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Circulating Estrogens, Androgens, and Progestogens and Risk of Breast Cancer in the PLCO Cohort
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Research Initiative
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CDC
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NCI
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In a stratified cohort study of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), restricted to postmenopausal women not on menopausal hormone therapy, researchers are using a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay recently developed by the Centers for Disease Control and Prevention (CDC) to assess pre-diagnostic circulating levels of the endogenous steroid hormones believed to be involved in breast cancer etiology. Although it is known that endogenous hormones play a critical role in the etiology of breast cancer, the interrelationships among estrogens, androgens, and progesterone in determining risk are not well understood.
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Clinical and Translational Research Course for PhD Students
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Training Initiative
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FDA
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CC, NCATS, NCI, NHLBI, NIAID, NIDA, NIDCR, NIDDK, NIGMS, NIMH, NINDS
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The Clinical and Translational Research Course for PhD Students is a two-week intensive introductory course for graduate students in the basic biomedical sciences who have at least one year of graduate study. The purpose of the course is to demonstrate and highlight the roles of PhD scientists in clinical and translational research, to provide an overview and examples of how basic science and clinical observations lead to translational research, and to increase awareness and access to PhD role models, research resources, and potential career opportunities at the National Institutes of Health (NIH).
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Clinical Investigator Interagency Working Group for the Development of Antiviral Influenza Therapeutics
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Committee, Work group, Advisory group, or Task Force
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CDC, FDA
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NIAID
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This working group discusses a range of issues relevant to the development of antiviral drugs for the treatment of influenza.
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Clinical Research Using Medicare Data from the Virtual Research Data Center (VRDC)
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Research Initiative
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CMS
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NLM
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The National Library of Medicine (NLM) is working with the Centers for Medicare and Medicaid Services (CMS) and other National Institutes of Health (NIH) institutes and centers (ICs) to demonstrate the value of the CMS Virtual Research Data Center (VRDC) as a source of Big Data.
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Clinical Utilization Plan for Anthrax Medical Countermeasure Use in a Mass Casualty Event (CUPAC) Medical Countermeasures Workgroup
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Committee, Work group, Advisory group, or Task Force
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CDC
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CC
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The National Institutes of Health (NIH) Clinical Center is participating as a member of the Medical Countermeasures Work Group to provide clinical algorithms that will assist clinicians to evaluate, triage, diagnose and treat large numbers of patients presenting with symptoms of anthrax. It will also provide a clinical prioritization schema for the use of medical countermeasures specific to anthrax and outline unique critical care issues that may require special consideration.
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Clinical Vocabulary and Standards Development for Meaningful Use of Electronic Medical Records
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Committee, Work group, Advisory group, or Task Force
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AHRQ, CDC, CMS, OS
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NLM
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The National Library of Medicine (NLM) is collaborating with the Office of the Secretary OS and the Department of Health and Human Services (HHS) Office of the National Coordinator for Health Information Technology (ONC) on developing and disseminating regulatory language related to health information technology, meaningful use, and standards and certification criteria related to electronic health records and messaging. The collaboration includes serving as members of the Content Standards Workgroup, and Semantic Standards Workgroup of the Health IT (HIT) Standards Committee. The HIT Standards Committee is a Federal advisory committee that was created by the Health Information Technology for Economic and Clinical Health (HITECH) Act to provide input to HHS on the policies and technologies needed to improve health and care.
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ClinicalTrials.gov
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Resource Development
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FDA
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NLM, CC, NCATS, NCCIH, NCI, NCMHD, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, OD/DPCPSI/OBSSR, OD/OER, OD/OLPA, OD/OSP
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ClinicalTrials.gov is a National Library of Medicine (NLM) operated database containing summary protocol and results information from publicly and privately funded clinical research studies. As of September 2019, the database included summary protocol information on nearly 318,000 clinical studies conducted in over 200 countries, with approximately 40,000 of these records displaying summary results. NLM originally collaborated with the Food and Drug Administration (FDA) on implementing Section 113 of the Food and Drug Administration Modernization Act of 1997. It subsequently collaborated with FDA, the Department of Health and Human Services (HHS) Office of the General Counsel (OGC), and the National Institutes of Health (NIH) Office of the Director (OD) to implement the statutory requirements of Section 801 of the Food and Drug Administration Amendments Act of 2007 through rulemaking. Regulations (42 CFR Part 11) were promulgated in September 2016. NLM continues its collaboration with FDA, OD/OSP, OGC, and other parts of NIH to implement the requirements under 42 CFR Part 11, provide educational information, conduct outreach activities, and develop compliance workflows and reporting tools. NLM is also continuing its collaborating with NIH OD and other parts of NIH to implement the 2016 NIH Policy on the Dissemination of NIH-funded Clinical Trial Information and other NIH policies (e.g., reporting results of valid analyses by sex/gender and race/ethnicity for NIH-funded trials to ClinicalTrials.gov as required by the 21st Century Cures Act). Additionally, NLM worked closely with OD/OSP to assist OHRP in implementing the Posting of Clinical Trial Consent Form provision of the revised Common Rule at 45 CFR 46.116(h). NLM has also been working with OD/OBSSR to develop resource materials specific to researchers in the field of behavioral and social science to better support submission of their research to ClinicalTrials.gov. Finally, NLM has been collaborating with OD/OSP, OER, OLPA, and OCPL on analyzing approaches for reporting NIH-funded basic experimental studies with humans.
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