Computational Modeling of Hormone Homeostasis Initiative

Sex hormones interact with many tissues and body systems outside of just reproductive tissues, including the lungs, bones, and immune system. Changes in hormone homeostasis, such as fluctuations that occur during puberty, the menstrual cycle, pregnancy, and menopause, can trigger systemic responses and long-term changes to the body. Men and women often experience different reactions to drug therapy, including varying outcomes to dosing, treatment response, and drug toxicity. Although the molecular features driving these differences are not fully understood, it is thought that differences in hormone homeostasis between sexes may affect therapeutic responses to some medications.  

To better understand these differences, this initiative aims to stimulate the development of novel human-based, data-driven models tailored to a man or a woman’s complex male/female physiology through advanced computational techniques. These techniques may include digital twins, interactive machine learning, multi-scale models, artificial intelligence (AI)-enhanced multi-scale models, and more. This initiative will bring new approaches to hormone homeostasis research by enabling the research community to identify new opportunities and priorities for technology-led, innovative, high-impact research that transforms women’s health. 

Interested in applying? Check out the technical assistance webinar.