The NIH RADx®-Underserved Populations (RADx®-UP) initiative will hold its annual Scientific Meeting virtually on May 3, 2023, from 1 to 5 p.m. E.T. Scheduled presentations include an update about the Cherokee Nation Community-Driven Program for Testing and Contact Tracing (Cherokee PROTECT) survey, and COVID-19 monitoring methods, building capacity, and Indigenous data sovereignty with a Northern Plains Tribe.