Division of Construction and Instruments

The S10 Instrumentation Programs

ORIP's S10 Instrumentation Grant Programs consist of two components: the Shared Instrumentation Grants (SIG) and High-End Instrumentation (HEI) Grants. These programs support purchases of state-of-the-art commercially available instruments to enhance research of NIH–funded investigators. Instruments that are awarded are typically too expensive to be obtained by an individual investigator with a research project grant. Every instrument awarded by an S10 grant is used on a shared basis, which makes the programs cost-efficient and beneficial to thousands of investigators in hundreds of institutions nationwide.

S10 awards are made to domestic public and private institutions of higher education, and non-profit domestic institutions such as hospitals, health professional schools, and research organizations. To be eligible for an S10 award, an institution must identify three or more Principal Investigators with active NIH research awards who demonstrate substantial need for the requested instrument.

Awards are issued for one year, and matching funds are not required. However, ORIP expects institutions that compete for S10 awards to provide an appropriate level of support for associated infrastructure, such as space to house the instrument, technical personnel, and post-award service contracts for instrument maintenance and operation.

Types of instruments supported by S10 funding include, but are not limited to: X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers.

ORIP manages the S10 programs by issuing two Funding Opportunity Announcements (FOA) with one annual receipt date:

Information about general program requirements can be found in the most recent announcements. Pending available funds, ORIP expects to publish new FOAs in late Winter/early Spring. ORIP encourages applicants to familiarize themselves with these documents before finalizing their applications so that submitted documents follow the up-to-date guidance on the application content and format.

Frequently Asked Questions

ORIP has a series of Frequently Asked Questions and Answers (Q&As) to describe some of the NIH policies and practices relevant to S10 applications and S10 grants. Click here to view Q&As.

Previous Awards

  • In FY 2016, the SIG program provided 82 awards to biomedical research institutions in 25 states totaling $36,335,382. To see a list of these awards click on the link FY 2007 - 2016 SIG Awards.
  • In FY 2016, the HEI program provided 23 awards to research institutions in 13 states totaling $31,575,287. To see a list of these awards click on the link FY 2006 - 2016 HEI Awards.

How to Apply

S10 applications are submitted to NIH electronically through Grants.gov Exit Disclaimer, using the SF 424 Research and Related forms Exit Disclaimer. The application receipt date is once a year, usually in March.

For more information about NIH Grants and Funding follow thelink . In addition, NIH’s Center for Scientific Review provides many resources for applicants and reviewers.

Information for Grantees


Contact Information

SIG Program Contact:

Alena Horska, PhD 
Phone: 301-435-0815

HEI Program Contact:

Abraham Levy, PhD
Phone: 301-435-0777

ORIP Office Address:

Division of Construction and Instruments (DCI)
Office of Research Infrastructure Programs (ORIP)
Division of Program Coordination, Planning and Strategic Initiatives (DPCPSI)
Office of the Director (OD)
National Institutes of Health (NIH)
6701 Democracy Blvd, Room 901
Bethesda, MD 20892

Phone: 301-435-0772
Fax: 301-480-3659

This page last reviewed on April 4, 2017