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(08) Genomics
Topics in the table below that are marked with an asterisk (*) have been designated as the Institute, Center or Office’s highest priority; however, applicants may apply to any of the topics.
| Challenge Topic ID |
Specific Challenge Topic |
Contact |
| 08-OD-101 |
Computational approaches for epigenomic analysis. Technologies such as ultra-high-throughput sequencing allow one to perform epigenomic analyses that were previously impossible. However one of the major remaining challenges is the lack of effective tools for the analysis and integration of epigenomic data. The development of computational or statistical tools to analyze epigenomic data and integrate it with other data types (multiple epigenetic marks, gene expression data, DNA sequence, comparison to diseased cell types etc) would allow epigeneticists to overcome this challenge and make it significantly easier for researchers to investigate the epigenomic basis of disease states. |
Dr. Joni Rutter (NIDA)
301-435-0298
jrutter@mail.nih.gov |
| 08-OD-102 |
Integrated Analysis of Epigenetic and Genetics Alterations in Environment-Induced Human Disease. Both genetic and epigenetic approaches are yielding exciting insights into mechanisms of environmental disease pathogenesis and ultimately suggesting novel therapeutic targets and strategies. The integration of epigenetic and genetic data will be necessary to understand gene-environment interactions in complex human diseases. Applicants may consider using existing human biological samples in existing cohorts. |
Dr. Kim McAllister (NIEHS)
919-541-4528
mcallis2@mail.nih.gov
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