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High End Instrumentation

ORIP's High-End Instrumentation (HEI) grant program supports the purchase of a single major piece of research equipment that costs between $600,000 to $2.0 million for biomedical research only. Instruments in this price range include, but are not limited to, structural and functional imaging systems, macromolecular NMR spectrometers, high-resolution mass spectrometers, electron microscopes, and supercomputers.


In FY 2015, the HEI program provided 19 awards to research institutions in 13 states totalling $26,162,569.

Awards FY2006 - 2015


Rapid technological development has led to the production of a new generation of instruments. These high-sensitivity, high-resolution instruments can accelerate and enhance the rate at which researchers can acquire, analyze, display, and understand data. To assist NIH-supported investigators to keep at the forefront of modern biology and medicine research, in 2002 NIH began the HEI grant program. HEI awards, which are for one year and are not renewable, provide support for up to a maximum of $2.0 million in direct costs for a single major piece of research equipment. The floor is set at $600,000. The HEI grant program complements the Shared Instrumentation Grant program.

Eligibility Requirements
  • Institutions: HEI grants are awarded to domestic public and non-profit health professional schools, other academic institutions, hospitals, health departments, and research organizations. It is anticipated that only a few grants will be awarded in a given technological area.
  • Applicants: The instrument must be shared by a minimum of three principal investigators on NIH peer-reviewed research grants awarded through the following NIH funding mechanisms: R01, U01, P01, P50, R37, DP1 and DP2. Once this eligibility requirement has been met, additional users with other types of active NIH research grants mechanisms (such as but not limited to R00, R03, R21, P30, and P41) can be added as major or minor users. NIH training grants and contracts are not eligible. Applicants must demonstrate a clear need for the requested instrumentation, ensuring that at least 75 percent of the total usage time will be for projects supported by NIH research grants.

Awards are for one year, and matching funds are not required. However, ORIP expects institutions that compete for HEI awards to provide an appropriate level of support for associated infrastructure, such as building alterations or renovations, technical personnel, and post-award service contracts for instrument maintenance and operation.

How to Apply

A Program Announcement for the HEI program is published in the NIH Guide for Grants and Contracts ( with a receipt date in May. This announcement includes information on the research objectives, eligibility criteria, application and review procedures, award criteria, and contact information. HEI applications are submitted to NIH electronically through  Exit Disclaimer using the SF 424 Research and Related forms.

Forms for Grantees

Contact Information

For further information, contact:

Abraham Levy, Ph.D.
Director, SIG and High End Programs
Division of Construction and Instruments
Telephone: 301-435-0777
Fax: 301-480-3659

Mailing address: 

Office of Research Infrastructure Programs
Division of Program Coordination, Planning, and Strategic Initiatives
Office of the Director
National Institutes of Health
One Democracy Plaza, Room 966

6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)



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