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Division of Comparative Medicine

ORIP's Division of Comparative Medicine helps meet the needs of biomedical researchers for high-quality, disease-free animals and specialized animal research facilities. The Division supports both individuals and research organizations. 
See the latest news, policies, education and training materials, and information about animals in research on the NIH Medical Research with Animals website.

 

 

 

 

 

 

 

 

 

 

 

 

 

Selected Supported Scientific Advances:

Akbari OS, Bellen HJ, Bier E, Bullock SL, Burt A, Church GM, Cook KR, Duchek P, Edwards OR, Esvelt KM, Gantz VM, Golic KG, Gratz SJ, Harrison MM, Hayes KR, James AA, Kaufman TC, Knoblich J, Malik HS, Matthews KA, O'Connor-Giles KM, Parks AL, Perrimon N, Port F, Russell S, Ueda R, Wildonger J.
BIOSAFETY. Safeguarding gene drive experiments in the laboratory.
Science. 2015; 349(6251):927-9. PMC4692367

 

Nikolakakis K, Monfils K, Moriano-Gutierrez S, Brennan CA, Ruby EG.
Characterization of the Vibrio fischeri Fatty Acid Chemoreceptors, VfcB and VfcB2.
Appl Environ Microbiol. 2015; 82(2):696-704. PMC4711111

 

Pereira L, Kratsios P, Serrano-Saiz E, Sheftel H, Mayo AE, Hall DH, White JG, LeBoeuf B, Garcia LR, Alon U, Hobert O.
A cellular and regulatory map of the cholinergic nervous system of C. elegans.
Elife. 2015; 4. pii: e12432. PMC4769160

 

Christensen RP, Bokinsky A, Santella A, Wu Y, Marquina-Solis J, Guo M, Kovacevic I, Kumar A, Winter PW, Tashakkori N, McCreedy E, Liu H, McAuliffe M, Mohler W, Colón-Ramos DA, Bao Z, Shroff H.
Untwisting the Caenorhabditis elegans embryo.
Elife. 2015; 4. pii: e10070. PMC4764590

 

Schartl M, Shen Y, Maurus K, Walter R, Tomlinson C, Wilson RK, Postlethwait J, Warren WC.
Whole Body Melanoma Transcriptome Response in Medaka.
PLoS One. 2015; 10(12):e0143057. PMC4699850

 

Cole SW, Capitanio JP, Chun K, Arevalo JM, Ma J, Cacioppo JT.
Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation.
Proc Natl Acad Sci U S A. 2015; 112(49):15142-7. PMC4679065

 

Karvinen S, Waller K, Silvennoinen M, Koch LG, Britton SL, Kaprio J, Kainulainen H, Kujala UM.
Physical activity in adulthood: genes and mortality.
Sci Rep. 2015; 5:18259. PMC4678877

 

Nichols AL, Meelkop E, Linton C, Giordano-Santini R, Sullivan RK, Donato A, Nolan C, Hall DH, Xue D, Neumann B, Hilliard MA.
The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.
Cell Rep. 2016; 14(7):1673-83. PMC4821572

 

Miller DE, Cook KR, Yeganeh Kazemi N, Smith CB, Cockrell AJ, Hawley RS, Bergman CM.
Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster.
Proc Natl Acad Sci U S A. 2016; 113(10):E1352-61. PMC4790991

 

Bertolino E, Reinitz J, Manu.
The analysis of novel distal Cebpa enhancers and silencers using a transcriptional model reveals the complex regulatory logic of hematopoietic lineage specification.
Dev Biol. 2016; 413(1):128-44. PubMed - in process

 

Lou Z, Reinitz J.
Parallel Simulated Annealing Using an Adaptive Resampling Interval.
Parallel Comput. 2016; 53:23-31. PMC4770898

 

Bongrand C, Koch EJ, Moriano-Gutierrez S, Cordero OX, McFall-Ngai M, Polz MF, Ruby EG.
A genomic comparison of 13 symbiotic Vibrio fischeri isolates from the perspective of their host source and colonization behavior.
ISME J. 2016. doi: 10.1038/ismej.2016.69. PubMed - as supplied by publisher

 

Aschtgen MS, Wetzel K, Goldman W, McFall-Ngai M, Ruby E.
Vibrio fischeri-derived outer membrane vesicles trigger host development.
Cell Microbiol. 2016; 18(4):488-99. PMC4803540

 

Schwartzman JA, Ruby EG.
A conserved chemical dialog of mutualism: lessons from squid and vibrio.
Microbes Infect. 2016; 18(1):1-10. PMC4715918

 

Braasch I, Gehrke AR, Smith JJ, Kawasaki K, Manousaki T, Pasquier J, Amores A, Desvignes T, Batzel P, Catchen J, Berlin AM, Campbell MS, Barrell D, Martin KJ, Mulley JF, Ravi V, Lee AP, Nakamura T, Chalopin D, Fan S, Wcisel D, Cañestro C, Sydes J, Beaudry FE, Sun Y, Hertel J, Beam MJ, Fasold M, Ishiyama M, Johnson J, Kehr S, Lara M, Letaw JH, Litman GW, Litman RT, Mikami M, Ota T, Saha NR, Williams L, Stadler PF, Wang H, Taylor JS, Fontenot Q, Ferrara A, Searle SM, Aken B, Yandell M, Schneider I, Yoder JA, Volff JN, Meyer A, Amemiya CT, Venkatesh B, Holland PW, Guiguen Y, Bobe J, Shubin NH, Di Palma F, Alföldi J, Lindblad-Toh K, Postlethwait JH.
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
Nat Genet. 2016; 48(4):427-37. PMC4817229

 

Shen Y, Chalopin D, Garcia T, Boswell M, Boswell W, Shiryev SA, Agarwala R, Volff JN, Postlethwait JH, Schartl M, Minx P, Warren WC, Walter RB.
X. couchianus and X. hellerii genome models provide genomic variation insight among Xiphophorus species.
BMC Genomics. 2016; 17:37. PMC4705583

 

Ratzan W, Falco R, Salanga C, Salanga M, Horb ME.
Generation of a Xenopus laevis F1 albino J strain by genome editing and oocyte host-transfer.
Dev Biol. 2016; pii: S0012-1606(15)30350-X.

 

Tandon P, Conlon F, Furlow JD, Horb ME.
Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling.
Dev Biol. 2016; pii: S0012-1606(16)30063-X.

 

Lei S, Ryu J, Wen K, Twitchell E, Bui T, Ramesh A, Weiss M, Li G, Samuel H, Clark-Deener S, Jiang X, Lee K, Yuan L.
Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency.
Sci Rep. 2016; 6:25222. PMC4846862

 

Handley SA, Desai C, Zhao G, Droit L, Monaco CL, Schroeder AC, Nkolola JP, Norman ME, Miller AD, Wang D, Barouch DH, Virgin HW.
SIV Infection-Mediated Changes in Gastrointestinal Bacterial Microbiome and Virome Are Associated with Immunodeficiency and Prevented by Vaccination.
Cell Host Microbe. 2016; 19(3):323-35. PMC4802495

 

Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL.
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.
Nat Med. 2016; 22(4):362-8.

 

Shaheen R, Anazi S, Ben-Omran T, Seidahmed MZ, Caddle LB, Palmer K, Ali R, Alshidi T, Hagos S, Goodwin L, Hashem M, Wakil SM, Abouelhoda M, Colak D, Murray SA, Alkuraya FS.
Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice.
Am J Hum Genet. 2016; 98(4):643-52. PMC4833216

 

West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC.
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
PLoS Genet. 2016; 12(2):e1005691. PMC4739719

 

Au SH, Storey BD, Moore JC, Tang Q, Chen YL, Javaid S, Sarioglu AF, Sullivan R, Madden MW, O'Keefe R, Haber DA, Maheswaran S, Langenau DM, Stott SL, Toner M.
Clusters of circulating tumor cells traverse capillary-sized vessels.
Proc Natl Acad Sci U S A. 2016; 113(18):4947-52.

 

Tang Q, Moore JC, Ignatius MS, Tenente IM, Hayes MN, Garcia EG, Torres Yordán N, Bourque C, He S, Blackburn JS, Look AT, Houvras Y, Langenau DM.
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.
Nat Commun. 2016; 7:10358. PMC4735845

 

Araínga M, Su H, Poluektova LY, Gorantla S, Gendelman HE.
HIV-1 cellular and tissue replication patterns in infected humanized mice.
Sci Rep. 2016;6:23513. PMC4800734

 

Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CG, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF.
Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism.
Immunity. 2016;44(3):634-46. PMC4845739

 

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