- 3D Imaging Informatics for High Resolution Electron Microscopy and Advanced Imaging Tools for Cancer Research
- Addictions Institutional Review Board (IRB)
- Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Executive Committee
- Antibody Interest Group (ABIG)
- Asthma Phenotypes Task Force
- Autoimmune Disease Coordinating Committee (ADCC)
- Barriers to Clinical Research
- Basic Behavioral and Social Science Opportunity Network (OppNet)
- Best Pharmaceuticals for Children Act (BPCA) Dermatology Working Group
- Best Pharmaceuticals for Children Act (BPCA) Oncology Working Group
- Best Pharmaceuticals for Children Act (BPCA) Rheumatology Working Group
- Blood Xenotropic Murine Leukemia Virus-Related Virus Scientific Research Working Group
- Bridging Interventional Development Gaps (BrIDGs) Committee
- Cell Cycle Interest Group
- Centers for AIDS Research (CFAR) Steering Committee
- Cervical Cancer Prevention Working Group
- Child Abuse and Neglect Working Group
- Chromatin and Chromosomes Interest Group
- Clinical and Translational Science Awards (CTSA) Strategic Goal IV Committee
- Clinical Trial Working Group Co-morbidity Project
- Common Data Elements (CDEs) Working Group
- Cytokine Interest Group
- Diabetes Mellitus Interagency Coordinating Committee (DMICC)
- Emerging Infectious Diseases and the Human Animal Interface, Identifying Common Ground Among Federal Agencies
- eRA Technical User Group (eTUG)
- Extramural-Intramural Collaborations Workgroup
- Eyegene Common Data Elements and Vocabulary Standards
- Federal Working Group on Bone Diseases
- Federal Working Group on Dietary Supplements (FWGoDS)
- Geroscience Interest Group
- Health Literacy Work Group
- Healthy People 2020 – Sleep Health Working Group
- Human Subjects Research Advisory Committee (HSRAC)
- IC Animal Events Response Committee
- ICARE: Interagency Collaborative to Advance Research in Epilepsy
- Immunology Interest Group (IIG)
- In vitro Assessments for Antimicrobial Activity
- Inclusion Tracking System Re-engineering Project (Business Process Modeling Phase)
- Inter-Institute Imaging Group (I3G)
- Interagency Breast Cancer and Environmental Research Coordinating Committee (IBCERCC)
- Interagency Modeling and Analysis Group (IMAG)
- Intramural Glycobiology Scientific Interest Group Steering Committee
- Kidney Interagency Coordinating Committee (KICC)
- Knowledge Management and Health: Translational Applications for Semantic Abstraction Technologies
- Knowledge Management Tool-kit to Facilitate Research Portfolio Analysis
- Light Microscopy Interest Group
- Lupus Federal Working Group (LFWG)
- Managing Conflict of Interest in the Initial Peer Review of NIH Grants and Cooperative Agreements Committee
- Martin Delaney Collaboratory Program Management Team
- mHealth Research Inter-Institute Interest Group (IIG)
- Multi-Agency Tissue Engineering Science (MATES) Interagency Working Group (IWG)
- Muscular Dystrophy Coordinating Committee
- Nanomedicine-Nanotech Interest Group
- National Advisory Board on Medical Rehabilitation Research
- National Cancer Institute (NCI) Alliance of Glycobiologists
- National Children's Study Program Chair Committee
- National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Prevention Guidelines Expert Panels and Work Groups
- Neurobiobank Workgroup
- NICHD/FDA Newborn Drug Development Planning Committee
- NIH Human Subjects Protection Liaison Committee
- NIH Adherence Research Network
- NIH and National Aeronautics and Space Administration (NASA) Collaboration on Space-Related Health Research
- NIH Autism Coordinating Committee (NIH/ACC)
- NIH Biomedical Information Science and Technology Initiative Consortium
- NIH Blueprint for Neuroscience Research
- NIH Clinical Advisors to the Genetic Testing Registry
- NIH Cognitive and Emotional Health Project (CEHP) Steering Committee
- NIH Comparative Effectiveness Research (CER) Coordinating Committee
- NIH End-of-Life/Palliative Care Scientific Interest Group
- NIH Financial Conflict of Interest (FCOI) Committee
- NIH Genome-Wide Association Studies (GWAS) Senior Oversight Committee
- NIH Genome-Wide Association Studies (GWAS) Technical Standards and Data Submission Steering Committee (TSDS)
- NIH Institute and Center International Representatives Forum
- NIH International Tuberculosis (TB) Working Group
- NIH Lesbian, Gay, Bisexual, Transgender, and Intersex (LGBTI) Research Coordinating Committee
- NIH Neuroprosthesis Group
- NIH Obesity Research Task Force
- NIH Pain Consortium
- NIH Proteomics Interest Group (ProtIG)
- NIH Rehabilitation Coordinating Committee
- NIH Robotics Working Group
- NIH Scientific Interest Group
- NIH Steering Committee on Trans Institute Angiogenesis Research Program (TARP)
- NIH Stem Cell Task Force and Stem Cell Implementation Committee
- NIH Working Group on Down Syndrome
- NIH Working Group on Emergency Medicine
- NIH's Strategic Communications Planning Project
- NIH- South Africa Medical Research Council (MRC) Program
- NIH/FDA Leadership Council’s Workgroup on Preclinical Toxicology
- NINDS Common Data Elements and Vocabulary Standards
- Nutrition Coordinating Committee (NCC)
- Participant Protection and Data Management Steering Committee
- Pediatric neuroimaging Workgroup
- Pharmacogenetics Research Network
- PhenX Project – Genome-Wide Association Studies
- Pigment Cell and Melanoma Research Interest Group
- Placebo Working Group
- Post-traumatic Stress Disorder (PTSD)/Traumatic Brain Injury (TBI) Workgroup
- Prevention Research Coordinating Committee (PRCC)
- Public Private Partnerships
- Quantitative Systems Pharmacology Working Group
- Research Prioritization Task Force of National Action Alliance for Suicide Prevention (NAASP)
- Semantic Portfolio Analyst
- Smoking and Schizophrenia Working Group
- Special Populations Research Forum
- Steering Committee for Standards of Research on Chronic Low Back Pain (cLBP)
- Synchrotron Program Officers Group (SPOG)
- Systems Biology Scientific Interest Group (SysBioSIG)
- TGF-beta Superfamily Interest Group
- The Blueprint Neurotherapeutics Network (BPN)
- The Breast Cancer & the Environment Research Program (BCERP)
- The NIH Bone Marrow Stromal Cell Transplantation Center (BMSCTC)
- Therapeutics Discovery Project (TDP) Team
- Tobacco and Nicotine Research Interest Group (TANRIG)
- Trans-NIH Advisory Group (TAG), Therapeutics for Rare & Neglected Diseases (TRND) Program
- Trans-NIH Bioethics Committee
- Trans-NIH BioMedical Informatics Coordinating Committee
- Trans-NIH Communication Group on Genetics and Common Disease
- Trans-NIH Coordinating Committee for Lymphatic Research
- Trans-NIH Coordinating Committee on HIV and Aging
- Trans-NIH Coordinating Committee on Research on Women's Health (CCRWH)
- Trans-NIH Data Sharing Policy Working Group
- Trans-NIH Diabetes Complications Working Group
- Trans-NIH Dissemination and Implementation Research Workgroup
- Trans-NIH Endocrine Group
- Trans-NIH Fragile X Research Group
- Trans-NIH Gene Therapy Committee
- Trans-NIH Genetics/Genomics Coordinating Committee for HIV/AIDS Research
- Trans-NIH Global Health Research Working Group
- Trans-NIH Hepatitis C Virus (HCV) Working Group
- Trans-NIH Liver Cancer Working Group
- Trans-NIH Minority Health and Health Disparities Strategic Plan
- Trans-NIH Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Research Working Group
- Trans-NIH Nanotechnology Task Force
- Trans-NIH Neurofibromatosis Working Group
- Trans-NIH Overlapping Chronic Pain Conditions Working Group
- Trans-NIH Plan for HIV-Related Research Coordinating Committees
- Trans-NIH Proteostasis Scientific Interest Group (SIG)
- Trans-NIH Rare Diseases Working Group
- Trans-NIH Sarcoidosis Working Group
- Trans-NIH Sequencing Inventory Working Group
- Trans-NIH Sickle Cell Group
- Trans-NIH Sleep Research Coordinating Committee
- Trans-NIH Social Media Collaborative
- Trans-NIH Tuberous Sclerosis Complex (TSC) Working Group
- Trans-NIH Web Material Transfer Agreement Project
- Trans-NIH Women’s Health Research Group
- Trans-NIH Working Group on Climate Change and Health
- Trans-NIH Xenopus Working Group
- Trans-NIH Zebrafish Coordinating Committee
- Translational Research Interest Group
- U.S.-China Program for Biomedical Collaborative Research Working Group
- U.S.-India Joint Working Group on Prevention of Sexually Transmitted Diseases (STDs) and HIV/AIDS
- U.S.-Russia Collaboration on Research Related to HIV/AIDS
- Undiagnosed Diseases Program
- United States Critical Illness and Injury Trials Group (USCIIT)
- Vaccines for Cancer Prevention Working Group
- Wireless Medical Technologies Working Group
- Wnt Working Group
- Working Group on Eukaryotic Pathogens and Disease Vectors Target Selection
- Working Group on the NIH Project to Establish Biomedical Beamlines at NSLS-II
3D Imaging Informatics for High Resolution Electron Microscopy and Advanced Imaging Tools for Cancer Research
The National Library of Medicine (NLM) continued its collaboration with the National Cancer Institute''s (NCI) Center for Cancer Research, Laboratory for Cell Biology on 3D Imaging Informatics for High Resolution Electron Microscopy. The group created software tools and visualization using nano-scale modalities (Transmission Electron Tomography and Ion Ablation - Scanning Electron Microscopy); refined image analysis software based on Insight Toolkit for HIV virion detection; developed software for NCI’s new microscope data; developed graphics processing unit-based image reconstruction software for 3D protein spikes from the surface of HIV virions; managed segmentation tasks for murine myocyte stem-cell differentiation; and collected data from Boundary Marking Tool for the Cervical Biopsy Study at 5 sites in the United States (University of Oklahoma), Nigeria, Costa Rica, Netherlands and Spain. NCI and the American Society for Colposcopy and Cervical Pathology used NLM''s Teaching Tool to help train medical students and practitioners to detect cervical cancer.
Addictions Institutional Review Board (IRB)
This Board was established to review, approve, and monitor biomedical and behavioral research involving humans in the area of alcohol and drug addictions, mainly at the Intramural Research Programs of the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The goal is to protect human subjects from physical or psychological harm. The IRB is governed by Title 45 Code of Federal Regulations Part 46, regulated by the Office for Human Research Protections of the Department of Health and Human Services, and overseen by the NIH Office of Human Subjects Research Protection.
Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Executive Committee
ATN Network governance and coordination is provided by an Executive Committee, comprised of the Principal Investigator and Project Director of the ATN Coordinating Center, the Vice Chair(s) for any subgroup of the Adolescent Medicine Leadership Group, the Principal Investigator and Project Director of the Data and Operations Center, the Chair and Vice Chair of the Adolescent Medicine Trials Units Principal Investigators, and the National Institute of Child Health and Human Development (NICHD) Project Scientist. Other NIH scientists, Chairs and Vice Chairs of ancillary clinical and community coordinator groups, and the staff person of the Community Advisory Board serve as non-voting ad hoc members. The Executive Committee enforces the established policies and procedures of the ATN.
Antibody Interest Group (ABIG)
The NIH ABIG aims to promote information exchange and interaction among NIH scientists who work on various aspects of antibody engineering and therapy. The success of antibody therapy requires a deep understanding of biological systems in relation to molecular and cell biology, immunology, biochemistry, and microbiology as well as diseases such as cancer, autoimmunity, and infectious diseases. Interest in antibody therapy crosses traditional biomedical disciplinary boundaries. ABIG provides an open forum for multidisciplinary discussion among colleagues who otherwise may have limited interaction. The principal ABIG activities are monthly meetings on current topics as well as an annual symposium on the NIH campus. The monthly ABIG meetings are open to everyone interested. These meetings are devoted to research seminars on numerous aspects of antibody engineering and therapy that will be presented by both NIH scientists and outside speakers.
Asthma Phenotypes Task Force
This task force develops definitions for specific asthma phenotypes and promotes a phenotype checklist for use in describing research study populations. Presentations at national meetings have been given over the last two years, and a manuscript for publication is in development.
Autoimmune Disease Coordinating Committee (ADCC)
The purpose of the ADCC is to provide a forum for the coordination of research efforts in autoimmunity and autoimmune diseases among various stakeholders including the NIH Institutes, other federal agencies such as the Food and Drug Administration and the Centers for Disease Control and Prevention, and private organizations with an interest in autoimmune diseases. The ADCC meets twice yearly to discuss a broad range of basic, preclinical and clinical endeavors.
Barriers to Clinical Research
The NIH Intramural Working Group (IWG) launched this initiative to identify and reduce barriers to efficient and effective NIH-sponsored clinical research. The Medical Executive Committee was charged by the IWG with executing this initiative; its initial focus has been to address barriers to clinical research in the NIH intramural setting. The Medical Executive Committee conducted a study on the barriers to clinical research and produced a draft report that was submitted to the IWG. Parts of the report findings were taken on by the NIH. For example, the Intramural Clinical Research Steering Committee (ICRSC) was formed, and a new position was created to head that committee, the NIH Deputy Director for Intramural Clinical Research. In addition, NIAID took the draft report’s findings to create a protocol-developing service for its investigators.
Basic Behavioral and Social Science Opportunity Network (OppNet)
Launched in late 2009 and facilitated by the Office of Behavioral and Social Sciences Research (OBSSR), OppNet is a trans-NIH initiative with the mission of pursuing opportunities for strengthening basic behavioral and social science research at NIH, while innovating beyond existing investments. Twenty-four Institutes and Centers and four Program Offices within the NIH integrate existing NIH efforts, target research challenges best met collectively, and collaborate on new research initiatives in complementary scientific areas. Major focal scientific areas include the self-regulation of behavior, the influence of the social environment on basic behavioral mechanisms, reliable and valid measures of psychosocial variables associated with sleep and the social environment, basic research on decision-making, and reliable and valid measures of psychosocial and physiological processes associated with stress.
Best Pharmaceuticals for Children Act (BPCA) Dermatology Working Group
Testing medications in children presents considerable scientific, clinical, ethical, technical, and logistical challenges. As a result, the majority of medications given to children today are used without adequate understanding of appropriate dose, safety, or efficacy. The BPCA established a program at NIH for pediatric medication development. BPCA activities include identifying and prioritizing medications needing study; developing study requests; and conducting studies on priority medications after manufacturers decline to do so. The BPCA Priority List includes key therapeutic needs in the treatment of children and adolescents, organized by Therapeutic Area, which can be a group of conditions, a population subgroup, or a setting of care. Each year, a few Therapeutic Areas are selected for discussion. Working groups meet to identify the gaps in knowledge and set priorities. One of these working groups is organized around dermatology.
Best Pharmaceuticals for Children Act (BPCA) Oncology Working Group
Testing medications in children presents considerable scientific, clinical, ethical, technical, and logistical challenges. As a result, the majority of medications given to children today are used without adequate understanding of appropriate dose, safety, or efficacy. The BPCA established a program at NIH for pediatric medication development. BPCA activities include identifying and prioritizing medications needing study; developing study requests; and conducting studies on priority medications after manufacturers decline to do so. The BPCA Priority List includes key therapeutic needs in the treatment of children and adolescents, organized by Therapeutic Area, which can be a group of conditions, a population subgroup, or a setting of care. Each year, a few Therapeutic Areas are selected for discussion. Working groups meet to identify the gaps in knowledge and set priorities. One of these working groups is organized around oncology.
Testing medications in children presents considerable scientific, clinical, ethical, technical, and logistical challenges. As a result, the majority of medications given to children today are used without adequate understanding of appropriate dose, safety, or efficacy. The BPCA established a program at NIH for pediatric medication development. BPCA activities include identifying and prioritizing medications needing study; developing study requests; and conducting studies on priority medications after manufacturers decline to do so. The BPCA Priority List includes key therapeutic needs in the treatment of children and adolescents, organized by Therapeutic Area, which can be a group of conditions, a population subgroup, or a setting of care. Each year, a few Therapeutic Areas are selected for discussion. Working groups meet to identify the gaps in knowledge and set priorities. One of these working groups is organized around rheumatology.
Blood Xenotropic Murine Leukemia Virus-Related Virus Scientific Research Working Group
Recent studies indicate that xenotropic murine leukemia virus (MLV) related virus (XMRV), a human gammaretrovirus, and other related viruses, may be associated with both prostate cancer and myalgic encephalomyelitis/chronic fatigue syndrome. The Department of Health and Human Services established the working group to explore the prevalence of XMRV in the donor population, the transmissibility of XMRV by blood transfusion, and any possible pathologic consequences for the infected recipient, if it proves to be transmissible.
Bridging Interventional Development Gaps (BrIDGs) Committee
BrIDGs makes available, on a competitive basis, certain critical resources needed for the development of new therapeutic agents. Investigators do not receive grant funds through this program. Instead, successful applicants receive access to NIH contractors who conduct preclinical studies at no cost to the investigator. In general, synthesis, formulation, pharmacokinetic and toxicology services in support of investigator-held investigational new drug applications to the U.S. Food and Drug Administration are available.
Cell Cycle Interest Group
The Cell Cycle Interest Group is composed of researchers at NIH and in the local area who are interested in cell cycle and DNA replication in prokaryotes and eukaryotes. The meetings are listed in the NIH Calendar of Events. Regular meetings include annual symposia with keynote addresses by leaders from the cell cycle field, followed by presentations by individuals in the group describing recent results in their labs. Special meetings are arranged for guest researchers who present an hour long seminar.
Centers for AIDS Research (CFAR) Steering Committee
This committee meets monthly to discuss the management of the CFAR program. The goal of the committee is to ensure that the CFARs fulfill their mission of facilitating HIV research through synergistic collaborations, mentoring of young and new investigators, and multidisciplinary projects involving basic, clinical, behavioral, and translational research. New members from the National Institute of Nursing Research (NINR) and the National Institute of Mental Health (NIMH) were added in 2012.
Child Abuse and Neglect Working Group
This working group focuses on building translational research on child abuse and neglect. The program staff members of this group also serve as the research subcommittee for Administration for Children and Families' Office on Child Abuse and Neglect Federal Interagency Workgroup on Child Abuse and Neglect. Through funding provided by an NIH R13 grant mechanism, the Translational Research on Child Neglect Consortium has held annual research and training meetings since 2007.
Chromatin and Chromosomes Interest Group
The aim of this Interest Group is to foster interaction among major laboratories in the areas of chromosome biology, and to enhance the education and development of junior investigators and fellows in NIH laboratories. With rapid advances and new technologies in the field, continuous interaction with members of the international community is critical to ensure the most effective development of these research programs.
Clinical and Translational Science Awards (CTSA) Strategic Goal IV Committee
The goal of the committee is to identify and develop effective partnerships between academic researchers and community stakeholders that allow for participation, discovery, application, and dissemination of science that improves public health, reduces health disparities, and promotes the translation of the results of clinical and translational research into practice and public policy. The community engagement workgroup sponsors several activities, supported by its several interest groups.
Clinical Trial Working Group Co-morbidity Project
The objectives of this working group were to discuss strategies for collecting co-morbidity data in clinical trials and for modifying eligibility criteria to safely increase enrollment into cancer clinical trials. Cardiovascular disease (hypertension) and diabetes were the diseases that were highlighted due to their prevalence in cancer patients and among racial and ethnic minorities in particular. The geriatric model and its risk assessment tools were presented. The outcomes of this project will include a white paper which will identify research priorities for cancer disparities in clinical and translational research in partnership with the American Society of Clinical Oncology and other cancer organizations.
Common Data Elements (CDEs) Working Group
The CDEs Working Group is charged by the Trans-NIH BioMedical Informatics Coordinating Committee to improve the communication and coordination of efforts to identify, develop, and promote the use of CDEs across NIH Institutes and Centers. As a first step, the working group will develop a web portal that will assemble information about NIH-supported CDE initiatives that are intended for use by NIH-funded researchers. In the longer term, the working group will take steps to encourage the use of CDEs by NIH-funded researchers, minimize overlap and redundancy in CDE initiatives, improve interoperability and compatibility between and among CDE initiatives and with other standards development activies (e.g., related to electronic health records) and assist NIH Institute and Center staff and researchers in identifying and using CDEs that are relevant to their projects.
Cytokine Interest Group
The NIH Cytokine Interest Group provides a forum for the interaction of scientists with a common interest in the immunology, molecular biology and physiology of cytokines. Major activities include a series of mini-symposia by NIH-area scientists dealing with multidisciplinary aspects of cytokine research, as well as seminars by outside speakers several times a year.
Diabetes Mellitus Interagency Coordinating Committee (DMICC)
The DMICC, authorized by Public Law 93-354, fosters collaborations between federal agencies that conduct or support diabetes-related activities and provides a forum for members to share information and ideas to synergize federal efforts to combat diabetes. DMICC meetings, held several times a year, help members identify emerging issues and opportunities and develop ways in which different government components can work together and build upon each expertise and resources. In addition to NIH Institutes and Centers, DMICC member organizations include non-NIH member representatives from the Agency for Healthcare Research and Quality, the Centers for Disease Control and Prevention, the Centers for Medicare and Medicaid Services, Health Resources and Services Administration, the Food and Drug Administration, the Department of Health and Human Services Office of Minority Health, the Indian Health Service, the Veterans Health Administration, the U.S. Department of Agriculture, and the Department of Defense.
NIH Participants: NIDDK, CSR, NCCAM, NCRR, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM
HHS OPDIVs Participants: FDA, AHRQ, CDC, HRSA
Emerging Infectious Diseases and the Human Animal Interface, Identifying Common Ground Among Federal Agencies
This 3 hour webinar was held to share information about the research portfolio, priorities and activities of U.S. Federal Agencies in the area of emerging zoonotic diseases and identify critical gaps/needs and potential areas of research for the biomedical community. Participating agencies included the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Environmental Health Sciences (NIEHS), the Centers for Disease Control and Prevention, the Food and Drug Administration, the U.S. Department of Agriculture, the Department of Homeland Security, the Department of Defense, and the U.S. Geological Survey. The goal of the meeting was to enable interagency communication, synergize efforts, identify individuals within federal agencies with shared interests in this field, and promote communication among them. One-hundred people participated in the webinar.
Extramural-Intramural Collaborations Workgroup
The Extramural-Intramural Collaborations Workgroup is a subcommittee of the NIH Clinical Center-Extramural Collaborations Committee. The goal of this workgroup is to develop recommendations for making the NIH Clinical Center available to extramural investigators in attempt to implement a recent recommendation of the Scientific Management Review Board to make the Clinical Center a true national resource. The specific plan developed by this group in its monthly meetings was presented to the NIH Advisory Board for Clinical Research.
Eyegene Common Data Elements and Vocabulary Standards
The goal of this collaboration is to review, enhance, and incorporate Eyegene 6,000 common data elements into The Logical Observation Identifier Names and Codes (LOINC®). LOINC® is supported by the National Library of Medicine (NLM) and is a federally required standard system for reporting clinical variables and survey instruments.
Federal Working Group on Bone Diseases
The Federal Working Group on Bone Diseases consists of representatives from federal agencies and voluntary organizations concerned with bone health. It offers a forum for sharing information and for facilitating the development of collaborative bone research activities based on the mission of each agency.
NIH Participants: NIAMS, CSR, NCATS , NCCAM, NCI, NEI, NIA, NIAAA, NICHD, NIDCR, NIDDK, NIEHS, NINR, ODP, ORWH
HHS OPDIVs Participants: FDA, AHRQ, CDC
Other Participants: CMS, DOD, VA, Dept. of Education, NASA
Federal Working Group on Dietary Supplements (FWGoDS)
The FWGoDS is a collection of individuals from NIH and other federal agencies that share information and discuss issues, initiatives, and research related to dietary supplements. The FWGoDS serves as means of communication between the NIH and its federal partners in order to co-fund research; expand opportunities for research-investigator training; and strengthen collaborative efforts involving dietary supplement research, education, and communication across the government.
NIH Participants: ODP, CC, CSR, FIC, NCCAM, NCI, NCRR, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, OBSSR
HHS OPDIVs Participants: FDA, AHRQ, CDC, HRSA
Other Participants: ODPHP, AOA, US Consumer Product Safety Commission, Federal Trade Commission, NASA, US Army Research Institute of Environmental Medicine, USDA, Uniformed Services University of Health Sciences
Health Literacy Work Group
This work group encourages empirical research through trans-NIH funding announcements on health literacy concepts, theory, and interventions as these relate to the Department of Health and Human Services’ public health priorities that are outlined in its HealthierUS and Healthy People 2020 initiatives. Health literacy is defined as the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions.
Healthy People 2020 – Sleep Health Working Group
This interagency working group provides oversight for the “Sleep Health” topic and objectives under Healthy People 2020. The Healthy People initiative is organized by the Department of Health and Human Services and provides a science-based framework for national objectives promoting health and preventing disease. The working group discusses topic content, evaluates progress toward achieving existing sleep health objectives, and identifies and prioritizes potential new sleep health objective opportunities.
Human Subjects Research Advisory Committee (HSRAC)
The primary responsibility of the HSRAC is to advise the NIH Deputy Director for Intramural Research on policies and procedures regarding the conduct of human subjects research in the NIH Intramural Research Programs. The HSRAC is comprised of the Deputy Director for Intramural Research, who is the chair, the Director of the Office for Human Subjects Research Protections, the 14 NIH Institutional Review Board Chairs, the Director of the Clinical Center, and the Chief of the Clinical Center Department of Bioethics.
ICARE: Interagency Collaborative to Advance Research in Epilepsy
ICARE is an interagency epilepsy working group that includes broad representation across the NIH Institutes and Centers involved in epilepsy-related research, as well as the Department of Defense, the Centers for Disease Control and Prevention, the Food and Drug Administration, and Veterans Affairs and multiple epilepsy research and patient advocacy groups with a primary focus on biomedical research. Annual meetings provide a forum for sharing information about ongoing and planned epilepsy research activities, highlighting advances, discussing needs and opportunities, and promoting increased collaboration toward common research goals.
Immunology Interest Group (IIG)
The IIG organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an Annual Immunology Retreat. IIG activities are organized by the Steering Committee, whose members are elected annually by the entire IIG community before the Immunology Retreat. IIG seminars are typically held every Wednesday.
In vitro Assessments for Antimicrobial Activity
The National Institute of Allergy and Infectious Diseases (NIAID) offers in vitro antiviral assays to screen compounds against many human viruses of public health and biodefense concerns. The National Institute of Neurological Disorders and Stroke (NINDS) and the National Center for Advancing Translational Sciences (NCATS) have provided compounds for screening.
Inclusion Tracking System Re-engineering Project (Business Process Modeling Phase)
The Inclusion Re-engineering Project was undertaken to update and modernize the Population Tracking module, which is the current system used by NIH staff to monitor the inclusion of women and minorities in clinical research and ensure compliance with the NIH Inclusion Policy. During the Business Process Modeling Phase, Subject Matter Experts from across NIH were brought together to develop a business process model of the inclusion process. The findings and recommendations of this group were reported in a white paper and served as a starting point for developing detailed requirements for the new Inclusion Monitoring System.
Inter-Institute Imaging Group (I3G)
The I3G meets monthly to facilitate discussion of scientific and programmatic issues in biomedical imaging. Topics range from anatomic imaging to functional and molecular imaging. Opportunities for collaborative efforts, ongoing programs and projects, and strategies for funding extramural imaging research are among the topics discussed at the meetings.
Interagency Breast Cancer and Environmental Research Coordinating Committee (IBCERCC)
The IBCERCC is a congressionally mandated body comprised of 18 voting members, including representatives of other federal agencies; non-federal scientists, physicians, and other health professionals from clinical, basic, and public health sciences; and advocates for individuals with breast cancer. The primary mission is to facilitate the efficient and effective exchange of information on breast cancer research activities among the member agencies, and to advise NIH and other federal agencies in the solicitation of proposals for collaborative, multidisciplinary research, including proposals to further evaluate environmental and genomic factors that may be related to the etiology of breast cancer. The Committee serves as a forum and assists in increasing public understanding of the member agencies' activities, programs, policies, and research, and in bringing important matters of interest forward for discussion. The IBCERCC is composed of three Subcommittees, all with efforts targeted at identifying gaps, reducing redundancy and enhancing collaboration among Federal agencies The State-of-the-Science Subcommittee aims to develop a comprehensive strategy and advise NIH in the solicitation of applications for collaborative, transdisciplinary research, and outline key research questions and methodologies. The Research Process Subcommittee aims to set research priorities, based on the work of the State-of-the-Science Subcommittee; reduce redundancies across Federal and non-governmental organizations; develop a process for soliciting research and fostering collaborations; highlight issues of peer review; and identify appropriate models for agencies to work together. The Research Translation, Dissemination, and Policy Implications Subcommittee aims to identify successful models and gaps in research translation and dissemination and recommend improvements, recommend policies to address translation and dissemination and precautionary public health policies supported by scientific evidence, identify methods to expand public participation in research translation and dissemination processes, and identify methods to more actively engage patient advocates and other stakeholders.
Interagency Modeling and Analysis Group (IMAG)
The IMAG is a working group of program officers across NIH and across ten government agencies, involved in managing research programs in biomedical, biological and behavioral systems that require the development of new and novel modeling and analysis methods. Since its creation in 2003, this group has convened monthly through virtual meetings and at various locations of the IMAG participants. The purpose of IMAG is to provide an open forum for communication among government representatives to share updates on individual programs from the various IMAG agencies, and to plan trans-Institute and Center and trans-agency activities that will have a broad impact on the communities served by IMAG. IMAG coordinates the Multiscale Modeling (MSM) Consortium. An MSM Consortium meeting was held at NIH in October 2012.
Intramural Glycobiology Scientific Interest Group Steering Committee
The Steering Committee is comprised of representatives from intramural and program staff from several NIH Institutes and Centers as well as the Food and Drug Administration(FDA) and the National Institute of Standards and Technology. The committee holds a monthly seminar series, an annual NIH/FDA Glycosciences Day Meeting (average of over 200 people in attendance), and, in 2010, held an NIH Research Festival Mini Symposium. In 2012, the committee also organized and taught a series of lectures entitled, “Special Topics Course in the Glycosciences,” to educate members of the NIH, FDA, and surrounding communities. This course will be offered again in 2013.
KICC is a subcommittee of the Kidney, Urology, and Hematology Interagency Coordinating Committee and consists of federal representatives involved in chronic kidney disease programs. KICC’s purpose is to encourage communication and collaboration to shape a more coordinated federal response to chronic kidney disease.
Knowledge Management and Health: Translational Applications for Semantic Abstraction Technologies
The purpose of this collaboration is to develop advanced information management applications to support the development of clinical practice guidelines. The underlying methodology is to extend and adapt Semantic MEDLINE, a biomedical information management system under development at the Lister Hill National Center for Biomedical Communications, National Library of Medicine.
Knowledge Management Tool-kit to Facilitate Research Portfolio Analysis
This project is a collaboration to develop tools to assist with portfolio analysis. The overarching goal is to create opportunities for users to interact with sophisticated information retrieval tools, supported by visualization software to steer the machine learning process as well as to refine the classification output. Success will conserve users’ time and maximize the efficient integration of users’ judgment and expertise. The focus is on the evaluation and optimization of currently available tools and resources.
Light Microscopy Interest Group
The Light Microscopy Special Interest Group holds monthly meetings, yearly social gatherings, and small vendor fairs. The group maintains a website and a listserv for researchers interested in light microscopy.
Lupus Federal Working Group (LFWG)
The LFWG provides a forum for mutual learning and sharing about lupus by enabling its members to learn about lupus research and related activities in intramural and extramural programs across NIH. NIH established the LFWG on behalf of the Secretary of the Department of Health and Human Services to facilitate collaboration among NIH components, other federal agencies, voluntary and professional organizations, and industry groups with an interest in lupus.
Managing Conflict of Interest in the Initial Peer Review of NIH Grants and Cooperative Agreements Committee
This committee established revised policy for managing conflict of interest in the NIH Peer Review process.
Martin Delaney Collaboratory Program Management Team
This team of Program Officials and Medical Officers was formed to help manage the Martin Delaney Collaboratory program, which is focused on basic and translational research toward finding a cure for HIV infection. The team communicates with members of the program through quarterly conference calls and annual face-to-face meetings. The goal of the team is to identify obstacles impeding progress in the field and to help develop solutions to help overcome these obstacles.
mHealth Research Inter-Institute Interest Group (IIG)
The purpose of the mHealth IIG is to: (1) foster better coordination of mHealth research activities across NIH; (2) interface with other IIG members with relevant interests; (3) invite speakers to give presentations on topics pertinent to mHealth research; (4) identify opportunities for collaboration across the NIH; and (5) partner with the Foundation for the NIH on the mHealth Summit, an annual meeting to advance collaboration in the use of wireless technology to improve health outcomes.
Muscular Dystrophy Coordinating Committee
This committee coordinates activities relevant to the various forms of muscular dystrophy across NIH and other federal agencies. The committee also includes members from patient organizations. Strategic planning efforts by the coordinating committee led to the development of an Action Plan for the Muscular Dystrophies (approved in December 2005), which contains specific research objectives appropriate to the missions of all committee member agencies and organizations, and thus serves as a central focus for research coordination.
Nanomedicine-Nanotech Interest Group
Nano-SIG is an NIH inter-institute Interest Group that brings together diverse, multidisciplinary researchers with common research interests in nanotechnology, nanoscience, and nanomedicine.
National Advisory Board on Medical Rehabilitation Research
The Director of NIH mandated establishment of the National Advisory Board on Medical Rehabilitation Research. The Board advises the directors of NIH, NICHD, and NCMRR on matters and policies relating to the Center's programs. The Board comprises of 12 members representing health and scientific disciplines related to medical rehabilitation and 6 members representing persons with disabilities.
National Cancer Institute (NCI) Alliance of Glycobiologists
The Alliance is a part of the National Cancer Institute's (NCI) Early Detection Research Network. The Alliance is working to reveal the cancer-related dynamics of complex carbohydrates, and to develop new, validated, clinical biomarkers for early cancer detection.
National Children's Study Program Chair Committee
The National Children''s Study Program Chair committee was a multi-agency workshop with participants from NIEHS, NCHS, and other extramural organizations. The mission of the committee was to reevaluate the sampling strategies for recruiting 100,000 pregnant women and their children for follow up. Multiple approaches were considered including clinic-based sampling and insurance-based providers sampling.
National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Prevention Guidelines Expert Panels and Work Groups
The panels and work groups are updating the NHLBI-sponsored clinical practice guidelines on hypertension, high blood cholesterol, and obesity, including guidelines for risk assessment and lifestyle as they relate to cardiovascular disease prevention. Systematic literature reviews are being conducted to provide the evidence upon which clinical recommendations will be made.
The goal of the Neurobiobank initiative is to provide human tissues to researchers to enable identification of pathology and genetics underlying brain disorders. A trans-NIH workgroup was formed in September 2010 to evaluate current approaches and investments in biobanking. In 2012, the NeuroBioBank IT Portal contract was issued to enhance coordination of brain banking activities and to simplify access to tissues. This web site will provide an inventory of tissues at all NIH-supported Brain and Tissue Repositories, as well as a way for investigators to request tissues and for brain bank directors to track and approve requests. Furthermore, the Neurobiobank Workgroup initiated a communications outreach process to increase public awareness of the importance of tissue donation for research on mental and neurological disorders.
This committee works in conjunction with NICHD''s responsibilities under the Best Pharmaceutical for Chlldren''s Act:
NICHD Responsibilities Under the BPCA
The NICHD has responsibility for approximately 25 percent of BPCA funding from its annual budget. The NICHD also organizes study design teams with the FDA and with other NIH Institutes. More than 20 NIH Institutes provide funding for these studies.
The NICHD has primary responsibility for administering, contracting, and monitoring studies to develop Investigational New Drug application data for potential label modification. The NICHD is also responsible for drafting label modifications for specific ages and indications for BPCA studies.
The NICHD leads BPCA efforts in part because of its strengths in conducting safe and effective clinical trials in populations thought to be fragile, such as children and pregnant women. The NICHD also has a record of success in the Pediatric Pharmacology Research Unit (PPRU) Network. The PPRU Network was a group of 13 sites and a data coordinating center that conducted pediatric clinical trials from 1994 to 2009. The BPCA Program has gained valuable knowledge and insight into the intricacies of pediatric pharmacology and the design of pediatric drug trials through the work of the PPRU. The PPRU is no longer in existence, but the NICHD Obstetric and Pediatric Pharmacology Branch is assembling a similar network of sites, called the Specialized Centers in Research and Pediatric Developmental Pharmacology Program (U54), to perform research in pediatric developmental pharmacology.
NIH Human Subjects Protection Liaison Committee
The committee was established by the Office of Extramural Programs to provide the Office of Extramural Research with input and recommendations on issues involving the protection of human subjects in NIH-sponsored research.
NIH Adherence Research Network
The specific aims of the NIH Adherence Research Network are to: (1) provide leadership, vision, and support to promote adherence research funded by NIH; and (2) evaluate and disseminate scientific information and funding opportunities for adherence research at NIH. The Network has collaborated on a wide variety of scientific activities, including issuing a request for information on future directions for NIH adherence research (NOT-OD-10-078), publishing a corresponding funding opportunity announcement (“Practical Interventions to Improve Medication Adherence in Primary Care,” PA-12-022 and PA-12-023), and conducting a meeting on “Advancing the Science of Adherence Assessment: A Working Meeting on Self-Report Measures” in October 2011.
NIH and National Aeronautics and Space Administration (NASA) Collaboration on Space-Related Health Research
In FY 2009, this working group produced a funding opportunity announcement to support biomedical experiments that astronauts could perform on the International Space Station. The International Space Station provides a special microgravity and radiological environment that Earth-based laboratories cannot replicate. The solicitation was a first step in a partnership to apply the International Space Station to research that complements NASA space exploration efforts. The first awards were made in September 2010 for three projects studying the biological effects of microgravity on different systems: osteocytes, the cells critical to bone integrity; immune cells, which have impaired responses to infections in both low gravity, and may mimic a similar condition in elderly people; and a model of the gastrointestinal tract, to understand the damaging effects of alcohol on protective mechanisms in the intestines. NIH funded a fourth award on the effects of gravity on bone cells in 2011.
NIH Autism Coordinating Committee (NIH/ACC)
In 1997, at the request of Congress, NIH formed the ACC to enhance the quality, pace, and coordination of efforts at NIH to find a cure for autism. Since then, the NIH/ACC has been instrumental in the research into, understanding of, and advances in autism (e.g., the creation of several research centers and networks to enhance the coordination and focus of autism researchers throughout the country).
NIH Biomedical Information Science and Technology Initiative Consortium
The mission of this consortium is to make optimal use of computer science and technology to address problems in biology and medicine by fostering new basic understandings, collaborations, and trans-disciplinary initiatives between the computational and biomedical sciences.
NIH Participants: NIGMS, CC, CIT, CSR, FIC, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIMH, NIMHD, NINDS, NINR, NLM, DPCPSI, ODP, OER, OIR, OM, ORS, OSP
NIH Blueprint for Neuroscience Research
The NIH Blueprint for Neuroscience Research is a cooperative effort that pools resources and expertise. The Blueprint supports the development of new tools, training opportunities, and other resources to assist neuroscientists in both basic and clinical research. The Blueprint enables daily collaboration in how NIH conducts neuroscience research and provides a framework for planning and implementing NIH’s neuroscience research efforts. The Blueprint does not target specific disorders. Instead, it creates common resources. Nervous system disorders appear in many forms including mental, neurological and developmental disorders, alcohol dependence, and drug addictions. Although there are clear differences, many disorders share characteristics of causation and outcome. Tools that are useful in one area – either in the laboratory or the clinic – are likely to be useful in others. One of these tools is the Blueprint Resource Antibodies Initiative for Neurodevelopment. This resource supports the creation and distribution of high-quality antibodies for use as markers in neurodevelopment research.
NIH Clinical Advisors to the Genetic Testing Registry
This group advises the National Library of Medicine (NLM) and the Office of the Director/Office of Biotechnology Activities on the development of the Genetic Testing Registry, an online resource that will provide a centralized location for test developers and manufacturers to voluntarily submit information about genetic tests, such as indications for use, validity data, and evidence of a test’s usefulness. The registry was introduced in February 2012.
NIH Cognitive and Emotional Health Project (CEHP) Steering Committee
CEHP is an ongoing trans-NIH initiative to assess the state of epidemiologic research on demographic, social, and biologic determinants of cognitive and emotional health in aging populations and the pathways by which cognitive and emotional health may reciprocally influence each other.
NIH Comparative Effectiveness Research (CER) Coordinating Committee
The NIH CER Coordinating Committee was created to provide advice to the NIH Director on the best use of CER stimulus funds, and communication and dissemination of CER findings. It is co-led by the National Institute on Aging (NIA) and the National Heart, Lung, and Blood Institute (NHLBI). CER is a rigorous evaluation of the impact of different options that are available for treating a given medical condition for a particular set of patients. Such a study may compare similar treatments, such as competing drugs, or it may analyze very different approaches, such as surgery and drug therapy.
NIH End-of-Life/Palliative Care Scientific Interest Group
This Interest Group provides a forum for interested researchers from the NIH Intramural and Extramural Research Programs as well as interdisciplinary scientists from the non-NIH community to discuss current trends and exchange information in end-of-life and palliative care research, including research translation. It serves as an important source for ideas and inter-institute discussions of ongoing activities in this area and provides a forum to foster career development, investigator training, and opportunities to collaborate in new initiatives.
NIH Financial Conflict of Interest (FCOI) Committee
The purpose of this committee is to develop FCOI regulations pertaining to grants, cooperative agreements, and contracts. A new, proposed FCOI regulation was published as a Notice of Proposed Rulemaking for public comment. The final step in the process is the posting of a Final Rule. A second charge to the committee is to assist Institute and Center extramural officials in evaluating complex FCOI issues, especially those involved with clinical trial networks. This standing committee meets on an as-needed basis. Panel members are expected to review and analyze file materials in advance of the meetings and participate in discussions for the purpose of providing guidance and advice on managing FCOIs.
NIH Genome-Wide Association Studies (GWAS) Senior Oversight Committee
The NIH GWAS Senior Oversight Committee serves as the principal trans-NIH committee charged with the oversight and management of policy development, implementation, and evaluation for genomic data sharing across NIH Institutes and Centers, advising the NIH Director regarding any policy development needs and on-going implementation practices. The Senior Oversight Committee is informed in its activities by the Technical Standards and Data Submission Steering Committee and the Participant Protection and Data Management Steering Committee.
NIH Genome-Wide Association Studies (GWAS) Technical Standards and Data Submission Steering Committee (TSDS)
The GWAS TSDS serves as the principal trans-NIH committee charged with promoting communication across the Institutes and Centers and initiating the development and on-going review of specific procedures related to issues of data submission, data security, database functionality and interoperability, quality control of genotype and phenotype data, and other scientific program topics that transcend individual Institutes and Centers with regard to the conduct of genomic data studies. The TSDS advises the Senior Oversight Committee of programmatic and policy needs and opportunities relating to genomic data sharing.
NIH Institute and Center International Representatives Forum
The Fogarty International Center (FIC) provides leadership and coordination for NIH international activities in several ways, including the NIH Institute and Center International Representatives Forum. Through bimonthly meetings and informal exchanges, this forum provides an opportunity for NIH staff to share ideas and information on relevant programs and to develop input from an international perspective on cross-cutting NIH initiatives. The Centers for Disease Control and Prevention, U.S. Agency for International Development, U.S. Department of State and other agencies interested in the international and global health research agenda have an open invitation to attend.
NIH International Tuberculosis (TB) Working Group
NIH TB research is coordinated through monthly meetings of the NIH International TB Working Group. NIH-funded domestic and international research includes studies to characterize drug resistance; the identification, preclinical development, and clinical evaluation of new drugs, diagnostics, and vaccines; and studies of the epidemiology and transmission of TB, including research addressing HIV/TB co-infection and TB in high-risk populations. Meetings often are attended by experts from other agencies as well, including USAID, the Food and Drug Administration, and the Centers for Disease Control and Prevention.
NIH Lesbian, Gay, Bisexual, Transgender, and Intersex (LGBTI) Research Coordinating Committee
The NIH LGBTI Research Coordinating Committee (LGBTI RCC) provides an important forum for discussing the diverse health issues for these communities and serves as a catalyst for developing additional research and research training initiatives for advancing research in these areas. Specific NIH LGBTI RCC responsibilities include: 1) Facilitating and coordinating collaborations and other activities related to LGBTI health research across the NIH Institutes, Centers, and Offices as well as with other federal agencies.2) Developing potential research and research training activities for NIH and Institute, Center, and Office leadership to consider as a result of recommendations from the Institute of Medicine report on LGBTI health. 3) Developing and recommending strategies to track and monitor NIH research initiatives and progress in this area. 4) Coordinating reporting on LGBTI research activities to the Department of Health and Human Services.
NIH Neuroprosthesis Group
The Neuroprosthesis Group is a working group of program officers across NIH with an interest in promoting neuroprosthesis and neuroengineering research. Activities include the discussion of planning trans-NIH initiatives, co-funding grants and contracts, and participating in joint site visits to mutually funded investigators.
NIH Obesity Research Task Force
Given the importance of the obesity epidemic as a public health problem, the NIH Obesity Research Task Force was established to accelerate progress in obesity research across NIH. The task force has been instrumental in fostering trans-NIH collaboration in obesity research, including basic, clinical, and population studies. The task force also sponsors an NIH seminar series on obesity research topics.
NIH Pain Consortium
The NIH Pain Consortium was established to enhance pain research and promote collaboration among researchers across the many NIH Institutes and Centers that have programs and activities addressing pain. These activities include research on sensory and basic mechanisms, as well as the emotional and biobehavioral aspects of pain. Age, sex, hormones, gender, ethnicity, and genetics all play a role in pain response and perception. The hope is that through increased knowledge of basic pain mechanisms, better pain management will result.
NIH Proteomics Interest Group (ProtIG)
The ProtIG is an NIH Special Interest Group that organizes seminars and workshops in relevant areas of proteomics, including talks on separation and protein identification methods, determination of post-translational modifications, protein-protein interactions, and bioinformatics and data management. A monthly seminar series is held to foster interaction among the Institutes and Centers and the research community.
NIH Rehabilitation Coordinating Committee
Pursuant to Public Law 101-613, the Director of NIH established a committee known as the Medical Rehabilitation Coordinating Committee. The Coordinating Committee makes recommendations to the Director of the Institute and the Director of the Center with respect to the content of the Research Plan and the activities of the Center that are carried out in conjunction with other agencies of the NIH and with other agencies of the Federal Government. The Coordinating Committee is composed of the Director of the Center, the Director of the Institute, and the Directors of the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Neurological Disorders and Stroke (NINDS), and such other national research institutes and representatives of other agencies of the Federal Government as the Director of NIH determines to be appropriate. The Coordinating Committee is chaired by the Director of the Center.
NIH Robotics Working Group
The Robotics Working Group engages program officers across NIH with an interest in promoting robotics and health robotics research. Discussions address topics related to planning trans-NIH initiatives, co-funding grants and contracts, and participating in joint site visits to mutually funded investigators. This working group is also linked to the efforts of the National Robotics Initiative.
NIH Scientific Interest Group
Trans-NIH scientific interest groups are assemblies of scientists with common research interests.
NIH Steering Committee on Trans Institute Angiogenesis Research Program (TARP)
The TARP Steering Committee works to encourage and facilitate the study of the underlying mechanisms controlling blood vessel growth and development, to identify specific targets and to develop therapeutics against pathologic angiogenesis in order to reduce the morbidity due to abnormal blood vessel proliferation in a variety of disease states, and to better understand the process of angiogenesis and vascularization to improve states of decreased vascularization.
NIH Stem Cell Task Force and Stem Cell Implementation Committee
The purpose of this task force is to enable and accelerate the pace of stem cell research by identifying rate-limiting resources and developing initiatives to overcome barriers to progress. In addition, the task force works closely with the intramural NIH Center for Regenerative Medicine, which was established in 2010. The Implementation Committee coordinates stem cell research initiatives and priorities of their NIH extramural programs with the task force.
NIH Working Group on Down Syndrome
This trans-NIH working group developed, with outside scientific and public input, the NIH Research Plan on Down Syndrome. The group is now charged with implementing that plan through the coordination of ongoing and new NIH-supported research efforts targeted to the areas of greatest scientific opportunity, especially the development of future treatments and the creation of the research resources (registry, database, biobank) necessary to move the field forward. In 2012, this working group worked on developing a Down Syndrome Registry, put out a Request for Information to the scientific community for feedback on NIH''s Down Syndrome Research Plan, and held a Down Syndrome Consortium meeting with Down Syndrome researchers and advocates.
NIH Working Group on Emergency Medicine
The Task Force on Research in the Emergency Setting has been re-constituted as the NIH Working Group on Emergency Medicine. This will be an ongoing group that will work with NIGMS Office of Emergency Care Research (OECR) to coordinate IC activities related to emergency medicine research and research training. The OECR Director will chair the working group.
In response to the 2006 Institute of Medicine report on the future of emergency care in the U.S. health system, NIH in 2007 assembled an internal task force to explore how best to enhance research in the emergency setting. Three round tables explored the opportunities and challenges for emergency research focusing on neurological and mental health, trauma, and medical/surgical emergencies. Pediatric and other vulnerable populations were incorporated within each round table. The task was for investigators in emergency research to identify current roadblocks, note solutions, and set priorities for research. The workshops also fostered a greater understanding of how investigators in emergency research might best access NIH resources through the competitive grant mechanism.
NIH's Strategic Communications Planning Project
The National Human Genome Research Institute’s (NHGRI) Communications and Public Liaison Branch leads one of the five working groups in the NIH''s strategic communications planning project. The NIH Associate Director for Communications and Public Liaison organized the effort to produce a new strategic communications plan for the NIH Director. Starting in the summer of 2011, the committee began to organize working groups to contribute to the plan. The Communications and Public Liaison Branch in the NHGRI Office of Policy, Communications and Education, co-chairs of the working group assigned to revitalize the websites of the 27 Institutes and Centers, along with NIH’s main website, NIH.gov. The initial strategy includes numerous components, but envisions a virtual overhaul of all of the Institute and Center principal websites and having them harmonized into cohesive corporate whole. The next steps will determine resources and timelines for project.
NIH- South Africa Medical Research Council (MRC) Program
The NIH-South Africa MRC initiative is a formal collaborative program that is being established through the development of a Memorandum of Understanding between NIH and the MRC, and a joint research program with joint investment, and a joint review process. Current activities include the planning of a scientific meeting in June 2014 in Durban, South Africa that will create opportunities for additional U.S. scientists to interact with South African scientists.
NIH/FDA Leadership Council’s Workgroup on Preclinical Toxicology
The NIH/Food and Drug Administration (FDA) Leadership Council has been established to help ensure that regulatory considerations form an integral part of biomedical research planning and that the latest science is integrated into the regulatory review process. The Preclinical Toxicology Workgroup is one of six smaller subcommittees of the larger Council.
NINDS Common Data Elements and Vocabulary Standards
This activity involves reviewing, enhancing, and incorporating the National Institute on Neurological Diseases and Stroke (NINDS) 7,700 common data elements into The Logical Observation Identifier Names and Codes (LOINC®), a National Library of Medicine-supported and federally required standard system for reporting clinical variables and survey instruments.
Nutrition Coordinating Committee (NCC)
Nutrition is a "major priority area" within the Department of Health and Human Services. As such, the NCC was established by the NIH in 1975 to improve inter-organization communication and research coordination of nutrition activities within NIH. The mandate of the NCC is to review, stimulate, and encourage the necessary support of nutrition research and training and to define the role of nutrition in health promotion and disease prevention and management. The NCC meets monthly to provide an open forum for members to report on current and future nutrition research, policy activities, and research funding and training opportunities. NCC meetings are chaired by the Director or Deputy Director of the the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Division of Nutrition Research Coordination (DNRC), and DNRC staff coordinate the meeting agendas and follow-up activities and announcements. Scientific seminars and discussions are featured during the NCC meetings as a means of disseminating information on timely nutrition research, diet and health guidance, nutrition and health policy, and program activities to NCC members.
NIH Participants: NIDDK, CC, CSR, FIC, NCCAM, NCI, NCRR, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NICHD, NIDA, NIDCD, NIDCR, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, OBSSR, ODP
HHS OPDIVs Participants: FDA, CDC, HRSA
Participant Protection and Data Management Steering Committee
This committee advises the Senior Oversight Committee of the programmatic and policy needs and opportunities related to implementation of NIH’s data sharing policy for genome-wide association studies. The committee has focused on developing common processes and forms for NIH’s Data Access Committees and provided a forum for discussing implementation issues.
Pediatric neuroimaging Workgroup
The NICHD Pediatric Workgroup collaborates with other NIH ICs to advance knowledge on pediatric neuroimaging from different clinical populations. This workgroup helps advance multifaceted research and training programs that promote basic and applied research to gain a deeper understanding of the linkages among genes, the developing brain, and behavior.
Pharmacogenetics Research Network
This is a program to study the pharmacogenetics of medicines used to treat various diseases.
PhenX Project – Genome-Wide Association Studies
PhenX is a three-year project to contribute to the integration of genetics and epidemiologic research. The project has prioritized 20 research domains related to complex diseases and environmental exposures. Consensus building is being used to develop a recommended minimal set of high priority measures for use in genome-wide association studies and other large-scale genomic research efforts. High priority measures will maximize benefits of future research by enabling cross-study comparisons and analysis. Selection and specification of the measures are driven by the scientific community via the PhenX Steering Committee, Working Groups, and PhenX Surveys.
Pigment Cell and Melanoma Research Interest Group
During the almost 16 year life of the Pigment Cell and Melanoma Research Interest group, it has become an open and organized forum for scientists and physicians with interests in investigating the different biological aspects that are involved in pigmentation, melanoma and allied fields. As of today, the group has over 90 members from NIH and from throughout the world. Every day, our goal is to have a clear path to the dynamic challenges in our field many of them considered global issues such as the effects of increased risk of ultraviolet radiation exposure.
Placebo Working Group
This working group was established to further develop research on the placebo response. An initiative soliciting research applications has been published, and a symposium was held in January 2012 entitled "Exploiting Placebo Responses in Clinical Practice: What Do We Need to Know?" The discussion focused on research opportunities and needs within five focus areas.
Post-traumatic Stress Disorder (PTSD)/Traumatic Brain Injury (TBI) Workgroup
A 2012 White House Executive Order, emphasizing support of service members, veterans, and their families as a “top priority,” called for an urgent increase in the Departments of Health and Human Services (HHS), Defense (DOD), and Veterans Affairs (VA) research commitments and collaborations to address the problems of PTSD, TBI, and suicide. Section 5 of this Executive Order requested a National Research Action Plan to develop biomarkers, define the pathophysiology, and create new treatments for PTSD. HHS has charged the National Institute of Mental Health (NIMH) to lead this effort along with a parallel effort for TBI led by the National Institute of Neurological Diseases and Stroke (NINDS), with both Institutes working closely with the VA and DOD. Fortunately, prior investments interrogating the molecular, genomic, and circuitry changes that give rise to PTSD in the context of environmental factors provide the requisite foundation to respond to this White House request for biomarkers for risk prediction, as well as new targets for medications and other therapies to treat PTSD. Such an investment has the potential to revolutionize the care for individuals at high risk for PTSD, and prevent the development of chronic complex treatment resistant PTSD.
Prevention Research Coordinating Committee (PRCC)
This committee serves as a venue for exchanging information related to recent scientific advances in disease prevention; examining the impact of new policies on research; planning new or discussing ongoing initiatives; and highlighting program accomplishments. As a trans-NIH, trans-agency committee, the PRCC provides a broad perspective on the current state-of-the-science and actively disseminates information about prevention-related activities sponsored by federal and non-federal organizations to the NIH Institutes and Centers.
NIH Participants: ODP, CC, FIC, NCCAM, NCI, NCRR, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIMH, NIMHD, NINDS, NINR, NLM, OBSSR, ORWH
HHS OPDIVs Participants: AHRQ, CDC
Other Participants: Office of the Secretary -- Office of Disease Prevention and Health Promotion
Quantitative Systems Pharmacology Working Group
This working group meets periodically and has organized two workshops on systems pharmacology as an emerging field. Systems pharmacology explicitly seeks to incorporate classical approaches from physiology, pharmacology, and cell biology and is not limited to "omics" and bioinformatics analysis. Success in quantitative and systems pharmacology approaches will make it possible to discover and design better drugs, predict patient-specific responses to therapy, and ultimately improve clinical outcomes.
Research Prioritization Task Force of National Action Alliance for Suicide Prevention (NAASP)
The NAASP was founded in September 2010 at the request of Department of Health and Human Services (HHS) Secretary Kathleen Sebelius and the Department of Defense Secretary Robert Gates. It is a public-private partnership designed to advance the National Strategy for Suicide Prevention in the United States. The NAASP’s Research Task Force—co-chaired by the Director of the National Institute of Mental Health (NIMH), and Phillip Satow of the National Council for Suicide Prevention and the Jed Foundation—is charged with developing a process to prioritize suicide prevention research efforts and consider ways to integrate science and service to ensure that suicide deaths decrease significantly within the next decade. NIMH provides the lead staff for this effort, which includes representation from the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), other HHS agencies (Centers for Disease Control and Prevention, Substance Abuse and Mental Health Services Administration, Indian Health Service, Surgeon General’s Office), and agencies outside HHS (e.g., Veterans Affairs, Department of Justice). The Office of Behavioral and Social Sciences Research (OBSSR) provided support for the initial meeting of the overview experts who are developing the research priorities. The Office of Disease Prevention (ODP) has provided support for a journal supplement to contain papers stemming from workgroup meetings.
NIH Participants: NIMH, NIAAA, NIDA, NIMH, OBSSR, ODP
HHS OPDIVs Participants: CDC
Other Participants: Year Activity Originated: September 2010 through April 2013; ongoing meetings (in person, conference calls)
Semantic Portfolio Analyst
The purpose of this collaboration is to to enhance the Semantic Portfolio Analyst application with semantic knowledge on biology research and technology. The underlying methodology is to adapt Semantic MEDLINE, a biomedical information management system under development at the Lister Hill National Center for Biomedical Communications, National Library of Medicine (NLM).
Smoking and Schizophrenia Working Group
The working group was established to plan a scientific workshop on the state of the science of smoking cessation interventions for people with schizophrenia. The workshop was held to inform NIH staff about scientific gaps and future directions for research in this area.
Special Populations Research Forum
This forum provides a trans-NIH platform for sharing and examining programs and initiatives designed to enhance and accelerate the development of research careers of individuals from underrepresented (racial/ethnic and health disparity) populations. The forum ultimately seeks to consider a broad range of activities pertinent to the conceptualization, implementation, review, administration, management, and evaluation of research, training, and outreach of programs based in institutions serving underrepresented populations.
Steering Committee for Standards of Research on Chronic Low Back Pain (cLBP)
The Steering Committee for Standards of Research on cLBP was formally established in July 2011 as a subcommittee of the NIH Pain Consortium. The Steering Committee will work to develop standard diagnostic definitions and outcome measures for use in clinical research studies on cLBP. They also will oversee a process to establish standards of research on cLBP that will facilitate better cross-comparison of related research studies.
Synchrotron Program Officers Group (SPOG)
The SPOG meets approximately twice per year to discuss and/or plan for the following: the needs of the biomedical research community for synchrotron radiation; the balance among the nation’s synchrotron radiation beamlines for the various structural biology techniques; the newest technologies; and cooperative (trans-NIH and interagency) funding.
Systems Biology Scientific Interest Group (SysBioSIG)
SysBioSIG sponsors activities exploring the diverse aspects of systems biology. This interest group hosts seminars and workshops to exchange ideas between scientists conducting research in systems biology.
TGF-beta Superfamily Interest Group
The Tumor Growth Factor (TGF)-beta superfamily occupies a central position in the signaling circuits that control cell growth, differentiation, and death. Seminal work has resulted in a deeper appreciation of the integration of TGF-beta pathways into signaling networks at large and its disruption in a wide variety of human disorders. Although, TGF-beta remains elusive in terms of a complete understanding of its multifunctional modes of action, its potential as a therapeutic target in many pathological settings is promising. The TGF-beta Superfamily Interest Group keeps abreast of advances in the field of TGF-beta superfamily research and in the global ramifications when TGF-beta signaling goes awry in diseases such as cancer, diabetes, obesity, immunological disorders, and pathological fibrosis. The group also serves as a platform for dissemination of TGF-beta-related reagents and expertise on campus.
The Blueprint Neurotherapeutics Network (BPN)
The NIH BPN was established by the NIH Blueprint for Neuroscience (a collaborative effort among 16 NIH Institutes, Centers, and Offices to support neuroscience research) to bridge the gap in drug development between academic and industry research and develop novel drugs to treat nervous system disorders. The network offers neuroscience researchers a "virtual pharma" to develop promising hit compounds, from chemical optimization through phase I clinical testing. Participants in the BPN receive funding to conduct bioactivity and efficacy testing as well as access to NIH-contracted drug development services and consultants who have had years of experience in drug discovery. The BPN mission spans the gamut of disorders of the nervous system, and initial disease targets include Alzheimer’s disease, Parkinson’s disease, stroke, major depression, narcolepsy, deafness, and vision loss.
The Breast Cancer & the Environment Research Program (BCERP)
The BCERP has been jointly funded by the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI) since 2003 and is presently in its second iteration. The BCERP supports transdisciplinary research on the interactions of environmental factors (including chemical, physical and social environmental) with genetic factors during windows of susceptibility throughout a woman’s life that potentially influences breast cancer risk. Each research project is required to partner with a local community-based or advocate organization focused on breast cancer as a concern. Community partners are involved in outreach activities that include, translating and communicating research finding to the public and policy makers as well as building and promoting partnerships among researchers, community members, and other engaged stakeholders. The community partners participate collaboratively with all the members of the BCERP Network, but especially with existing Community Outreach and Translation Cores associated with the ongoing epidemiologic investigations in supporting communication, outreach, and translation of research findings from the BCERP.
The NIH Bone Marrow Stromal Cell Transplantation Center (BMSCTC)
The objective of the BMSCTC is to facilitate the use of clinical grade ex vivo expanded BMSCs for treatment of patients with a variety of human diseases and disorders. The mission of the BMSCTCs is to provide investigators with high quality clinical grade BMSCs that are prepared using processes known to maintain their biological activities. In addition, they assist clinical investigators in the preparation of clinical protocols through the development of standard language for the cell manufacturing portion of the protocol, in the preparation of Food and Drug Administration (FDA) Investigational New Drugs for BMSC, and through the development of an FDA Master File.
Therapeutics Discovery Project (TDP) Team
TDP will explore new therapeutic uses for proprietary drug candidates (agents) across a broad range of human diseases. The program will match agents and associated data from eight pharmaceutical company partners with the best ideas for new therapeutic uses from the research from the biomedical research community. Although the National Center for Advancing Translational Sciences (NCATS) is the only NIH Institute named on the Funding Opportunity Announcements for this program, a Project Team has been put in place that is made up of 14 NIH Institute and Center contacts who serve as Science Officers/Project Scientists and Program Officials, and advise NCATS with regard to the proposed new therapeutic uses of the agents in disease-specific areas and continue to make program recommendations on the pre-clinical validation and clinical feasibility of proof-of-concept clinical trials.
Tobacco and Nicotine Research Interest Group (TANRIG)
TANRIG was formed in January 2003 with the goal of increasing collaboration, coordination, and communication of tobacco- and nicotine-related research among NIH Institutes and Centers, as well as with other relevant agencies within the Department of Health and Human Services.
The Tox21 initiative, championed by the National Center for Advancing Translational Sciences (NCATS), the National Institute of Environmental Health Sciences (NIEHS), the U.S. Environmental Protection Agency, and the Food and Drug Administration, was formed to develop high-throughput screening tests that measure cellular harm caused by environmental chemicals. The goals of the Tox21 initiative are to identify patterns of compound-induced biological response in order to characterize toxicity and disease pathways, facilitate cross-species extrapolation, and model low dose extrapolation, to prioritize compounds for more extensive toxicological evaluation, and finally, to develop predictive models for biological response in humans.
Trans-NIH Advisory Group (TAG), Therapeutics for Rare & Neglected Diseases (TRND) Program
The TRND Program solicits applications for collaborative preclinical therapeutic development support from a variety of external entities. Unlike other disease/organ system-centric Institutes and Centers, the TRND program within the National Center for Advancing Translational Sciences (NCATS) may receive proposals across the spectrum of disease areas. As such, the TAG is comprised of representatives from across a number of other Institutes and Centers to allow TRND Program Staff to receive disease/biology area-specific insight into the candidate applications under consideration.
Trans-NIH Bioethics Committee
This committee was established to contribute directly to NIH’s policy development and decision-making process by serving as a forum for discussion and analysis on a range of issues related to the conduct and oversight of NIH-funded clinical research.
Trans-NIH BioMedical Informatics Coordinating Committee
The trans-NIH BioMedical Informatics Coordinating Committee was established to improve communication and coordination of issues related to clinical and bio-informatics at NIH and with other relevant entities. The committee provides a forum for sharing inforamtion about NIH informatics programs and initiatives, including those related to IT standards development. The Committee also develops resources to coordinate and advance NIH-wide objectives related to biomedical informatics, including common data elements.
Trans-NIH Communication Group on Genetics and Common Disease
The Trans-NIH Communications Group on Genetics and Common Disease aims to develop and implement a cohesive communications plan to inform and educate both the public and health professionals about the genetics of common disease and traits. The group’s plan includes developing information regarding how to understand the implications of data generated by genome-wide association studies, how to interpret such data, and how to use it in personalized health care. Importantly, the plan also addresses the limitations of this sort of data and how to be an informed consumer and user of genomic information.
Trans-NIH Coordinating Committee for Lymphatic Research
This committee develops integrated NIH activities to enhance research in lymphatic biology and diseases. Members include both intramural and extramural NIH scientists.
Trans-NIH Coordinating Committee on HIV and Aging
This committee was established to promote intraagency collaboration in the conduct and funding of HIV and aging research, and related activities, as appropriate; to identify and develop approaches to address research opportunities and gaps; and to identify issues and activities that should be brought before NIH advisory groups.
Trans-NIH Coordinating Committee on Research on Women's Health (CCRWH)
The purpose of the CCRWH is to assist the Director of the Office of Research on Women''s Health in identifying the need for research on women’s health; making estimates each fiscal year of the funds needed to adequately support the research; identifying needs regarding the coordination of research activities, including intramural and extramural multidisciplinary activities; supporting the development of methodologies to determine the circumstances in which obtaining data specific to women (including data relating to the age of women and the membership of women in ethnic or racial groups) is an appropriate function of clinical trials of treatments and therapies; supporting the development and expansion of clinical trials of treatments and therapies for which obtaining such data has been determined to be an appropriate function; and encouraging the Institutes and Centers to conduct and support such research, including such clinical trials. The CCRWH serves as the major liaison with the NIH Institutes and Centers for communication and data exchange for trans-NIH attention to women’s health research including setting research priorities, strategic planning, and development of collaborative research protocols or funding; careers development programs; interdisciplinary collaborations; implementation of policies and programs to address the inclusion of women in clinical studies; and, implementation of sex differences research.
Trans-NIH Data Sharing Policy Working Group
This working group reviews matters associated with the current NIH Data Sharing policy, and develops tools and approaches for improving data sharing under NIH funding awards.
Trans-NIH Dissemination and Implementation Research Workgroup
The goal of the Trans-NIH Dissemination and Implementation Research Workgroup is to coordinate agency-level activities, such as webinars and working meetings, to advance the science of dissemination and implementation. Dissemination and implementation research focuses on advancing the knowledge base on how best to distribute health care information to patients, families, providers, administrators, and policymakers, and how to embed effective health interventions into various health service systems.
Trans-NIH Endocrine Group
The Trans-NIH Endocrine Group meets once every two months to discuss topics related to endocrine research. The topics include scientific discussions on endocrine research and review and program issues, as well as facilitating extramural research in this area.
Trans-NIH Fragile X Research Group
The charge of this group is to coordinate and monitor activities to implement high-priority research objectives described in the NIH Research Plan for Fragile X Syndrome and Associated Disorders. The group is composed of scientific experts across NIH. Group recommendations are designed for use by the NIH and research communities and to be shared with other federal agencies to facilitate coordinated research activities that will lead to timely detection, diagnosis, treatment, and prevention of the targeted disorders.
Trans-NIH Genetics/Genomics Coordinating Committee for HIV/AIDS Research
This committee was established to promote intraagency collaboration in the conduct and funding of HIV/AIDS genetics research, and related activities, as appropriate; to identify and develop approaches to address research opportunities and gaps; and to identify issues and activities that should be brought before NIH advisory groups.
Trans-NIH Global Health Research Working Group
The working group was established to explore, develop, and oversee specific actions NIH could take to support its Institutes’ and Centers’ global health research activities. The group meets quarterly and convenes advisory subgroups, as needed, to analyze issues and develop recommendations for individual Institutes and Centers or trans-NIH consideration.
Trans-NIH Hepatitis C Virus (HCV) Working Group
The charge of this group is to develop an integrated NIH-wide plan for research in HCV that addresses basic, translational, and clinical aspects of HCV infection aimed at the prevention and cure of the disease.
Trans-NIH Liver Cancer Working Group
The charge of this working group is to develop an integrated NIH-wide plan for research in liver cancer that addresses basic, behavioral, translational, and clinical aspects of liver cancer aiming at the prevention and cure of the disease.
Trans-NIH Minority Health and Health Disparities Strategic Plan
Two working groups, the Priority Setting group and the Development and Implementation working group, were created to set priorities and implement strategies.
Trans-NIH Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Research Working Group
Established in 1999, the working group includes representatives from NIH Institutes and Centers and the Office of the Director that support or serve as resources for biomedical research on ME/CFS. Working as a team with leadership from the Office of Research on Women's Health (ORWH), the working group identifies cross-cutting areas of research, and confronts challenges that embrace multiple Institutes and Centers. The group uses conferences, funding initiatives, an ORWH)-hosted website and educational outreach to advance research on ME/CFS. The ORWH Working Group chair serves as the ex officio representative to the Department of Health and Human Services Chronic Fatigue Syndrome Advisory Committee.
Trans-NIH Nanotechnology Task Force
The task force was established in April 2006 as a coordinating body for nanoscience and nanotechnology activities across NIH. This group also serves as the locus for interaction with nanotechnology activities in other federal agencies and for outreach to other stakeholders. The task force has representation from both intramural and extramural NIH staff.
Trans-NIH Neurofibromatosis Working Group
This group brings together NIH staff working in programs relevant to the biology and treatment of neurofibromatosis with patient advocacy groups and other federal agencies with programs in neurofibromatosis. The goal of the group is to share advances in understanding disease pathology and treatment strategies and to identify opportunities to support activities that will further advance the fight against this disease.
Trans-NIH Overlapping Chronic Pain Conditions Working Group
Formed in the fall of 2011, this working group brings together program directors from 12 Institutes and Centers involved in pain research as well as external members from pain advocacy groups. The group will assure coordination of research efforts across NIH on overlapping chronic pain conditions. In August 2012, the group helped organize a workshop on chronic overlapping pain conditions, which included scientific and patient advocate representation for vulvodynia, fibromyalgia, temporomandibular disorder, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), chronic pelvic pain, interstitial cystitis, and migraine. The goal of the workshop was to develop a coordinated research strategy addressing underlying etiology; the trajectory of disease; risk factors for onset, progression, and reversal; and approaches for developing outcome measures and diagnosis of these conditions. A set of research recommendations is being developed.
Trans-NIH Plan for HIV-Related Research Coordinating Committees
These committees are comprised of representatives from many of the NIH Institutes and Centers who assist in developing the annual Trans-NIH Plan for HIV-Related Research to ensure that the AIDS research budget funds the highest priority AIDS-related research. The plan 1) frames the development of the NIH AIDS research budget; 2) determines the use of NIH AIDS-designated dollars; 3) tracks and monitors AIDS research expenditures; and 4) informs the public, the scientific community, Congress, and the AIDS-affected communities about the NIH AIDS research agenda. The plan also shapes the NIH investment in biomedical and behavioral AIDS-related research and provides the framework to translate critical research findings into improved prevention and treatment strategies.
Trans-NIH Proteostasis Scientific Interest Group (SIG)
The Proteostasis SIG provides a forum to facilitate interaction, communication and collaboration among researchers working on different areas of the Proteostasis Network intramurally and outside NIH. The goal of the SIG is to develop and promote research initiatives on proteostasis and its relevance to human health and disease.
Trans-NIH Rare Diseases Working Group
The charge of this group is to develop an integrated NIH-wide plan for research in rare diseases that addresses basic, translational, and clinical aspects aimed at the prevention and cure of rare diseases.
Trans-NIH Sarcoidosis Working Group
This group was established to share and coordinate information on sarcoidosis research and to develop activities that might be jointly sponsored, including workshops and program announcements to highlight opportunities for research and collaborative projects. The group holds annual meetings that focus on exchange of information and discussion of future opportunities in sarcoidosis research.
Trans-NIH Sequencing Inventory Working Group
This group has surveyed the whole exome and whole genome sequencing projects supported by NIH Institutes and Centers and compiled them into an inventory of nearly 200 studies involving over 65,000 participants. The group is exploring approaches to joint analysis of the resulting sequencing data for purposes such as identifying rare loss of function variants and homozygous lethal variants in efforts to develop new diagnostic or therapeutic strategies.
Trans-NIH Sickle Cell Group
This group accelerates research on Sickle Cell disease across NIH by examining how new tools and techniques of genomics might be applied both to understand more fully the biology of sickle cell disease and to develop more effective therapeutic and preventive strategies for the disease.
Trans-NIH Sleep Research Coordinating Committee
The National Center on Sleep Disorders Research, of the National Heart, Lung, and Blood, Institute (NHLBI), leads a forum for program officers in participating Institutes and Centers for the discussion of sleep and circadian research and potential opportunities for programmatic coordination. The scope of discussion includes research, training, health information dissemination, and other activities with respect to sleep disorders, including biological and circadian rhythm research, basic understanding of sleep, chronobiology, and other sleep related research. The committee provides a point of contact and coordination for other federal agencies and grant applicants. Members also participate in annual meetings of the Sleep Disorders Research Advisory Board and the development of an NIH Sleep Research Plan.
Trans-NIH Social Media Collaborative
This working group connects staff responsible for managing the NIH Institute and Center social media outlets such as Facebook, Twitter, and YouTube. The collaborative coordinates its activities through monthly meetings where best practices, government regulations and collaborative strategies are presented and discussed. The membership represents nearly every Institute and Center at NIH, and routinely collaborate through an NIH Listserv, which is used to share postings that Institutes and Centers can use on their own outlets and through NIH Yammer. The National Human Genome Research Institute (NHGRI) Communications and Public Liaison Branch organized this activity on behalf of NIH Office of Communications and Public Liaison in 2012 and continues to provide leadership.
Trans-NIH Tuberous Sclerosis Complex (TSC) Working Group
This group brings together NIH staff working in programs relevant to the biology and treatment of TSC with patient advocacy groups (e.g., TS Alliance) and other federal agencies with programs in TSC. The goal of the group is to share advances in understanding disease pathology and treatment strategies and to identify opportunities to support activities that will further advance the fight against this devastating disease.
Trans-NIH Web Material Transfer Agreement Project
This project is focused on the development of an NIH-wide Web-based workflow management and database system to facilitate the rapid location of biological materials that can be shared from NIH laboratories and allow for near-instantaneous material transfer agreement turnaround time. Further, the system should provide novel metrics related to materials and investigators’ transfer patterns.
Trans-NIH Women’s Health Research Group
This research group is organized to support and encourage research in women’s health issues at the basic, translational, and clinical levels to include the biology and disease status of different organ systems. The group organizes a monthly symposium series and a mentoring program for fellows supported to perform research studies focusing on women’s health diseases.
Trans-NIH Working Group on Climate Change and Health
The working group was established to share, coordinate, and inform activities relevant to climate change and human health at the NIH. The group also serves as the locus for interaction with climate and health activities in other federal agencies and multilateral organizations. The group has been developing an NIH-wide research agenda for climate and health through workshops, lectures and internal analyses. A paper analyzing the relevant NIH portfolio has been provisionally accepted for publication in Environmental Health Perspectives. Out of these activities, a multi-IC Program Announcement on climate change and health research was issued titled Climate Change and Health: Assessing and Modeling Population Vulnerability to Climate Change (R21), currently in its third year.
Trans-NIH Xenopus Working Group
The mission of the Trans-NIH Xenopus Initiative, established in 1999, is to create critical community-wide resources for Xenopus models that aid in the understanding of embryonic development, organogenesis, oncogenesis, and cell biological processes. This initiative includes genomic and genetic resources, scientific meetings, and research program announcements.
Trans-NIH Zebrafish Coordinating Committee
The NIH established the Trans-NIH Zebrafish Coordinating Committee in the fall of 1997 in response to the scientific community’s recommendation to promote the use of zebrafish as a model organism for the study of vertebrate development and disease. This website was created to provide a central information resource, focusing on major NIH-organized zebrafish meetings; funding opportunities for zebrafish genomics and genetic resources; major resources generated from grants funded in response to Trans-NIH zebrafish initiatives; major zebrafish genomic and genetic resources; courses and scientific meetings related to the zebrafish initiatives; and, selected reports and publications. When appropriate, items not in response to the Trans-NIH zebrafish initiatives, but which are deemed relevant, will be posted. Posting decisions are made by a subcommittee of the Trans-NIH Zebrafish Coordinating Committee.
Translational Research Interest Group
The purpose of this group is to bring physicians and scientists from various disciplines together to discuss (1) efficient ways to accelerate the application of biomedical research discoveries to better help patients, and (2) the translation of clinical research observations into the development of improved preclinical disease models. This intramural scientific interest group coordinates seminars and workshops to help bridge the gap between laboratory research and clinical applications.
U.S.-China Program for Biomedical Collaborative Research Working Group
The purpose of the U.S.-China Program for Biomedical Collaborative Research is to stimulate collaborative basic, translational, and applied research between United States-based researchers and Chinese researchers in the areas of allergy, immunology, and infectious diseases including HIV/AIDS and its co-morbidities and co-infections, cancer, mental health, Parkinson’s disease, and stroke.
U.S.-India Joint Working Group on Prevention of Sexually Transmitted Diseases (STDs) and HIV/AIDS
This bilateral program between the United States and India was established in June 2006 with the signing of a Joint Statement on the Prevention of STDs and HIV. The program aims to facilitate successful United States and Indian research collaborations involving trans-NIH AIDS research efforts.
U.S.-Russia Collaboration on Research Related to HIV/AIDS
This bilateral program between the United States and Russia was established in March 2011 with the signing of a Memorandum of Understanding. The program was established to foster international collaborative research and research training on HIV/AIDS and the exchange of scientific information among researchers around the world. The program aims to facilitate successful United States and Russian research collaborations leading to subsequent advances in interventions and large-scale clinical trials research involving the following priority areas: research toward a cure, microbicides, vaccines, behavioral and social science research, molecular biology, tuberculosis coinfection, and other HIV-associated comorbidities such as cancer, and genomics.
Undiagnosed Diseases Program
The goals of this inter-institute program are to provide answers to patients with mysterious conditions that have long eluded diagnosis, and to advance medical knowledge about rare and common diseases.
United States Critical Illness and Injury Trials Group (USCIIT)
The USCIIT Group is funded by the National Institute of General Medical Sciences (NIGMS) to create a clinical research framework that reduces the barriers to investigation using the same investigator-initiated, evidence-driven, inclusive approach that has proven successful in other countries. The dual missions of the USCIIT Group are to foster investigator-initiated hypothesis testing and to plan strategically at the national level. The USCIIT Group does not fund clinical trials, but rather promotes the development of evidence-based clinical protocols and the subsequent preparation of applications for funding to test specific hypotheses. Investigators that span the gamut of critical illness and injury specialties are involved in this collaborative effort. It is expected that the USCIIT Group will act as a "network of networks", that is, it will not act in isolation, but will be part of a larger effort to bridge critical care trials groups world-wide. Its success will be based on collaborative leadership, non-hierarchical team culture, and open dialog among participants that will facilitate communication streams and help link new scientific knowledge with practice.
Vaccines for Cancer Prevention Working Group
This working group activity examines potential areas of overlap between the the National Cancer Institute (NCI) and the National Institute of Allergy and Infectious Diseases (NIAID). The goal is to identify vaccine studies of infectious agents that can be integrated to include preventative vaccine strategies for cancer. In FY2012, the NCI Division of Cancer Prevention established a working group to examine research opportunities in immunoprevention and develop future activities.
Wireless Medical Technologies Working Group
As follow-up to the Workshop on Personal Motion Technologies for Healthy Independent Living, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) created the Wireless Medical Technologies Working Group. The intent of this working group is to provide a forum for information sharing among federal agency representatives to better understand challenges and barriers to wireless medical technology adoption including issues of engineering development; regulatory issues governing safety, effectiveness, and communication; relevant standards; and reimbursement.
Wnt Working Group
Wnt genes and components of Wnt signaling pathways have been implicated in a wide spectrum of important biological phenomena, ranging from early organismal development to cell behaviors to several diseases, especially cancers. To help increase understanding of this important pathway, the Wnt Working Group was developed. Now a scientific interest group, the Wnt Working Group hopes to foster collaborations via broader interactions within the NIH intramural program. The Wnt Working Group currently consists of scientists from the NIH campus in Bethesda, the NCI facility at Frederick and the local extramural community. Participants come from labs entirely devoted to Wnt research as well as labs in which Wnt signaling is a narrower, perhaps transient interest. The group meets every few months to seek feedback on preliminary research results and encourage collaboration. Subject matter reflects the wide range of Wnt research in development and disease.
Working Group on Eukaryotic Pathogens and Disease Vectors Target Selection
This working group promotes and coordinates international, collaborative efforts to accelerate research and development of genetic resources in infectious diseases by identifying high priority eukaryotic pathogens and invertebrate vectors of diseases. The working group drafted white papers to support sequencing of identified high priority organisms.
Working Group on the NIH Project to Establish Biomedical Beamlines at NSLS-II
This working group was established to coordinate activities related to biomedical research at the new Department of Energy user facility for high energy x-rays at National Synchrotron Light Source-II (NSLS-II). The group is developing beamline specifications and instrumentation requirements for x-ray diffraction and x-ray scattering applications at NSLS‑II.